Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study

Dennison, Olivia; Gao, Jie; Lim, Lee Wei; Stagg, Charlotte J.; Aquili, Luca

doi:10.1016/j.brs.2018.12.001

Cited by 22 publications

(20 citation statements)

References 54 publications

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“…We checked for the potential mood effects induced by tyrosine intake by administering a computerized adaptation of the visual analog scale (VAS) which was programmed and run in PEBL 66 , and has previously been used by our research group 67–69 . The scale consists of seven dimensions (e.g.…”

Section: Methodsmentioning

confidence: 99%

Fear expression is suppressed by tyrosine administration

Soranzo

Aquili

2019

Sci Rep

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Animal studies have demonstrated that catecholamines regulate several aspects of fear conditioning. In humans, however, pharmacological manipulations of the catecholaminergic system have been scarce, and their primary focus has been to interfering with catecholaminergic activity after fear acquisition or expression had taken place, using L-Dopa, primarily, as catecholaminergic precursor. Here, we sought to determine if putative increases in presynaptic dopamine and norepinephrine by tyrosine administered before conditioning could affect fear expression. Electrodermal activity (EDA) of 46 healthy participants (24 placebo, 22 tyrosine) was measured in an instructed fear task. Results showed that tyrosine abolished fear expression compared to placebo. Importantly, tyrosine did not affect EDA responses to the aversive stimulus (UCS) or alter participants’ mood. Therefore, the effect of tyrosine on fear expression cannot be attributed to these factors. Taken together, these findings provide evidence that the catecholaminergic system influences fear expression in humans.

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Section: Methodsmentioning

confidence: 99%

Fear expression is suppressed by tyrosine administration

Soranzo

Aquili

2019

Sci Rep

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“…The primary goal of this study was to extend our recent work [22], in which we found that combining cathodal tDCS of the dlPFC (which by itself impaired cognitive flexibility) with tyrosine administration (which by itself improved cognitive flexibility) resulted in cognitive flexibility performance on par with the control condition (sham tDCS + placebo). These results suggested that increasing dopaminergic tone could counteract the detrimental effects of inhibitory cathodal tDCS of the dlPFC.…”

Section: Discussionmentioning

confidence: 93%

“…We first analysed changes in the proportion of perseverative errors across conditions. As in our previous study [22], we measured a change in the performance from baseline (T1) to post (Fig. 1F).…”

Section: Anodal Tdcs and Dopamine Depletion Modulate Changes In Taskmentioning

confidence: 94%

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Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC

et al. 2019

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“…Finally, our tDCS findings in relation to anodal stimulation of the dlPFC, the APTD and cognitive flexibility (task-switching), 124 were replicated in another study where tyrosine administration improved cognitive flexibility (over placebo), but this effect could be ‘nullified’ by cathodal (inhibitory) stimulation of the dlPFC. 135 …”

Section: The Role Of Tyrosine In Executive Functionsmentioning

confidence: 99%

The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing

Aquili

2020

Int J�Tryptophan�Res

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The serotonergic precursor tryptophan and the dopaminergic precursor tyrosine have been shown to be important modulators of mood, behaviour and cognition. Specifically, research on the function of tryptophan has characterised this molecule as particularly relevant in the context of pathological disorders such as depression. Moreover, a large body of evidence has now been accumulated to suggest that tryptophan may also be involved in executive function and reward processing. Despite some clear differentiation with tryptophan, the data reviewed in this paper illustrates that tyrosine shares similar functions with tryptophan in the regulation of executive function and reward, and that these processes in turn, rather than acting in isolation, causally influence each other.

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Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study

Abstract: Catecholaminergic modulation of indices of cognitive flexibility:a pharmaco-tDCS study. Brain Stimulation. (In Press

Cited by 22 publications

References 54 publications

Fear expression is suppressed by tyrosine administration

Fear expression is suppressed by tyrosine administration

Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC

The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing

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