Linear parameters of normal and abnormal cava septi pellucidi: A post‐mortem study

Abstract

Anatomical variations in the dimensions of different brain structures have been correlated with clinical syndromes. This study on the parameters of normal and abnormal cavum septi pellucidi (CSP) can be of clinical significance. We obtained 479 brains from autopsied persons (310 males and 169 females, 377 normal or asymptomatic and 102 abnormal or symptomatic persons, aged 22-89 years) and observed that 110 brains (75 males and 35 females) had CSP. These cava were classified into two groups depending on the past medical histories of the autopsied person: 40 asymptomatic and 70 symptomatic cava. We have defined symptomatic cava as those in autopsied persons who had known past medical history of psychiatric or neurological disease. Asymptomatic cava were in autopsied persons who had no known past medical history of psychiatric or neurological disease. The CSP parameters (length, width, depth) of the symptomatic and asymptomatic groups were measured and were statistically analyzed. Analysis showed that the cava in the symptomatic group were significantly longer and wider. Discriminant function analysis was used to derive a mathematical formula to classify CSP into an asymptomatic or symptomatic group based on length and width measurements of the cavum.

Prevalence of Septum Pellucidum Variations: A Retrospective Study

“…Although CT scans revealed that the prevalence of CSP ranged from 0.15% to 28% in adult patients, the studies using MRI scans reported higher rates that ranged from 5.1% to 58.7%. The prevalence of CSP in cadavers was found to be 22.96% in all cases, while the prevalence rate was 10.61% in the asymptomatic group [1]. In the present study, MRI scans revealed that the prevalence of CSP was found to be 3.7%, which is lower than the reported prevalence rates.…”

“…The overall prevalence rate was 22.96%. In addition, CSP dimensions were significantly longer and wider in the symptomatic group [1]. In the present study, the prevalence of CSP on MRI scans was 3.7%, a rate lower than that in the asymptomatic group.…”

“…This structure, which is usually 1 -3 mm thick, contains septal nuclei. The septum pellucidum is a component of the limbic system and has an important role in the connections between the hypothalamus and hippocampus, amygdala, habenula, and reticular formation of the brain stem [1] [2] [3].…”

“…The reason for this wide range was linked to the developments in imaging methods, more frequent use of imaging methods, and use of thinner slices in these imaging methods that allows detection of small-sized pathologies.The prevalence of CSP in the present study was found to be 3.7%. Many papers have considered that CSP could be related to the development of psychiatric disorders such as schizophrenia[1] [5][20].…”

Cavum Septum Pellucidum, da embriologia à clínica: uma revisão da literatura

“…A definição de um CSP alargado não é consensual na literatura, mas muitos trabalhos têm utilizado 6 mm como ponto de corte para tentar separar os CSPs variantes da normalidade daqueles que possam carregar algum significado patológico 5,6,18,21,22,24,25,26,27 . Além das dimensões lineares, a classificação subjetiva 28,29,30 em graus também parece ser útil na diferenciação entre CSP patológico e variante anatômica.…”