Chair's Introduction-7:30 Invited Papers 7:355aAA1. Why we should design for optimum reverberation times in rooms for speech communication. J. S. Bradley ͑Inst. for Res. in Construction, Natl. Res. Council, Montreal Rd., Ottawa, Canada K1A 0R6͒Various texts list recommendations for optimum reverberation times as ideal goals in rooms for speech communication. However, some newer documents, such as ANSI S12.60, talk about maximum recommended reverberation times in rooms for speech communication. The source of the changed approach can be traced to interpretations of experimental results that do not consider the full implications for speech communication in real rooms, and also to the fact that reverberation time is not an ideal predictor of the quality of speech communication. In the extreme, minimizing reverberation times would lead to near anechoic rooms for speech and inadequate signal-to-noise ratios. The need for optimum reverberation times can be explained as a simple need to first achieve adequate signal-to-noise ratios. However, a more complete understanding is obtained by examining the benefits of early-arriving reflections of speech sounds on the intelligibility of the speech to listeners. Attempts to determine optimum reverberation times for normal hearing listeners, which are based on a balance between avoiding excessive reverberation and maintaining adequate signalto-noise ratios, lead to a range of acceptable values that can vary with the ambient noise level. This discussion will be supported with examples from room acoustics measurements in classrooms and meeting rooms. 7:555aAA2. The relation between speech transmission index, clarity, and reverberation time and listening difficulty in the impulse response database of AIJ. Hiroshi Sato ͑Natl. Inst. of Adv. Industrial Sci. and Technol. ͑AIST͒, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan͒, Yoshio Nishikawa ͑Konoike Co., Ltd., Tsukuba 305-0003, Japan͒, Hayato Sato, and Masayuki Morimoto ͑Kobe Univ., Nada, Kobe 657-8501, Japan͒The Speech Communication Research Working Group of AIJ ͑Architectural Institute of Japan͒ is collecting information on rooms including digitized impulse responses ͑IRs͒ to establish a database for evaluating and designing the speech transmission quality of rooms. This database consists of 966 measured IRs. This study presents the relationships between speech transmission index ͑STI͒, clarity ͑Cx͒ and reverberation time ͑T͒ as measures to consider for the design and evaluation of the speech transmission performance of rooms. The data show a wide range of STI and Cx values for a given T, and the minimum STI at each reverberation time can be obtained by diffused field theory. STI and Cx are seen to be better indicators than T for the design of rooms for speech and that T is not as good. Relationships between STI, Cx, and listening difficulty ratings from previous studies ͓Proc. of RADS ͑2004͒, Proc. of Forum Acusticum, pp. 1713-1718 ͑2005͔͒ found both STI and Cx can be used as predictors of listening difficulty ratings. Finally, ...

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Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for beneficial tissue bio-effects are actively under development. The mechanical oscillations of circulating microbubbles, the most widely investigated cavitation nuclei, which may also encapsulate or shield a therapeutic agent in the bloodstream, trigger and promote localized uptake. Oscillating microbubbles can create stresses either on nearby tissue or in surrounding fluid to enhance drug penetration and efficacy in the brain, spinal cord, vasculature, immune system, biofilm or tumors. This review summarizes recent investigations that have elucidated interactions of ultrasound and cavitation nuclei with cells, the treatment of tumors, immunotherapy, the bloodÀbrain and bloodÀspinal cord barriers, sonothrombolysis, cardiovascular drug delivery and sonobactericide. In particular, an overview of salient ultrasound features, drug delivery vehicles, therapeutic transport routes and pre-clinical and clinical studies is provided. Successful implementation of ultrasound and cavitation nuclei-mediated drug delivery has the potential to change the way drugs are administered systemically, resulting in more effective therapeutics and less-invasive treatments.

Small (encapsulated) gas bubbles in a contrast medium react to an external oscillating pressure field with volume pulsations. Depending on the magnitude of the ultrasound wave, the vibrations will be related either linearly or nonlinearly to the applied acoustic pressure. For low acoustic pressures, the instantaneous radius oscillates linearly in relation to the amplitude of the applied external pressure field. The oscillation of the bubble is governed by parameters such as resonance frequency, damping coefficients, and shell properties. For higher amplitudes of the external field, the pulsation of the bubbles becomes nonlinear. The spectrum of the scattered ultrasound wave also contains higher harmonics of the emitted frequency in addition to the fundamental frequency. The emitted frequency, bubble size, and nonlinear propagation effects have significant influence on the harmonic generation. For encapsulated bubbles exposed to even higher acoustic amplitudes, their scattering effectiveness increases dramatically and becomes transient. The scattered frequency spectrum broadens, containing higher harmonics. This consequence is due to rupture, disappearance, change of gas content, etc. Using these specific characteristics of the contrast bubbles will open new perspectives in imaging and analysis for medical diagnosis.

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Doxorubicin is a potent chemotherapeutic whose severe side effects limit its application. Drug-targeted delivery with noninvasive techniques is required to increase the drug concentration locally and to reduce systemic side effects. Microbubble-assisted ultrasound has become a promising strategy for noninvasive local drug delivery. The aim of this study is to evaluate the applicability and the effectiveness of administration of doxorubicin combined with microbubble-assisted ultrasound in human U-87MG glioblastoma and MDA-MB-231 breast cancer cells. In the present study, the doxorubicin delivery aided by microbubble-assisted ultrasound enhanced the death of breast cancer and glioblastoma cells, including the induction of apoptosis. Various microbubbles were evaluated including Vevo Micromarker, BR14, SonoVue and experimental polymer shelled microbubbles. The results showed that Vevo Micromarker microbubble-assisted ultrasound could induce an enhancement of doxorubicin in glioblastoma and breast cancer cell death. Polylactide-Shelled PEG and Vevo Micromarker microbubbles were the best microbubbles for efficient doxorubicin delivery in the U-87 MG and MDA-MB-231 cells, respectively. Moreover, the induction of apoptosis by doxorubicin and Vevo Micromarker microbubble-assisted ultrasound was examined and results showed a positive increment for acoustic pressures above 600 kPa. The conclusions drawn from in vitro study show the potential of this strategy for an in vivo application.