Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing

Yuan, Jingfeng; Zhang, Dong; He, Xiaomin; Ni, Yifeng; Che, Lingbin; Wu, Jiang; Wu, Baoyi; Wang, Yan; Wang, Shuguang; Sha, Dongyong; Zheng, Si Yu; Yang, Jintao

doi:10.1016/j.ijbiomac.2021.09.019

Cited by 30 publications

(20 citation statements)

References 48 publications

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“…Moreover, robust methods that allow hydrogel functionalization with a wide number of bioactive molecules, as well as the ability to incorporate different nanomaterials inside hydrogels, enabling the design of multi-functional platforms to fabricate advanced materials and composites have been investigated [ 19 , 20 , 21 , 22 ]. Apart from the above-mentioned features, some peptide hydrogels possess intrinsic antimicrobial and anti-inflammatory properties that may provide a synergistic effect when impregnated with antibiotics or nano-based antimicrobials [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Green In Situ Synthesis of Silver Nanoparticles-Peptide Hydrogel Composites: Investigation of Their Antibacterial Activities

Binaymotlagh

Giudice

Mignardi

et al. 2022

Gels

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The present paper investigated the synthesis of peptide-based hydrogel composites containing photo-generated silver nanoparticles (AgNPs) obtained in the presence and absence of honey as tensile strength enhancer and hydrogel stabilizer. Fmoc-Phe and diphenylalanine (Phe2) were used as starting reagents for the hydrogelator synthesis via an enzymatic method. In particular, we developed an in situ one-pot approach for preparing AgNPs inside peptide hydrogels using a photochemical synthesis, without any toxic reducing agents, with reaction yields up to 30%. The structure and morphology of the nanohybrids were characterized with different techniques such as FESEM, UV-Vis, DLS, SAXS and XPS. Moreover, the antibacterial activity of these hybrid biomaterials was investigated on a laboratory strain and on a clinical isolate of Staphylococcus aureus. Results demonstrated that honey increased both swelling ability and also mechanical stability of the hydrogel. Finally, a higher antibacterial effect of AgNPs in the hybrid was observed in the presence of honey. In particular, AgNPs/hgel and AgNPs/hgel-honey showed an enhanced antibacterial activity (3.12 mg/L) compared to the free form of AgNPs, alone or in combination with honey (6.25 mg/L) for both S. aureus strains.

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Section: Introductionmentioning

confidence: 99%

Green In Situ Synthesis of Silver Nanoparticles-Peptide Hydrogel Composites: Investigation of Their Antibacterial Activities

Binaymotlagh

Giudice

Mignardi

et al. 2022

Gels

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“…Several properties of hydrogels represent ideal dressings, such as hydrogel dressings could absorb wound exudate and preserve a moist environment of the wound area [1]. Nowadays, abundant hydrogel dressings are designed with the ideal dressing properties, for instance, cationic peptide-based salt-responsive antibacterial hydrogel dressings [2] and poly [3-(dimethyl(4-vinylbenzyl) ammonium) propyl sulfonate] (SVBA) in poly-acrylamide network hydrogel dressings (poly(AAm-co-SVBA) [3].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimal Design of Dioscorea bulbifera and Honey-Loaded Gantrez®/Xyloglucan Hydrogel as Wound Healing Patches

et al. 2022

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Hydrogel patches are some of the most effective dressings for wound healing. In this study, the Gantrez® S-97 (Gan)/xyloglucan (XG) hydrogel patches were formulated by using a full central composite design (CCD). The optimized hydrogel patches consisted of 17.78% w/w of Gan and 0.1% w/w of XG. Honey and D. bulbifera extract were loaded in the Gan/XG hydrogel patches. The physical properties of the hydrogel patches, including water content, water absorption, rate of water vapor transmission, and mechanical properties, were examined. The D. bulbifera extract/honey-loaded patch exhibited a higher value of water absorption, tensile strength, and elongation than the honey-loaded patch and the unloaded patch, respectively. The biological activities of the patches were also investigated. All hydrogel patches protected wounds from external bacterial infection. The D. bulbifera extract/honey-loaded patch exhibited stronger antioxidant activity than the honey-loaded patch and the unloaded patch. Besides, all the hydrogel patches with concentrations of 0.5–2.5 mg/mL showed that they were nontoxic to fibroblast cells. The combination of D. bulbifera extract and honey in the patch affected fibroblast proliferation. In addition, all Gan/XG hydrogel patches significantly induced recovery of the scratch area. Therefore, the Gan/XG hydrogel patches could be candidates as wound dressings.

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“…This hydrogel demonstrated excellent biocompatibility and showed elasticity-dominating properties, as well as a good antibacterial performance on Escherichia coli ( E. coli ). Yuan et al reported a one-pot synthesis of a cationic peptide hydrogel, which is salt-responsive with antifouling and bactericidal character, and contains ε -poly-L-lysine, poly (ethylene glycol) diglycidyl ether, and poly(DVBAPS-co-GMA) via a one-pot method [ 113 ]. The structure of these biocompatible hydrogels has the flexibility to quaternize for enhancing the antibacterial property.…”

Section: Biomedical Applications Of Peptide-based Hydrogelsmentioning

confidence: 99%

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

et al. 2022

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Peptide-based hydrogels have attracted increasing attention for biological applications and diagnostic research due to their impressive features including biocompatibility and biodegradability, injectability, mechanical stability, high water absorption capacity, and tissue-like elasticity. The aim of this review will be to present an updated report on the advancement of peptide-based hydrogels research activity in recent years in the field of anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering, and vaccines. Additionally, the biosensing applications of this key group of hydrogels will be discussed mainly focusing the attention on cancer detection.

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Cationic peptide-based salt-responsive antibacterial hydrogel dressings for wound healing

Cited by 30 publications

References 48 publications

Green In Situ Synthesis of Silver Nanoparticles-Peptide Hydrogel Composites: Investigation of Their Antibacterial Activities

Green In Situ Synthesis of Silver Nanoparticles-Peptide Hydrogel Composites: Investigation of Their Antibacterial Activities

Formulation and Optimal Design of Dioscorea bulbifera and Honey-Loaded Gantrez®/Xyloglucan Hydrogel as Wound Healing Patches

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

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