Causes et caractéristiques des décès des patients infectés par le VIH-1, en succès immuno-virologique sous traitement antirétroviral

May, Thierry; Lewden, Charlotte; Bonnet, Fabrice; Héripret, Laurence; Bévilacqua, S.; Jougla, Éric; Costagliola, Dominique; Morlat, Philippe; Salmon, Dominique; Chêne, Geneviève

doi:10.1016/s0755-4982(04)98968-3

Cited by 17 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the Post-HAART era, from 1997 to 2020, the completed suicide prevalence rate was 8.7% to 7.6% in the United States [ 17 , 33 , 47 , 52 , 70 , 84 , 86 , 87 ]; 12.9% to 7% in the United Kingdom [ 88 , 91 , 102 , 104 , 107 , 113 ]; 6% to 4.1% in France [ 81 , 83 , 95 , 108 , 111 ]; 1.48% in Greece [ 110 ]; 0.6%–1.3% in Spain [ 90 , 117 ]; 4% to 6.2% in Germany [ 114 , 136 ]; 6% to 1% [ 104 , 105 , 120 ]; 4% in Australia [ 196 ]; 7% to 8.2% in Canada [ 16 , 61 ]; 7.8% in Japan [ 184 ]; 5.5% in Taiwan [ 163 ]; 15.5% in Thailand [ 168 ]; and 38.6% in Denmark [ 94 ]. The death due to suicide incidence rate went from 0.03 per 100 person years in 2010 to 0.47 in 2016 in Canada [ 16 , 61 ], 0.16 per 100 person-years in Switzerland [ 5 ], and was 0.04 per 100 person years in 2015 to 0.02 in 2017 in UK [ 102 , 107 ] ( S3 Table ).…”

Section: Resultsmentioning

confidence: 99%

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

Tsai

Mudiyanselage

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Death by suicide is a major public health problem. People living with human immunodeficiency virus (PLHIV) have higher risk of suicidal behavior than the general population. The aim of this review is to summarize suicidal behavior, associated risk factors, and risk populations among PLHIV. Research studies in six databases from January 1, 1988, to July 8, 2021, were searched using keywords that included “HIV,” “suicide,” and “risk factors.” The study design, suicide measurement techniques, risk factors, and study findings were extracted. A total of 193 studies were included. We found that the Americas, Europe, and Asia have the highest rates of suicidal behavior. Suicide risk factors include demographic factors, mental illness, and physiological, psychological, and social support. Depression is the most common risk factor for PLHIV, with suicidal ideation and attempt risk. Drug overdosage is the main cause of suicide death. In conclusion, the current study found that PLHIV had experienced a high level of suicidal status. This review provides an overview of suicidal behavior and its risk factors in PLHIV with the goal of better managing these factors and thus preventing death due to suicide.

show abstract

Section: Resultsmentioning

confidence: 99%

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

Tsai

Mudiyanselage

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Within the French Hospital Database on HIV Infection (FHDH), the incidence of systemic NHL has decreased between 1993 and 1994 and between 1997 and 1998, from 8.6 per 1,000 to 4.3 per 1,000 person-years, respectively 3; the incidence in the same cohort was 2.8 per 1,000 person-years in 2006. This is consistent with reports of decreased incidence of HIV-related NHL in the post HAART era from the U.K., Australia, California4.…”

Section: Epidemiology Of Aids Related Lymphomasmentioning

confidence: 99%

EBV and HIV-Related Lymphoma

Bibas¹,

Antinori²

2009

Medit J Hemat Infect Dis

View full text Add to dashboard Cite

HIV-associated lymphoproliferative disorders represent a heterogeneous group of diseases, arising in the presence of HIV-associated immunodeficiency. The overall prevalence of HIV-associated lymphoma is significantly higher compared to that of the general population and it continues to be relevant even after the wide availability of highly active antiretroviral therapy (HAART) (1). Moreover, they still represent one of the most frequent cause of death in HIV-infected patients. Epstein–Barr virus (EBV), a γ-Herpesviruses, is involved in human lymphomagenesis, particularly in HIV immunocompromised patients. It has been largely implicated in the development of B-cell lymphoproliferative disorders as Burkitt lymphoma (BL), Hodgkin disease (HD), systemic non Hodgkin lymphoma (NHL), primary central nervous system lymphoma (PCNSL), nasopharyngeal carcinoma (NC). Virus-associated lymphomas are becoming of significant concern for the mortality of long-lived HIV immunocompromised patients, and therefore, research of advanced strategies for AIDS-related lymphomas is an important field in cancer chemotherapy. Detailed understanding of the EBV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy The linkage of HIV-related lymphoma with EBV infection of the tumor clone has several pathogenetic, prognostic and possibly therapeutic implications which are reviewed herein.

show abstract

“…Ces complications cardiovasculaires sont greffées d'une mortalité lourde. Elles ont été citées comme la 3 ème cause de décès chez les PVVIH sous ARV en succès immuno-virologique en France en 2004 (May et al, 2004).…”

Section: Introductionunclassified

Risque cardiovasculaire chez les adultes vivant avec le virus d’immunodéficience humaine et sous traitement antirétroviral à Parakou au Bénin

