Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy

Şeker, Mesut; Aydın, Dinçer; Bılıcı, Ahmet; Yavuzer, Dilek; Ozgun, Melin G; Özçelik, Melike; Aydin, Özhan; Aliustaoğlu, Mehmet

doi:10.1159/000456620

Cited by 17 publications

(18 citation statements)

References 30 publications

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“…On the other hand, the CAV1 gene can promote cancer by inhibiting apoptosis and promoting tumour metastasis and drug resistance 22,23 . Previous studies have shown that high expression of CAV1 is positively correlated with disease progression and poor prognosis of GC patients 24,25 , which is consistent with our ndings (HR value of CAV1 < 1). Some studies have explored the possible mechanism by which CAV1 affects the prognosis of GC patients.…”

Section: Discussionsupporting

confidence: 93%

Development and Validation of an Apoptosis-Related Genes Signature in Patients with Gastric Cancer

Yang

Shang

et al. 2021

Preprint

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Background: Gastric cancer (GC) is a common malignant tumour of the digestive tract. the prognosis of GC patients is still not optimistic. Apoptosis-related genes (ARGs) plays an important role in the development, invasion, metastasis and drug resistance of GC. Therefore, assessing the interaction between ARGs and the prognosis of GC patients may help identify specific biomarkers.Methods: Differentially expressed genes (DEGs) were identified by integrating gene expression profiling analyses from The Cancer Genome Atlas (TCGA) GC cohort and Gene Set Enrichment Analysis (GSEA) Database. Then, a risk score model was built based on Kaplan-Meier (K-M), least absolute shrinkage and selector operation (LASSO), and multivariate Cox regression analyses. Another cohort (GSE84426) was used for external validation. By combining risk scores with clinical variables, a nomogram was constructed to predict the prognosis of GC patients. Results: We screened 39 DEGS and established a three-gene signature(CAV1、F2、LUM) based on 161 ARGs. In addition, three-gene signature was identified as an independent factor in predicting the prognosis of GC patients and validated in an external independent cohort. Finally, we developed a nomogram that can be applied to clinical practice.Conclusions: Our study established a three-gene signature of GC based on ARGs that has reference significance for in-depth research on the apoptosis mechanism of GC and the exploration of new clinical treatment strategies.

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Section: Discussionsupporting

confidence: 93%

Development and Validation of an Apoptosis-Related Genes Signature in Patients with Gastric Cancer

Yang

Shang

et al. 2021

Preprint

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“…High Cav 1 expression is also associated with RAF-ERK signaling, cell cycle progression and colony forming ability ( 54 ). Patients with Cav 1-positive tumors, post-gastrectomy, display decreased disease-free and overall survival ( 55 ). Moreover, Cav 1 expression is associated with poor prognosis in GC ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

Rictor Activates Cav 1 Through the Akt Signaling Pathway to Inhibit the Apoptosis of Gastric Cancer Cells

Cao

Liu

et al. 2021

Front. Oncol.

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BackgroundRapamycin-insensitive companion of mammalian target of rapamycin (Rictor) protein is a core subunit of mammalian target of rapamycin complex 2, and is associated with cancer progression. However, the biological function of Rictor in cancer, particularly its clinical relevance in gastric cancer (GC) remains largely unknown.MethodsRictor expression and its association with clinicopathologic characteristics in GC were analyzed by immunohistochemistry. Effect of Rictor and Caveolin-1 (Cav 1) on GC cells apoptosis was evaluated via overexpression experiment in vitro. Mechanisms of Rictor and Cav 1 in GC were explored through overexpression and knockdown, by immunofluorescence and western blot analyses.ResultsRictor was upregulated in GC, and mainly located in the cytoplasm of cancer cells. Moreover, higher Rictor levels were associated with worse prognosis. Rictor could inhibit GC cell apoptosis and promote cell growth in vitro. The results of immunofluorescence revealed that Cav 1 localized in GC cell membrane but did not co-localize with Rictor. Further, Rictor regulated apoptosis-related proteins, long non-coding RNAs and also activated cellular signaling, thereby positively regulating Cav 1 expression. This effect was attenuated by the Akt inhibitor ly294002. Cav 1 did not significantly affect the ability of Rictor to inhibit tumor cell apoptosis.ConclusionsRictor is upregulated in GC and associated with worse prognosis. It inhibits tumor apoptosis and activates Cav 1 through the Akt signaling pathway to inhibit the apoptosis of GC cells. Rictor is, therefore, a promising prognostic biomarker and possible therapeutic target in GC patients.

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“…In Conversely, high stromal caveolin-1 in early prostate cancer was found to correlate with decreased malignancy, longer survival and favorable prognosis when managed by watchful waiting (134). In gastric cancers post-tumor resection, high caveolin-1 expression correlated with tumor relapse and lymph node metastasis (135,136). However, in colorectal cancer-derived liver metastasis post-hepatectomy, weak stromal caveolin-1 expression was a predictor of poor prognosis (137).…”

Section: Flotillinsmentioning

confidence: 99%

Rafting Down the Metastatic Cascade: The Role of Lipid Rafts in Cancer Metastasis, Cell Death, and Clinical Outcomes

et al. 2021

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Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the plasma membrane that play important roles in many pathophysiological processes. Rafts have been strongly implicated as master regulators of signal transduction in cancer, where raft compartmentalization can promote transmembrane receptor oligomerization, shield proteins from enzymatic degradation, and act as scaffolds to enhance intracellular signaling cascades. Cancer cells have been found to exploit these mechanisms to initiate oncogenic signaling and promote tumor progression. This review highlights the roles of lipid rafts within the metastatic cascade, specifically within tumor angiogenesis, cell adhesion, migration, EMT, and transendothelial migration. Additionally, the interplay between lipid rafts and different modes of cancer cell death, including necrosis, apoptosis, and anoikis will be described. The clinical role of lipid raft-specific proteins caveolin and flotillin in assessing patient prognosis and evaluating metastatic potential of various cancers will be presented. Collectively, elucidation of the complex roles of lipid rafts and raft components within the metastatic cascade may be instrumental for therapeutic discovery to curb pro-metastatic processes. Research.

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Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy

Cited by 17 publications

References 30 publications

Development and Validation of an Apoptosis-Related Genes Signature in Patients with Gastric Cancer

Development and Validation of an Apoptosis-Related Genes Signature in Patients with Gastric Cancer

Rictor Activates Cav 1 Through the Akt Signaling Pathway to Inhibit the Apoptosis of Gastric Cancer Cells

Rafting Down the Metastatic Cascade: The Role of Lipid Rafts in Cancer Metastasis, Cell Death, and Clinical Outcomes

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