Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study

Jurjus, George J.; Nasrallah, Henry A.; Olson, Stephen C.; Schwarzkopf, Steven B.

doi:10.1017/s0033291700028403

Cited by 61 publications

(48 citation statements)

References 20 publications

(17 reference statements)

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“…To our knowledge, four studies (Jurjus et al, 1993;Kirkpatrick et al, 1997;Kwon et al, 1998;Nopoulos et al, 2000) have assessed relationships between CSP abnormalities and clinical symptoms, but only one study reported significant associations with more severe formal thought disorder (Kirkpatrick et al, 1997). Thus, the current study confirms an association between CSP and positive symptoms in patients with schizophrenia.…”

Section: Discussionsupporting

confidence: 74%

“…It is not clear, however, what the relationship of CSP findings is to clinical characteristics and abnormalities in limbic structures in patients with schizophrenia. Here, we note that of the four studies that assessed relationships between CSP and clinical symptoms (Jurjus et al, 1993;Kirkpatrick et al, 1997;Kwon et al, 1998;Nopoulos et al, 2000), only Kirkpatrick et al (1997) reported an association with more severe formal thought disorder. Additionally, associations with lower general intelligence (Nopoulos et al, 2000) and poorer prognosis (Fukuzako et al, 1996) have been reported.…”

Section: Introductionmentioning

confidence: 70%

“…Indeed, neurodevelopmental aspects of affective disorder have also been suggested in the literature (Bearden et al, 2001;Nasrallah, 1991). However, findings from previous MRI studies of CSP in affective disorder have been mixed (Jurjus et al, 1993;Shioiri et al, 1996) (reviewed and discussed in detail in Discussion), and these studies did not specifically evaluate psychotic patients with affective disorder except for our preliminary observation of 16 patients with psychotic affective disorder . Our previous findings of gray matter reduction of left posterior amygdala-hippocampal complex, common to first-episode psychotic patients with schizophrenia and affective disorder , together with a possible relationship between neurodevelopment of septum and the limbic structures, bear on the interesting question of whether or not both psychoses share neurodevelopmental abnormalities in midline structures and associated limbic systems.…”

Section: Introductionmentioning

confidence: 87%

“…Of further note, out of nine independent research studies investigating the prevalence and/or qualifying the rate of abnormal CSP in patients with schizophrenia compared with normal subjects using MRI (Degreef et al, 1992;DeLisi et al, 1993;Fukuzako et al, 1996;Hagino et al, 2001;Jurjus et al, 1993;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001;Shioiri et al, 1996), six reported positive findings (Degreef et al, 1992;DeLisi et al, 1993;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001;Shioiri et al, 1996). It is not clear, however, what the relationship of CSP findings is to clinical characteristics and abnormalities in limbic structures in patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

“…Incomplete fusion results in the persistence of a CSP, which reflects possible neurodevelopmental abnormalities of these midline and limbic structures (Rakic and Yakovlev, 1968;Sarwar, 1989;Shaw and Alvord, 1969). Particularly noteworthy, however, are recent high-spatialresolution MRI studies (Fukuzako et al, 1996;Hagino et al, 2001;Kwon et al, 1998;Nopoulos et al, 1997;Rajarethinam et al, 2001) that tend to report a higher prevalence of CSP (38.0-84.8%) in normal adults than previous MRI studies with lower spatial resolution (1.1-29.8%) (Degreef et al, 1992;DeLisi et al, 1993;Jurjus et al, 1993;Shioiri et al, 1996). These more recent in vivo MRI studies suggest that a small CSP is likely a normal variant.…”

Section: Introductionmentioning

confidence: 99%

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Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

