Causes and Risk Factors for Male Infertility: A Scoping Review of Published Studies

Okonofua, Friday; Ntoimo, Lorretta; Omonkhua, Akhere; Ayodeji, Oladiran; Olafusi, Celestina; Unuabonah, Emmanuel I.; Ohenhen, Victor

doi:10.2147/ijgm.s363959

Cited by 43 publications

(28 citation statements)

References 69 publications

(76 reference statements)

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“…In addition, an insightful review has summarized that there are potential associations between male infertility and the risk of chronic disease, co-morbidities, cardiovascular disease and cancer development, so male infertility will have more possibilities as a biomarker of future health and mortality ( 4 ). Common causes and risk factors for male infertility have been postulated and/or confirmed in various studies, including smoking, alcohol consumption, drugs, obesity, past or current testicular infections, exposure to environmental toxins, testicular exposure to excessive heat, hormonal disorders, testicular trauma, and ejaculation/erectile dysfunction ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study

Dai

Guo²,

Zhu³

et al. 2022

Front. Endocrinol.

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Abnormal spermatozoa can not only reduce the fertilization rate, but also prolong the natural conception time and even increase the risk of spontaneous miscarriage. Diabetes mellitus (DM) has become a major global health problem, and its incidence continues to rise, while affecting an increasing number of men in their reproductive years. Type 2 Diabetes Mellitus (T2DM), accounting for about 85-95% of DM, is closely related to the development of sperm. However, the exact association between T2DM and abnormal spermatozoa remains unclear. Herein, we designed a Two-sample Mendelian randomization (MR) study to explore the causal association between T2DM and abnormal spermatozoa risk in European population data which come from the GWAS summary datasets. We selected 9 single nucleotide polymorphisms (SNPs) of T2DM (exposure data) as instrumental variables (IVs), and then retrieved the suitable abnormal spermatozoa genome-wide association study (GWAS) data of European from Ieu Open GWAS Project database which includes 915 cases and 209,006 control as the outcome data. Our results indicate that strict T2DM might not result in a higher risk of abnormal spermatozoa genetically in Europeans (OR: 1.017, 95% confidence interval (CI): 0.771-1.342, p=0.902). Our findings demonstrate that only T2DM may not explain the relatively higher risk of abnormal spermatozoa in men with it in Europeans. In subsequent studies, more comprehensive and larger samples need to be studied to reveal the relationship and potential mechanism between T2DM and abnormal spermatozoa.

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Section: Introductionmentioning

confidence: 99%

Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study

Dai

Guo²,

Zhu³

et al. 2022

Front. Endocrinol.

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“…Male infertility has been attributed to several factors, including problems in spermatozoa caused by insufficient numbers (azoospermia/oligospermia), poor motility and incorrect structure/morphology. Systematic drops in sperm counts have been noted in some articles [5,6] . Based on Okonofua et al study, four broad causes and risk factors of male infertility identified were biological/physiological/genetic causes; behavioral/lifestyle risk factors; environmental factors and socio-demographic risk factors [5] .…”

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confidence: 95%

“…Systematic drops in sperm counts have been noted in some articles [5,6] . Based on Okonofua et al study, four broad causes and risk factors of male infertility identified were biological/physiological/genetic causes; behavioral/lifestyle risk factors; environmental factors and socio-demographic risk factors [5] . The genetic and biological factors in male infertility that have been identified so far include chromosomal disorders, monogenic diseases, meiosis and endocrine disorders [7] .…”

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confidence: 95%

Investigating the Relationship between Tumor Necrosis Factor Alpha-308 and Interleukin-1beta C+3953T Polymorphisms with Male Fertility in Erbil Province

