Causes of repeated remodeling of left ventricle after Dor procedure

Shipulin, V. M.; Казаков, В. А.; Suhodolo, Irina V.; Кривощеков, Е. В.; Лежнев, А. А.; Kozlov, B. N.; Vaizov, Valery Ch.; Миллер, А. А.

doi:10.1510/icvts.2007.159426

Cited by 3 publications

(5 citation statements)

References 15 publications

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“…However, late after SVR, LV remodeling recured as the level of the rats without SVR. These findings do not conflict with the clinical reports of SVR [12,13].…”

Section: Attenuation Of Recurrence Of LV Remodeling After Svrsupporting

confidence: 73%

“…In other studies, one of the concerns has been reported to be recurrence of LV remodeling after SVR [12,13]. These studies demonstrated that LV size increased again at 1 year after SVR.…”

Section: Introductionmentioning

confidence: 84%

“…Damaged mitochondria have been reported to accumulate due to pressure overload and leak reactive oxygen species and apoptogenic proteins [26]. It has also been reported that the accumulation of mitochondria was observed in patients with recurrence of LV remodeling after SVR, although the mechanism was unclear [13]. Taken together, the possible roles of autophagy in preventing LV remodeling after SVR in patients with ICM are to promote the degradation of damaged mitochondria and to improve mitochondrial function.…”

Section: Autophagy: a Mechanism Of Trehalose Effect?mentioning

confidence: 97%

“…These studies demonstrated that LV size increased again at 1 year after SVR. Furthermore, the hemodynamic values returned to the preoperative level in patients with recurrence of LV remodeling [12][13][14][15]. We speculate that the recurrence of LV remodeling is related to the nonbeneficial effects of SVR demonstrated in the STICH trial.…”

Section: Introductionmentioning

confidence: 99%

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Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

et al. 2022

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Recurrence of left ventricular (LV) remodeling after surgical ventricular reconstruction (SVR) for ischemic cardiomyopathy has been reported to be partially attributed to autophagy. We aimed to examine the effects of trehalose, an autophagy inducer, on the recurrence of LV remodeling after SVR. After SVR in rats with ICM, trehalose was orally administered. The changes in LV end-diastolic dimension (LVEDD) and fractional shortening (FS) were evaluated. The activation of myocardial autophagy was also estimated by autophagy markers: microtubule-associated light chain 3 Ⅱ (LC3-Ⅱ) and p62; the former usually increases and the latter decreases if autophagy is activated.Significant LV reverse remodeling was observed early after SVR. On the other hand, the 28th postoperative day SVR + trehalose was associated with smaller LVEDD and better FS than SVR alone (LVEDD, P = 0.043; FS, P < 0.01). LC3-Ⅱ increased comparably in both groups, while p62 was significantly lower in the SVR + trehalose group than in the SVR alone group (P < 0.01). In conclusion, trehalose attenuated the recurrence of LV remodeling and changed autophagy markers after SVR in rats with ICM. Trehalose may be a candidate for adjuvant therapy to retain the effects of SVR.

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“…However, late after SVR, LV remodeling recured as the level of the rats without SVR. These findings do not conflict with the clinical reports of SVR [12,13].…”

Section: Attenuation Of Recurrence Of LV Remodeling After Svrsupporting

confidence: 73%

“…In other studies, one of the concerns has been reported to be recurrence of LV remodeling after SVR [12,13]. These studies demonstrated that LV size increased again at 1 year after SVR.…”

Section: Introductionmentioning

confidence: 84%

Section: Autophagy: a Mechanism Of Trehalose Effect?mentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

et al. 2022

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“…2 , 11 In most cases, the cause of repeated postoperative LV remodeling is myocardial inflammation. 10 , 11 Nevertheless, with a careful analysis of the history of SVR technique development, attention is drawn to the observance of normal geometry and structure of the heart, thereby showing that the best results are achieved when the SVR procedure is aimed at restoring the elliptical shape, and not just at a smaller size and volume of the LV. 3 , 4 , 8 At the same time, indications for SVR should also be carefully considered, and an individual approach should be taken in each case.…”

Section: Discussionmentioning

confidence: 99%

Results of reconstructive interventions in patients with ischemic cardiomyopathy

Шипулин

Pryakhin

Андреев

et al. 2020

Asian Cardiovasc Thorac Ann

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Background Effective treatment of patients with ischemic cardiomyopathy is one of the most difficult issues in contemporary cardiac surgery. The aim of this study was to evaluate the long-term effectiveness of reconstructive interventions on the left ventricle during chronic heart failure in patients with ischemic cardiomyopathy. Methods Between March 2013 and December 2017, 178 patients underwent surgical treatment for ischemic cardiomyopathy. Isolated coronary artery bypass grafting was compared with coronary artery bypass grafting with left ventricular reconstruction, using propensity score matching analysis. The primary endpoints of the study were hospital mortality and long-term survival. Results After propensity score matching, 29 pairs of patients were compared. The 30-day hospital mortality was comparable (6.8% versus 6.8%, p = 0.952), the average follow-up was 37.4 ± 12.6 months, with no statistically significant difference in mortality from all causes ( p = 0.352). After coronary artery bypass in combination with left ventricular reconstruction, patients showed a statistically significant decrease in clinical and functional indicators of chronic heart failure compared to those who had coronary artery bypass grafting alone, in terms of peak oxygen consumption (15.3 versus 13.5 mL·kg−1·min−1, p = 0.043) and N-terminal pro-brain natriuretic peptide concentrations (298.6 versus 461.1 pg·mL−1, p = 0.032). Conclusions Compared to isolated coronary artery bypass, coronary artery bypass in combination with left ventricular reconstruction for the treatment of ischemic cardiomyopathy leads to a significant decrease in the clinical and functional parameters of chronic heart failure in the long-term postoperative period.

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Surgical Treatment of Advanced Heart Failure: Alternatives to Heart Transplantation and Mechanical Circulatory Assist Devices

George

Arnaoutakis

Shah

2011

Progress in Cardiovascular Diseases

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Causes of repeated remodeling of left ventricle after Dor procedure

Abstract: Thus, a combination of the foregoing features is a morphological predictor of postoperative heart remodeling in patients with ICMP.

Cited by 3 publications

References 15 publications

Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy

Results of reconstructive interventions in patients with ischemic cardiomyopathy

Surgical Treatment of Advanced Heart Failure: Alternatives to Heart Transplantation and Mechanical Circulatory Assist Devices

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