Kasai

McCarley

Salisbury

et al. 2004

Schizophrenia Research

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A high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical symptoms, and with abnormalities in other limbic structures remains unclear, as does the question of whether a similar abnormality is present in affective psychosis. Seventy-four patients at their first hospitalization, 33 with schizophrenia and 41 with affective (mainly manic) psychosis, and 56 healthy control subjects underwent high-spatialresolution magnetic resonance imaging (MRI). CSP on six slices or more on 0.9375-mm resampled coronal images was categorized as abnormal. The prevalence of abnormal CSP in both schizophrenic patients (26.1%) and affective psychosis patients (18.2%) was significantly higher than was observed in control subjects (8.2%). In schizophrenic patients only, larger CSP was significantly associated with more severe thinking disturbance and smaller left parahippocampal gyrus gray matter volumes. While the relationships between CSP ratings and clinical symptoms did not significantly differ between the two psychosis groups as assessed by the comparison of regression slopes, the association with limbic volumes appeared to be specific to schizophrenic patients. These results suggest that psychosis associated with schizophrenia and affective disorder share, at least to some extent, neurodevelopmental abnormalities involving midline structures and associated psychopathological consequences. However, the association between abnormal CSP and limbic systems may be more specific to schizophrenia.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

Kasai

McCarley

Salisbury

et al. 2004

Schizophrenia Research

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Unreported anatomical variation of septum pellucidum

et al. 1997

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During gross anatomy dissections of the brain, a developmental abnormality of the septum pellucidum was found in a 31‐year‐old male cadaver. Other parts of the central nervous system in this cadaver were normal in every aspect. Histological samples were taken from the neighboring areas of this abnormality, and they were examined under light microscope and scanning electron microscope. In this abnormality of the septum pellucidum, the two laminae of the septum pellucidum were fused together and there was a hole located 1 cm anterior to its apex. The maximum diameter of the hole was 0.5 cm in the sagittal plane and 0.6 cm in the vertical plane. In the light microscopic and scanning electron microscopic examinations, the free margin of this foramen was regular, and the surrounding tissue was intact and histologically unique to the septum pellucidum. Ependymal cells were present at the free margin of the foramen. Cavum vergae, cavum septum pellucidum, and agenesis of the septum pellucidum are described in the literature. These three abnormalities are seen in cadavers usually with histories of schizophrenia and other psychiatric or neurologic disorders. In a retrospective study, the cadaver with this abnormality had a history of schizophrenia and no history or signs of any kind of brain or head operation. As far as we could ascertain, the abnormality described here has not been reported previously. Clin. Anat. 10:245–249, 1997. © 1997 Wiley‐Liss Inc.

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Linear parameters of normal and abnormal cava septi pellucidi: A post‐mortem study

Filipović

Teofilovski-Parapid

2004

Clinical Anatomy

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Anatomical variations in the dimensions of different brain structures have been correlated with clinical syndromes. This study on the parameters of normal and abnormal cavum septi pellucidi (CSP) can be of clinical significance. We obtained 479 brains from autopsied persons (310 males and 169 females, 377 normal or asymptomatic and 102 abnormal or symptomatic persons, aged 22-89 years) and observed that 110 brains (75 males and 35 females) had CSP. These cava were classified into two groups depending on the past medical histories of the autopsied person: 40 asymptomatic and 70 symptomatic cava. We have defined symptomatic cava as those in autopsied persons who had known past medical history of psychiatric or neurological disease. Asymptomatic cava were in autopsied persons who had no known past medical history of psychiatric or neurological disease. The CSP parameters (length, width, depth) of the symptomatic and asymptomatic groups were measured and were statistically analyzed. Analysis showed that the cava in the symptomatic group were significantly longer and wider. Discriminant function analysis was used to derive a mathematical formula to classify CSP into an asymptomatic or symptomatic group based on length and width measurements of the cavum.

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Cavum septum pellucidum in schizophrenia, affective disorder and healthy controls: a magnetic resonance imaging study

Cited by 61 publications

References 20 publications

Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study

Unreported anatomical variation of septum pellucidum

Linear parameters of normal and abnormal cava septi pellucidi: A post‐mortem study

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