Catatonia induced by levetiracetam

Catatonia: A Review

“…Neurological conditions like epilepsy, strokes of the anterior brain region and traumatic brain injury may also present with catatonia (9). Withdrawal from drugs like benzodiazepines, L-dopa, gabapentin and overdose with street drugs like LSD, PCP, cocaine, Ecstasy, disulfiram (18) levetiracetam can result in catatonia (9,(18)(19)(20)(21). A retrospective study tried to identify clinical characteristics that could differentiate catatonia caused by psychiatric conditions from the one caused by medical conditions.…”

“…Adolescents, males and those of non-European origin were over-represented in cases presenting with catatonia in this age group (24). Tables 1 and 2 indicate the prevalence and common conditions associated with catatonia (1,(7)(8)(9)13,(17)(18)(19)(20)(21)25,29).…”

“…Although catatonia is less frequently described in childhood, it has been associated with autism and pervasive developmental disorders, childhoodonset schizophrenia and previous treatment with ECT (24). 9,13,29 Bipolar disorder-manic or mixed episodes Major depressive disorder Medical conditions 8,9 Endocrine abnormalities, infections, electrolyte imbalances Neurological conditions 8,9 Epilepsy, strokes, traumatic brain injury, multiple sclerosis, encephalitis Drugs 8,9,[18][19][20][21] Withdrawal …”

Nalbuphine-induced psychosis treated with naloxone

“…18 There are several cases of levetiracetaminduced psychosis and catatonia in the literature. [19][20][21][22][23] It has also been documented that high doses of anticholinergic agents, such as diphenhydramine, can produce perceptual and mood-altering states 24,25 ; in the case reported here, the onset and resolution of the psychotic event occurred despite continuation of these medications. Further, administration of the concomitant medications did not correlate with symptom development in this patient (nalbuphine was the only medication administered proximal to the event), and these medications were used before and after the psychotic event, making an association unlikely.…”

Efficacy and Tolerability of Levetiracetam (Keppra®) in the Treatment of Epilepsy: Review of Literature

“…Основные побочные эффекты, приводящие к отмене леветира-цетама: нарушение поведения и враждебность. Край-не редко встречаются психотические проявления [24,53,57,75], в том числе в рамках феномена насильст-венной нормализации [55]. По мнению многих иссле-дователей, частота поведенческих побочных эффектов при приеме леветирацетама выше у детей, чем у взро-слых; и у детей с предшествующими поведенческими или когнитивными нарушениями [43,53,57].…”