Mustafa¹,

Al-khayat²

2022

IJPS

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Mustafa et al.: Relationship between Tumor Necrosis Factor Alpha-308 and Interleukin-1beta C+3953T Polymorphisms with Male FertilityMale infertility is influenced by psychological, biological and environmental factors. Nowadays, the morphological change of genes and biological molecules are the focus of attention. Therefore, this study was conducted with the aim of investigating the relationship between tumor necrosis factor alpha-308 and interleukin-1beta C+3953T polymorphisms with male fertility in Erbil province. This study was conducted between 2020 and 2021 on 270 men who referred to the infertility center in Erbil, Iraq, with infertility problems. The sampling was purposeful and the samples were divided into three groups of 90 people with the characteristics of the first group without fertility problems, the second group with primary infertility and the third group with secondary infertility. Blood samples were taken from each sample and the samples were sent to the laboratory for deoxyribonucleic acid extraction and allele analysis. A polymerase chain reaction machine was used for this purpose. Statistical package for the social sciences version 23 software and descriptive statistical tests, chi-square, odds ratio and conditional regression were used to analyze the obtained data. The results of tumor necrosis factor alpha-308 genotype showed the frequency of alleles in three groups of men, it can be concluded that there is a significant difference between the three groups of men in terms of mutation frequency and fertility (p≤0.001). The results of interleukin-1beta C+3953T genotype have shown that there is a significant difference in mutation frequency and finally fertility in three groups of men (p≤0.001). The tumor necrosis factor alpha-308 genotype GA and GG alleles have a significant relationship with male fertility. In genotype interleukin-1beta C+3953T, CT and CC alleles have a significant relationship with male fertility. The results of this study showed that tumor necrosis factor alpha-308 genotype and interleukin-1beta C+3953T genotype were identified as important risk factors in male infertility.

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“…Inadequate numbers (oligospermia/azoospermia), impaired motility, and defective morphology of spermatozoa have been reported as leading causes of male infertility. [1][2][3][4][5] Semen analysis is mainstay in the evaluation of male infertility. Additionally, advanced diagnostic tests to investigate sperm quality are on a rise and can improve diagnosis and management.…”

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confidence: 99%

“…2 Male infertility is often poorly responsive to primary treatment and is frequently tackled using secondary measures like intra-uterine insemination, in vitro fertilization, intra-cytoplasmic sperm transfer, and child adoption. [5][6][7] This study was undertaken to help understand the causes and risk factors responsible for male infertility thereby enabling the identification of effective methods for its primary treatment.…”

mentioning

confidence: 99%

Insight into epidemiology of male infertility in central India

Agarwal

Srivastava

Fathima

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Approximately 10% to 15% of couples in developing countries are infertile. Male infertility is responsible for 20-43% of infertility cases and contributes to another 12-20% of cases. Azoospermia, oligozoospermia, asthenozoospermia, teratozoospermia, and oligoasthenoteratozoospermia are abnormal sperm parameters causing male infertility. Male infertility is often poorly responsive to primary treatment and often requires supportive secondary measures. The understanding of causes and modifiable risk factors for male infertility would enable their prevention and primary treatment. Aims and objectives of current study was to analyze the epidemiology and clinical factors of male infertility in Central India and identify its risk factors.Methods: 100 male patients attending outpatient for treatment of infertility were evaluated using a questionnaire. Semen samples were collected and spermatozoa were assessed according to WHO 2021 data for semen analysis. The results were tabulated and analyzed.Results: Amongst patients were semen abnormalities, the majority (34%) of patients had oligoasthenoteratozoospermia. All semen abnormalities were most common in the age group 35-45 years and in patients with 5-10 years duration of infertility. All semen abnormalities except azoospermia were most common in people with a monthly income of >2,000-5,000. The majority of the patients had a past history of urogenital tract infection, except oligoasthenospermic males in whom the majority had varicocele. All semen abnormalities were more common among businessmen and also more prevalent among smokers.Conclusions: Couples should be educated about infertility causes and the contribution of male infertility to it. Multifactorial analysis along with clinicopathological analysis should contribute to accurate diagnosis of the cause of male infertility and proposal of adequate measures.

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Causes and Risk Factors for Male Infertility: A Scoping Review of Published Studies

Cited by 43 publications

References 69 publications

Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study

Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study

Investigating the Relationship between Tumor Necrosis Factor Alpha-308 and Interleukin-1beta C+3953T Polymorphisms with Male Fertility in Erbil Province

Insight into epidemiology of male infertility in central India

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