Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis

Abstract

Objective: To investigate the expressions of caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous gastric and chronic non-atrophic gastritis tissues, and evaluate the correlation of these expressions with the development of gastric cancer.Methods: The expressions of caveolin-1, E-cadherin and β-catenin were detected by biotin-streptavidinperoxidase (SP) immunohistochemistry on 58 gastric cancer tissues, 40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues. The correlation between the expressions of caveolin-1, E-cadherin and β-catenin, and the clinicopathologic parameters of gastric cancer was analyzed retrospectively.Results: The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01). An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01). Moreover, low expressions of caveolin-1, E-cadherin and β-catenin correlated with tumor size, depth of invasion, lymph node metastasis and TNM stage (P<0.05). The positive rates of caveolin-1 and E-cadherin expressions decreased (P<0.01), while an abnormal rate of β-catenin expression increased inversely, with the degree of atypical hyperplasia (P<0.01). Caveolin-1 expression correlated positively with E-cadherin (r=0.41, P<0.05). Caveolin-1 (r=−0.36, P<0.05) and E-cadherin (r=−0.45, P<0.05) expressions negatively correlated with abnormal β-catenin expression.Conclusion: These results suggested that dysregulated expressions of caveolin-1, E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.

Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis

“…Though Cav-1 over-expression was documented to associate with Lymph node metastasis and TNM stage (Sun et al, 2012;Nam et al, 2013), here our results suggested that Cav-1 positive expression was not correlated with these clinicopathological features.…”

“…Indeed, even if it may play a role of tumor suppressor by inhibiting the signalling transduction products of some proto-oncogenes (Razani et al, 2001), its tyrosine-14 phosphorylation leads to growth stimulation (Lee et al, 2000), demonstrating that Cav-1 may also make an effect as a pro-tumorigenic factor. In the prognosis of gastric cancer, it has been reported that Cav-1 expression may serve as a promising molecular biomarker recently (Gao et al, 2005;Barresi et al, 2008;He et al, 2012;Sun et al, 2012;Nam et al, 2013;Zhao et al, 2013). However, these results were controversial.…”

“…1 record was eliminated data of the repeated data from the same population. Thus, a total of 6 papers met the inclusion criteria for the present meta-analysis (Gao et al, 2005;Barresi et al, 2008;He et al, 2012;Sun et al, 2012;Nam et al, 2013;Zhao et al, 2013) (Figure 1). We …”

Caveolin-1 Expression Level in Cancer Associated Fibroblasts Predicts Outcome in Gastric Cancer

“…The way we constructed the TMAs and the microarray system instrument were the same with our previous study [24], [25]. As previously studies did not report intratumoral heterogeneity of Cav-1 expression in GC and our feasibility experiment indicated that one core per tumor on TMA and large sections showed a good consistency [26], [27], [28], therefore, in testing experiment, one core was sampled in each case. Briefly, one core with a diameter of 1.5 mm was taken from each sample and inserted into empty “recipient” paraffin blocks; these blocks were cut into sections (4 µm thick) and used for QDs-IHC analysis.…”

Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy

“…In a study by Sun et al [26], Cav-1 expression was evaluated in 5 gastric cancer tissues, 40 precancerous gastric tissues (19 intestinal metaplasia and 21 dysplasia), and 42 nonatrophic gastritis tissues. They showed that Cav-1 positivity was significantly lower in the gastric cancer tissues compared to precancerous gastric and non-atrophic gastritis tissues [26]. Moreover, different from our study, low Cav-1 expression was found to be significantly correlated with lymph node metastasis and advanced pTNM stage.…”