Results of reconstructive interventions in patients with ischemic cardiomyopathy

Abstract

Background Effective treatment of patients with ischemic cardiomyopathy is one of the most difficult issues in contemporary cardiac surgery. The aim of this study was to evaluate the long-term effectiveness of reconstructive interventions on the left ventricle during chronic heart failure in patients with ischemic cardiomyopathy. Methods Between March 2013 and December 2017, 178 patients underwent surgical treatment for ischemic cardiomyopathy. Isolated coronary artery bypass grafting was compared with coronary artery bypass grafting with left ventricular reconstruction, using propensity score matching analysis. The primary endpoints of the study were hospital mortality and long-term survival. Results After propensity score matching, 29 pairs of patients were compared. The 30-day hospital mortality was comparable (6.8% versus 6.8%, p = 0.952), the average follow-up was 37.4 ± 12.6 months, with no statistically significant difference in mortality from all causes ( p = 0.352). After coronary artery bypass in combination with left ventricular reconstruction, patients showed a statistically significant decrease in clinical and functional indicators of chronic heart failure compared to those who had coronary artery bypass grafting alone, in terms of peak oxygen consumption (15.3 versus 13.5 mL·kg−1·min−1, p = 0.043) and N-terminal pro-brain natriuretic peptide concentrations (298.6 versus 461.1 pg·mL−1, p = 0.032). Conclusions Compared to isolated coronary artery bypass, coronary artery bypass in combination with left ventricular reconstruction for the treatment of ischemic cardiomyopathy leads to a significant decrease in the clinical and functional parameters of chronic heart failure in the long-term postoperative period.

Analysis of susceptibility genes and myocardial infarction risk correlation of ischemic cardiomyopathy based on bioinformatics

“…The pathogenesis of ICM is still not fully understood. Several studies (10,11) have shown that inflammation, apoptosis, myocardial fibrosis, and other pathological changes play an important role in the occurrence and development of ICM. We present the following article in accordance with the STREGA reporting checklist (available at https://jtd.amegroups.com/article/ view/10.21037/jtd-22-1060/rc).…”

Predictive Effect of Triglyceride-Glucose Index on Adverse Prognostic Events in Patients with Type 2 Diabetes Mellitus and Ischemic Cardiomyopathy

“… 2 Ischemic cardiomyopathy (ICM) is linked to myocardial insufficiency and inadequate perfusion caused by obstructive CAD. 3 Furthermore, end-stage HF frequently stems from ICM, which can result in a significant decrease in the left ventricular ejection fraction (LVEF). 4 , 5 HF refers to clinical syndromes characterized by pulmonary and/or body circulation stasis.…”