Cavitation-induced release of liposomal chemotherapy in orthotopic murine pancreatic cancer models: A feasibility study

Camus, Marine; Vienne, Ariane; Mestas, Jean‐Louis; Praticò, Carlos Alberto; Nicco, Carole; Chéreau, Christiane; Marie, J. van; Moussatov, Alexei; Renault, Gilles; Batteux, Frédéric; Lafon, Cyril; Prat, Frédéric

doi:10.1016/j.clinre.2019.02.015

Cited by 8 publications

(3 citation statements)

References 43 publications

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“…More anecdotally, spheroids have also been exploited to develop other acoustically mediated drug delivery strategies using US-induced inertial cavitation, low-intensity US (LIUS), laser-generated focused US (LGFU), and US-induced mild hyperthermia ( Table 4 ) [ 93 , 94 , 95 , 96 ]. US-induced inertial cavitation …”

Section: Resultsmentioning

confidence: 99%

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

et al. 2023

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Tumor spheroids as well as multicellular tumor spheroids (MCTSs) are promising 3D in vitro tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of drug delivery methods. These models partly reflect the tridimensional architecture of tumors, their heterogeneity and their microenvironment, which can alter the intratumoral biodistribution, pharmacokinetics, and pharmacodynamics of drugs. The present review first focuses on current spheroid formation methods and then on in vitro investigations exploiting spheroids and MCTS for designing and validating acoustically mediated drug therapies. We discuss the limitations of the current studies and future perspectives. Various spheroid formation methods enable the easy and reproducible generation of spheroids and MCTSs. The development and assessment of acoustically mediated drug therapies have been mainly demonstrated in spheroids made up of tumor cells only. Despite the promising results obtained with these spheroids, the successful evaluation of these therapies will need to be addressed in more relevant 3D vascular MCTS models using MCTS-on-chip platforms. These MTCSs will be generated from patient-derived cancer cells and nontumor cells, such as fibroblasts, adipocytes, and immune cells.

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Section: Resultsmentioning

confidence: 99%

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

et al. 2023

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“…In fact, in many of these studies, HIFU was used to analyse the feasibility and efficacy of a combination of focused US and gemcitabine or doxorubicin in a mouse model of pancreatic cancer. This combined treatment was shown to bea more effective therapeutic response compared to other treatments [43,[75][76][77].…”

Section: Focused Ultrasoundmentioning

confidence: 99%

Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review

Coppola,

Grasso,

Fontana

et al. 2023

JCM

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Pancreatic ductal adenocarcinoma (PDAC) is a cancer with one of the highest mortality rates in the world. Several studies have been conductedusing preclinical experiments in mice to find new therapeutic strategies. Experimental ultrasound, in expert hands, is a safe, multifaceted, and relatively not-expensive device that helps researchers in several ways. In this systematic review, we propose a summary of the applications of ultrasonography in a preclinical mouse model of PDAC. Eighty-eight studies met our inclusion criteria. The included studies could be divided into seven main topics: ultrasound in pancreatic cancer diagnosis and progression (n: 21); dynamic contrast-enhanced ultrasound (DCE-US) (n: 5); microbubble ultra-sound-mediated drug delivery; focused ultrasound (n: 23); sonodynamic therapy (SDT) (n: 7); harmonic motion elastography (HME) and shear wave elastography (SWE) (n: 6); ultrasound-guided procedures (n: 9). In six cases, the articles fit into two or more sections. In conclusion, ultrasound can be a really useful, eclectic, and ductile tool in different diagnostic areas, not only regarding diagnosis but also in therapy, pharmacological and interventional treatment, and follow-up. All these multiple possibilities of use certainly represent a good starting point for the effective and wide use of murine ultrasonography in the study and comprehensive evaluation of pancreatic cancer.

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“…A study by our group evaluated the efficacy of a combined treatment with inertial cavitation and liposomal DOX (L-DOX) on an orthotopic model of pancreatic cancer in mice and rats [ 79 ]. After a follow-up at 9 weeks, the group treated with combined US and L-DOX exhibited significantly lower tumor volumes than the sham group, the US group, and the L-DOX group, with a trend towards lower tumor volume compared to the group treated with gemcitabine, which was not statistically significant.…”

Section: Fus-mediated Targeted Deliverymentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma: Current and Emerging Therapeutic Uses of Focused Ultrasound

Lafond

Lambin

Drainville

et al. 2022

Cancers

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Pancreatic ductal adenocarcinoma (PDAC) diagnosis accompanies a somber prognosis for the patient, with dismal survival odds: 5% at 5 years. Despite extensive research, PDAC is expected to become the second leading cause of mortality by cancer by 2030. Ultrasound (US) has been used successfully in treating other types of cancer and evidence is flourishing that it could benefit PDAC patients. High-intensity focused US (HIFU) is currently used for pain management in palliative care. In addition, clinical work is being performed to use US to downstage borderline resectable tumors and increase the proportion of patients eligible for surgical ablation. Focused US (FUS) can also induce mechanical effects, which may elicit an anti-tumor response through disruption of the stroma and can be used for targeted drug delivery. More recently, sonodynamic therapy (akin to photodynamic therapy) and immunomodulation have brought new perspectives in treating PDAC. The aim of this review is to summarize the current state of those techniques and share our opinion on their future and challenges.

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Cavitation-induced release of liposomal chemotherapy in orthotopic murine pancreatic cancer models: A feasibility study

Cited by 8 publications

References 43 publications

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review

Pancreatic Ductal Adenocarcinoma: Current and Emerging Therapeutic Uses of Focused Ultrasound

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