CD10, TDAG51, CK20, AR, INSM1, and Nestin Expression in the Differential Diagnosis of Trichoblastoma and Basal Cell Carcinoma

Leblebıcı, Cem; Sigirci, Buket Bambul; Talu, Canan Kelten; Koca, Sevim Baykal; Huq, Gülben Erdem

doi:10.1177/1066896918781719

Cited by 17 publications

(17 citation statements)

References 23 publications

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“…It has been shown before that Nestin is expressed in the hair follicle cells below the sebaceous glands and the outer-root sheath cells of the hair follicle in accordance with our results [25]. Nestin is further expressed in the tumour stroma of trichoblastomas but not BCCs [13]; other studies did not find Nestin a useful marker in the differentiation of these exact tumours as it was nonsignificantly differently expressed [26]. Nestin has been analysed together with CD133 in melanoma, SCCs, and BCCs, and when using Nestin, it was most suitable to differentiate the melanoma subtype [27].…”

Section: Discussionsupporting

confidence: 91%

Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours

Quist

Eckardt

Kriesche

et al. 2019

Stem Cells International

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Stem cells are multipotent cells that maintain the skin epidermis including skin appendages such as hair follicle, sebaceous glands, and sweat glands. There is evidence that reciprocal signalling between the epidermis and the dermis plays an important role in skin development, homeostasis, wound repair, and skin cancer. The origin of skin cancer that derive from skin appendages is still controversial, including basal cell carcinoma and even more of rare tumours such as sebaceous carcinomas and whether those tumours originate from resident tissue stem cells. To investigate whether markers reported to label dermal progenitor cells are preserved in the tumour including the tumour stroma of skin adnexal tumours, we tested 45 human basal cell carcinomas, including superficial, nodular, adenoid, infiltrating, and sclerosing types, and further 38 human tumours of skin appendages including 13 sebaceous adenomas and carcinomas, 20 eccrine sweat gland tumours, and 5 pilomatricomas, syringomas, and hair follicle tumours for the expression of the potential dermal and epidermal cell markers CRABP1, Nestin, and Ephrin B2 and compared these findings with healthy, age-related human epidermis. We detected that CRABP1, Nestin, and Ephrin B2 are expressed in the intratumoural stroma as well as the tumour invasive front of skin tumours of appendages and BCCs.

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Section: Discussionsupporting

confidence: 91%

Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours

Quist

Eckardt

Kriesche

et al. 2019

Stem Cells International

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“…In this regard, TB as a benign epithelial skin tumor displaying hair follicle differentiation [27] is mainly composed of germinative basaloid cells, but is also characterized by sparse intra-tumoral MC cells. The latter probably reflects a preserved potential of TB cells to act as epithelial progenitors and, therefore, to differentiate into MCs [28][29][30]. Applying massive parallel sequencing on a combined tumor consisting of MCC and TB components, we recently demonstrated that MCPyV integration in a TB cell gave rise to an MCPyV-positive MCC [31] indicating that an MCPyV-positive MCC can arise from an epithelial cell.…”

Section: Introductionmentioning

confidence: 90%

Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells

Kervarrec

Samimi

Hesbacher

et al. 2020

Cancers

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Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV). It is still under discussion, in which cells viral integration and MCC development occurs. Recently, we demonstrated that a virus-positive MCC derived from a trichoblastoma, an epithelial neoplasia bearing Merkel cell (MC) differentiation potential. Accordingly, we hypothesized that MC progenitors may represent an origin of MCPyV-positive MCC. To sustain this hypothesis, phenotypic comparison of trichoblastomas and physiologic human MC progenitors was conducted revealing GLI family zinc finger 1 (GLI1), Keratin 17 (KRT 17), and SRY-box transcription factor 9 (SOX9) expressions in both subsets. Furthermore, GLI1 expression in keratinocytes induced transcription of the MC marker SOX2 supporting a role of GLI1 in human MC differentiation. To assess a possible contribution of the MCPyV T antigens (TA) to the development of an MC-like phenotype, human keratinocytes were transduced with TA. While this led only to induction of KRT8, an early MC marker, combined GLI1 and TA expression gave rise to a more advanced MC phenotype with SOX2, KRT8, and KRT20 expression. Finally, we demonstrated MCPyV-large T antigens’ capacity to inhibit the degradation of the MC master regulator Atonal bHLH transcription factor 1 (ATOH1). In conclusion, our report suggests that MCPyV TA contribute to the acquisition of an MC-like phenotype in epithelial cells.

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“…It was postulated that the lack of cytokeratin 15 in BCC suggests a derivation from the bulge region of the hair follicle [ 46 ]. Furthermore, the expression of CD10 emphasizes the follicular derivation of these epithelial cells [ 47 , 48 ]. Several histopathological subtypes of BCC, with different prognostic values, have been described in the literature [ 45 , 49 ].…”

Section: Histopathological Features Of Bccmentioning

confidence: 99%

Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches

et al. 2020

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Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an aging population and widespread sun exposure. Although the mortality from BCC is negligible, this tumor can be associated with significant morbidity and cost. This review presents a literature overview of BCC from pathophysiology to novel therapeutic approaches. Several histopathological BCC subtypes with different prognostic values have been described. Dermoscopy and, more recently, reflectance confocal microscopy have largely improved BCC diagnosis. Although surgery is the first-line treatment for localized BCC, other nonsurgical local treatment options are available. BCC pathogenesis depends on the interaction between environmental and genetic characteristics of the patient. Specifically, an aberrant activation of Hedgehog signaling pathway is implicated in its pathogenesis. Notably, Hedgehog signaling inhibitors, such as vismodegib and sonidegib, are successfully used as targeted treatment for advanced or metastatic BCC. Furthermore, the implementation of prevention measures has demonstrated to be useful in the patient management.

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CD10, TDAG51, CK20, AR, INSM1, and Nestin Expression in the Differential Diagnosis of Trichoblastoma and Basal Cell Carcinoma

Cited by 17 publications

References 23 publications

Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours

Expression of Potential Dermal Progenitor Cell Markers in the Tumour and Stroma of Skin Adnexal Malignant and Benign Tumours

Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells

Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches

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