Rational design of polymeric micelles for targeted therapeutic delivery

Zheng, Yuting; Oz, Yavuz; Gu, Yimin; Ahamad, Nadim; Shariati, Kaavian; Chevalier, Jose; Kapur, Diya; Annabi, Nasim

doi:10.1016/j.nantod.2024.102147

Cited by 9 publications

(3 citation statements)

References 298 publications

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“…Various biodegradable polymers including amphiphilic peptides can serve as excellent polymers to form polymeric micelles for a single drug delivery, or in more advanced usages, as a multifunctional intelligent system [14,15]. Polymeric micelles can be designed in various strategies to improve efficacy and specificity for achieving targeted drug delivery and enhancing the therapeutic outcomes for patients [16], and have shown great promise in the targeted delivery of many anticancer agents [17][18][19]. Importantly, some pharmaceutical polymeric micelles have been proven and entered clinical evaluations [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Modification of Polyethylene Glycol-Hydroxypropyl Methacrylate Polymeric Micelles Loaded with Curcumin for Cellular Internalization and Cytotoxicity to Wilms Tumor 1-Expressing Myeloblastic Leukemia K562 Cells

Okonogi,

Chittasupho,

Sassa-deepaeng

et al. 2024

Polymers

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Curcumin loaded in micelles of block copolymers of ω-methoxypoly(ethylene glycol) and N-(2-hydroxypropyl) methacrylamide modified with aliphatic dilactate (CD) or aromatic benzoyl group (CN) were previously reported to inhibit human ovarian carcinoma (OVCAR-3), human colorectal adenocarcinoma (Caco-2), and human lymphoblastic leukemia (Molt-4) cells. Myeloblastic leukemia cells (K562) are prone to drug resistance and differ in both cancer genotype and phenotype from the three mentioned cancer cells. In the present study, CD and CN micelles were prepared and their effects on K562 and normal cells were explored. The obtained CD and CN showed a narrow size distribution with diameters of 63 ± 3 and 50 ± 1 nm, respectively. The curcumin entrapment efficiency of CD and CN was similarly high, above 80% (84 ± 8% and 91 ± 3%). Both CD and CN showed suppression on WT1-expressing K562 and high cell-cycle arrest at the G2/M phase. However, CD showed significantly higher cytotoxicity to K562, with faster cellular uptake and internalization than CN. In addition, CD showed better compatibility with normal red blood cells and peripheral blood mononuclear cells than CN. The promising CD will be further investigated in rodents and possibly in clinical studies for leukemia treatment.

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Section: Introductionmentioning

confidence: 99%

Modification of Polyethylene Glycol-Hydroxypropyl Methacrylate Polymeric Micelles Loaded with Curcumin for Cellular Internalization and Cytotoxicity to Wilms Tumor 1-Expressing Myeloblastic Leukemia K562 Cells

Okonogi,

Chittasupho,

Sassa-deepaeng

et al. 2024

Polymers

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“…In this case, the volume of the micellar core increases, and thus the encapsulation efficiency also increases. The encapsulation efficiency can also be improved by changing the nature of the hydrophobic block in order to optimize the compatibility with the loaded API [10].…”

Section: Introductionmentioning

confidence: 99%

Colloidal and Biological Characterization of Dual Drug-Loaded Smart Micellar Systems

Herman,

Rata,

Cadinoiu

et al. 2024

Polymers

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Smart polymeric micelles (PMs) are of great interest in drug delivery owing to their low critical micellar concentration and sizes. In the present study, two different pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) copolymer samples were used for the encapsulation of paclitaxel (PTX), ursolic acid (UA), and dual loading of PTX and UA. Based on the molecular features of copolymers, spherical PMs with sizes of around 35 nm and 140 nm were obtained by dialysis for P2VP55-b-PEO284 and P2VP274-b-PEO1406 samples, respectively. The micellar sizes increased after loading of both drugs. Moreover, drug encapsulation and loading efficiencies varied from 53 to 94% and from 3.2 to 18.7% as a function of the copolymer/drug ratio, molar mass of copolymer sample, and drug type. By FT-IR spectroscopy, it was possible to demonstrate the drug loading and the presence of some interactions between the polymer matrix and loaded drugs. In vitro viability was studied on 4T1 mammary carcinoma mouse cells as a function of time and concentration of drug-loaded PMs. UA-PMs and free PMs alone were not effective in inhibiting the tumor cell growth whereas a viability of 40% was determined for cells treated with both PTX- and PTX/UA-loaded PMs. A synergic effect was noticed for PTX/UA-loaded PMs.

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“…Thus, depending on composition and surface functionality, the drug carriers are capable of reaching the specific site of interest and delivering their cargo via the enhanced permeation and retention (EPR) effect or by active targeting [ 6 , 7 , 8 ]. Among the different types of polymer-based nanosystems, polymer micelles with a core-shell structure formed through self-association in the aqueous media of amphiphilic copolymers have demonstrated great potential as drug delivery systems [ 9 , 10 , 11 ]. Due to the fact that most of the drugs applied in cancer therapy are lipophilic, they can be accommodated into the micelles’ hydrophobic core for safe systemic circulation and delivery to the target tissue.…”

Section: Introductionmentioning

confidence: 99%

Poly(2-(dimethylamino)ethyl methacrylate)-Grafted Amphiphilic Block Copolymer Micelles Co-Loaded with Quercetin and DNA

Kalinova,

Videv,

Petrova

et al. 2024

Molecules

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The synergistic effect of drug and gene delivery is expected to significantly improve cancer therapy. However, it is still challenging to design suitable nanocarriers that are able to load simultaneously anticancer drugs and nucleic acids due to their different physico-chemical properties. In the present work, an amphiphilic block copolymer comprising a biocompatible poly(ethylene glycol) (PEG) block and a multi-alkyne-functional biodegradable polycarbonate (PC) block was modified with a number of poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) side chains applying the highly efficient azide–alkyne “click” chemistry reaction. The resulting cationic amphiphilic copolymer with block and graft architecture (MPEG-b-(PC-g-PDMAEMA)) self-associated in aqueous media into nanosized micelles which were loaded with the antioxidant, anti-inflammatory, and anticancer drug quercetin. The drug-loaded nanoparticles were further used to form micelleplexes in aqueous media through electrostatic interactions with DNA. The obtained nanoaggregates—empty and drug-loaded micelles as well as the micelleplexes intended for simultaneous DNA and drug codelivery—were physico-chemically characterized. Additionally, initial in vitro evaluations were performed, indicating the potential application of the novel polymer nanocarriers as drug delivery systems.

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Rational design of polymeric micelles for targeted therapeutic delivery

Cited by 9 publications

References 298 publications

Modification of Polyethylene Glycol-Hydroxypropyl Methacrylate Polymeric Micelles Loaded with Curcumin for Cellular Internalization and Cytotoxicity to Wilms Tumor 1-Expressing Myeloblastic Leukemia K562 Cells

Modification of Polyethylene Glycol-Hydroxypropyl Methacrylate Polymeric Micelles Loaded with Curcumin for Cellular Internalization and Cytotoxicity to Wilms Tumor 1-Expressing Myeloblastic Leukemia K562 Cells

Colloidal and Biological Characterization of Dual Drug-Loaded Smart Micellar Systems

Poly(2-(dimethylamino)ethyl methacrylate)-Grafted Amphiphilic Block Copolymer Micelles Co-Loaded with Quercetin and DNA

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