Attinsounon¹,

Codjo²,

Ahouansou³

et al. 2020

Int. J. Bio. Chem. Sci

View full text Add to dashboard Cite

Les personnes vivant avec le Virus de l’Immunodéficience Humain (VIH) présentent des complications métaboliques qui sont généralement multifactorielles. Elles sont associées à un risque élevé de morbidité et de mortalité cardiovasculaires. L’objectif de cette étude était d’évaluer le niveau de risque cardiovasculaire et les facteurs associés chez les personnes vivant avec le VIH. Il s’agissait d’une étude transversale, descriptive à visée analytique conduite sur une période de six mois allant du 1er Février au 31 Juillet 2016. Un recrutement systématique a permis d’inclure des patients âgés de plus de 15 ans, VIH positif, sous traitement antirétroviral et suivis à l’hôpital universitaire départemental de Borgou. Le risque cardiovasculaire (RCV) a été évalué selon le score de Framingham qui a permis de classer les patients en deux groupes : les patients ayant un RCV mineur (score < 10%) et ceux ayant un RCV majeur (score ≥ 10%). La régression binominale en analyse univariée et multivariée a été utilisée pour identifier les facteurs associés au risque cardiovasculaire. Tous les tests statistiques ont été réalisés avec un seuil de significativité de 5% et un intervalle de confiance de 95%. Au total, 215 PVVIH ont été inclus dans cette étude sur les 2365 patients suivis au CHUD Borgou. L’âge moyen était de 43,65 ± 11,38 ans avec les extrêmes de 19 et 75 ans. Le sexe féminin était prédominant (146 soit 67,91%) avec une sex-ratio (H/F) de 0,47. Un risque cardiovasculaire majeur était présent chez 56 patients (26,05%). Les facteurs associés au RCV majeur en analyse univariée étaient le sexe féminin (p = 0,019), la consommation du tabac (p = 0,003), le diabète (p < 0,001), l’hypertension artérielle (p < 0,001), le syndrome métabolique (p < 0,001) et l’exposition à l’association Lopinavir/ritonavir (p = 0,011). La prise de Zidovudine avait un effet protecteur (p = 0,008). En analyse multivariée, les facteurs associés au RCV majeur étaient le sexe féminin (p = 0,0001), le tabagisme (p = 0,02) et la présence du diabète (p = 0,0003). Les patients infectés par le VIH suivis à Parakou présentent plusieurs facteurs de risque cardiovasculaire. Ce risque doit être prévenu par la prescription des mesures hygiéno-diététiques et l’instauration d’un suivi cardiologique régulier. © 2019 International Formulae Group. All rights reserved Mots clés: VIH, Risque cardiovasculaire, traitement antirétroviral, Parakou English Title: Cardiovascular risk in adults living with the human immunodeficiency virus and on antiretroviral therapy in Parakou English Abstract People living with HIV have metabolic complications that are usually multifactorial. They are associated with a high risk of cardiovascular morbidity and mortality. The objective of this study was to assess the level of cardiovascular risk and associated factors in people living with HIV. This was a cross-sectional, descriptive and analytically study conducted from February to July 2016 at the Teaching and Regional Hospital of Borgou. Systematic enrolment included patients older than 15 years, HIV positive, and followed up under antiretroviral therapy. Cardiovascular risk (CVR) was assessed according to the Framingham score, which classified patients into two groups: patients with a minor CVR (score <10%) and those with a major CVR (score ≥ 10%). Binomial regression in univariate and multivariate analysis are used to identify associated factors with cardiovascular risk. A total of 215 PLHIV were included in this study on the 2365 patients monitored at CHUD Borgou. The average age was 43.65 ± 11.38 years. Females were predominant (146, 67.91%) with a sex-ratio of 0.47. A major cardiovascular risk was present in 56 patients (26.05%). The factors associated with major CVR in univariate analysis were female gender (p = 0.019), tobacco use (p = 0.003), diabetes (p < 0.001), high blood pressure (p < 0.001), metabolic syndrome (p < 0.001), and exposure to lopinavir/ritonavir combination (p = 0.011). Exposure to zidovudine had a protective effect (p = 0.008). In multivariate analysis, factors associated with major CVR were female gender (p = 0.0001), smoking (p = 0.02), and presence of diabetes (p = 0.0003). HIV-infected patients in Parakou have several cardiovascular risk factors. This risk must be prevented by prescribing diet and lifestyle measures and instituting regular cardiological follow-up. © 2019 International Formulae Group. All rights reserved Keywords: HIV, cardiovascular risk, antiretroviral therapy, Parakou

show abstract

Causes et caractéristiques des décès des patients infectés par le VIH-1, en succès immuno-virologique sous traitement antirétroviral

Cited by 17 publications

References 18 publications

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

Global overview of suicidal behavior and associated risk factors among people living with human immunodeficiency virus: A scoping review

EBV and HIV-Related Lymphoma

Risque cardiovasculaire chez les adultes vivant avec le virus d’immunodéficience humaine et sous traitement antirétroviral à Parakou au Bénin

Contact Info

Product

Resources

About