Caveolin-1 Expression Level in Cancer Associated Fibroblasts Predicts Outcome in Gastric Cancer

Abstract

AimsAltered expression of epithelial or stromal caveolin-1 (Cav-1) is observed in various types of human cancers. However, the clinical significance of Cav-1 expression in gastric cancer (GC) remains largely unknown. The present study aims to explore the clinicopathological significance and prognostic value of both tumor cells and cancer associated fibroblasts (CAFs) Cav-1 in GC.Methods and ResultsQuantum dots immunofluorescence histochemistry was performed to examine the expression of Cav-1 in 20 cases of gastritis without intestinal metaplasia (IM), 20 cases of gastritis with IM and 286 cases of GC. Positive rates of epithelial Cav-1 in gastritis without IM, gastritis with IM and GC showed a decreasing trend (P = 0.012). Low expression of Cav-1 in CAFs but not in tumor cells was an independent predictor of poor prognosis in GC patients (P = 0.034 and 0.005 respectively in disease free survival and overall survival). Cav-1 level in tumor cells and CAFs showed no significant correlation with classic clinicopathological features.ConclusionsLoss of epithelial Cav-1 may promote malignant progression and low CAFs Cav-1 level herald worse outcome of GC patient, suggesting CAFs Cav-1 may be a candidate therapeutic target and a useful prognostic marker of GC.

Prognostic value of metastatic tumoral caveolin-1 expression in patients with resected gastric cancer.

“…In this study, regarding stromal Cav-1 expression, it was more frequently downregulated in diffuse-type (58.2%) than mixed or intestinal-type (41.8%) of Lauren classification (P = 0 045), which is consistent with the previous reports [29,30], and stromal Cav-1 protein did not show the prognostic role in curatively resected GC. The downregulation of Cav-1 is a major characteristic of CAFs, and existing studies have indicated that CAFs have the ability to inhibit cancer cell apoptosis, increase the growth of cancer cells, and activate tumor angiogenesis [16,18].…”

“…Thus, the loss of stromal Cav-1 has been reported to be a poor prognostic factor in various human cancers [31]. In previous study, low expression of Cav-1 in CAF was related with unfavorable prognosis in GC [30]. Compared to the present study including only primary R0 resection, the patient cohort in that study was heterogeneous, in which patients who received cytoreductive surgery and postoperative radiotherapy were included.…”

Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis

“…1 record was eliminated data of the repeated data from the same population. Thus, a total of 6 papers met the inclusion criteria for the present meta-analysis (Gao et al, 2005;Barresi et al, 2008;He et al, 2012;Sun et al, 2012;Nam et al, 2013;Zhao et al, 2013) (Figure 1). We …”

Advances in the application of nanotechnology in the diagnosis and treatment of gastrointestinal tumors

“…This technique was applied to assess the expression of Cav-1 and LC3B, which have been found to be independent predictors of gastric cancer prognosis in humans (43,44). QDs-based multiplexed biomarker detection has attracted significant attention as a reliable predictor of disease progression and treatment response (45).…”