Nalbuphine-induced psychosis treated with naloxone

Siemianowski, Laura A.; Rosenheck, J.; Whitman, Craig

doi:10.2146/ajhp130485

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…There was another case of a 25 year old female with history of SLE developed an acute psychotic reaction secondary to administration of nalbuphen IV for opioid induced pruritus [21]. There are also some Case reports of psychosis published with opioid medications are related to opioid withdrawal [22,23].…”

Section: Discussionmentioning

confidence: 99%

Oral Hydrocodone Induced Acute Psychosis in an Adult Male: A CaseReport.

Rasheed¹,

Baronia²,

Sharma³

et al. 2015

J Clin Case Rep

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Hydrocodone is an opioid derived from codeine, which has been used for many years as a short-acting analgesic combined with acetaminophen (or less commonly ibuprofen). Common and severe psychiatric side effects included include mental depression, mood changes, hallucination, delirium, somnolence, agitation, and dysphoria. This is a report of a particular case that resulted in acute psychosis after immediately starting on Hydrocodone because of back pain in a 35 year old male, with no past psychiatrist history. The patient returned to his baseline mental status after the hydrocodone was discontinued. Earlier research was published about these symptoms are the ones where hydrocodone was used in combination with other drugs, but in this unique case the patient was not any other medication except the hydrocodone. This unique case showed an association between the short term use of hydrocodone and development of psychiatric symptoms. Recognition of these uncommon psychiatric side effects of hydrocodone usage will allow for early recognition of their etiology, symptoms and treatment. Psychotic symptoms induce by analgesics are not a common condition but they still remain under diagnosed and untreated.

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Section: Discussionmentioning

confidence: 99%

Oral Hydrocodone Induced Acute Psychosis in an Adult Male: A CaseReport.

Rasheed¹,

Baronia²,

Sharma³

et al. 2015

J Clin Case Rep

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show abstract

“…However, the question remains open. In 2014, there was a case of using naloxone to treat psychosis, which emerged after the use of nalbuphine in a patient who was not a drug user [35]. This case was described as an unusual manifestation of side effects.…”

Section: Nalbuphine and Addictionmentioning

confidence: 99%

Nalbuphine: some aspects of the research and applications

Logash¹,

Pokotylo²,

Zboina³

et al. 2017

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Nalbuphine hydrochloride is a synthetic, non-scheduled opioid agonist/antagonist analgesic, widely used across different branches of medicine. Despite the fact that nalbuphine has been used in the clinical setting for more than 40 years, there is still a lot of controversy regarding its mechanism of action and side-effects, including the development of the addiction to the drug. Recent data demonstrated the increase of non-medical use of nalbuphine. Moreover, in some countries it was placed in list of psychotropic and addictive substances. The increasing popularity of nalbuphine led us to review and analyse the data regarding both clinical and non-clinical applications of the drug. Furthermore, we performed an extensive analysis regarding available experimental models and approaches used in the research of opioid substances. Despite a set of problems in clinical settings due to the opioid nature of nalbuphine, it belongs to an indispensable group of analgesics for pain control. StreszczenieChlorowodorek nalbufiny jest syntetycznym, opioidowym agonistycznym i antagonistycznym lekiem przeciwbólowym, szeroko wykorzystywanych w różnych gałęziach medycyny. Mimo że nalbufina jest stosowana w postępowaniu klinicznym od ponad 40 lat nadal istnieje wiele kontrowersji dotyczących mechanizmu jej działania i skutków ubocznych, w tym uzależnienia od narkotyków. Ostatnie dane dowodzą zwiększonego niemedycznego wykorzystania nalbufiny. W niektórych krajach nalbufina została umieszczona w wykazie substancji psychotropowych i uzależniających. Wzrastające zastosowanie tego leku skłania do przeglądu i analizy danych dotyczących klinicznych i nieklinicznych jego aplikacji. Ponadto przeprowadzono analizę dotyczącą dostępnych modeli eksperymentalnych i podejść stosowanych w badaniach substancji opioidowych. Pomimo licznych problemów w praktyce klinicznej ze względu na opioidowy charakter nalbufina należy do grupy analgetyków niezbędnych w kontroli bólu.

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Free radical synthesis of cross-linking gelatin base poly NVP/acrylic acid hydrogel and nanoclay hydrogel as cephalexin drug deliver

Hajikarimi

Sadeghi

2020

J Polym Res

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Nalbuphine-induced psychosis treated with naloxone

Cited by 6 publications

References 29 publications

Oral Hydrocodone Induced Acute Psychosis in an Adult Male: A CaseReport.

Oral Hydrocodone Induced Acute Psychosis in an Adult Male: A CaseReport.

Nalbuphine: some aspects of the research and applications

Free radical synthesis of cross-linking gelatin base poly NVP/acrylic acid hydrogel and nanoclay hydrogel as cephalexin drug deliver

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