Cataract Extraction in the Collaborative Initial Glaucoma Treatment Study

Musch, David C.

doi:10.1001/archopht.124.12.1694

Cited by 90 publications

(25 citation statements)

References 22 publications

(21 reference statements)

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“…The Collaborative Initial Glaucoma Treatment Study (CIGTS) also found similar results. In this study, nonwhites (85% of whom were African Americans) had a 50% increased relative risk of having visual field progression compared with whites [36]. However, when interpreting findings such as these, it is important to keep in mind that the risk factors for developing glaucoma (family history, diabetes, and hypertension) do vary among different ethnic groups and therefore contribute in the different rates in prevalence and outcomes.…”

Section: Discussionmentioning

confidence: 78%

Ethnic differences in glaucoma: prevalence, management, and outcome

Wadhwa

Higginbotham

2005

Current Opinion in Ophthalmology

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Section: Discussionmentioning

confidence: 78%

Ethnic differences in glaucoma: prevalence, management, and outcome

Wadhwa

Higginbotham

2005

Current Opinion in Ophthalmology

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“…We previously reported that a subject’s race was not significantly associated with the risk or timing of CE. 12 …”

Section: Discussionmentioning

confidence: 99%

“…Given the impact that cataract has on VF and its association with trabeculectomy, 12 cataract was accounted for in the model as a time dependent variable indicating a visit within one year prior to cataract surgery. While the results address variables that were significant contributors to the models, other variables that were also assessed and found un-related included clinical center, gender, education, current smoking status, alcohol intake, family history of glaucoma, type of glaucoma, pupil response, iris color, optic disc hemorrhage, corneal thickness, and systemic hypertension.…”

Section: Methodsmentioning

confidence: 99%

Visual Field Progression in the Collaborative Initial Glaucoma Treatment Study

et al. 2009

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Purpose To evaluate factors associated with visual field (VF) progression, using all available follow-up through nine years after treatment initiation, in the Collaborative Initial Glaucoma Treatment Study (CIGTS). Design Longitudinal follow-up of participants enrolled in a randomized clinical trial. Participants 607 newly diagnosed glaucoma patients. Methods In a randomized clinical trial, 607 subjects with newly diagnosed open-angle glaucoma were initially treated with either medication or trabeculectomy. After treatment initiation and early follow-up, subjects were evaluated clinically at 6-month intervals. Study participants in both arms of the CIGTS were treated aggressively in an effort to reduce intraocular pressure (IOP) to a level at or below a predetermined, eye-specific target pressure. VF progression was analyzed using repeated measures models. Main outcome measures VF progression, measured by Humphrey 24-2 full threshold testing and assessed by the change in the mean deviation (MD), and an indicator of substantial worsening of the VF (MD decrease of ≥3 dB from baseline), assessed at each follow-up visit. Results Follow-up indicates minimal change from baseline in each initial treatment group’s average MD. However, at the eight year follow-up examination, substantial worsening (≥3 dB) of MD from baseline was found in 21.3% and 25.5% of the initial surgery and initial medicine groups, respectively. The effect of initial treatment on subsequent VF loss was modified by time (P<0.0001), baseline MD (P=0.03), and diabetes (P=0.01). Initial surgery led to less VF progression than initial medicine in subjects with advanced VF loss at baseline, whereas subjects with diabetes had more VF loss over time if treated initially with surgery. Conclusions The CIGTS intervention protocol led to a lowering of IOP that persisted over time in both treatment groups. Progression in VF loss was seen in a subset increasing to over 20% of the subjects. Our findings regarding initial surgery being beneficial for subjects who present at diagnosis with more advanced VF loss, but detrimental for patients with diabetes, are noteworthy and warrant independent confirmation.

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“…Hence, we used a setup that has proven reliable responses before [16,17]. The method has been described in detail before [12].…”

Section: Stimuli and Recordingmentioning

confidence: 99%