Catalpol alleviates ovalbumin-induced asthma in mice: Reduced eosinophil infiltration in the lung

Chen, Yanyan; Zhang, Yongzheng; Xu, Mingyuan; Luan, Junqi; Piao, Shengai; Chi, Shuang; Wang, Hai

doi:10.1016/j.intimp.2016.12.011

Cited by 31 publications

(24 citation statements)

References 35 publications

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“…The anti-inflammatory and antioxidant effects of catalpol are summarized in Table 1. The anti-inflammatory capability of catalpol was also observed in paw edema and broncho-alveolar lavage fluid of ovalbumin-induced mouse models [13,14]. A natural catalpol analogue, 6-O-veratroyl catalpol significantly inhibited the expression of the pro-inflammatory cytokines IL-1β and TNF-α in THP-1 macrophages stimulated with phorbol-12-myristate-13-acetate (PMA) [15].…”

Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 99%

“…Catalpol (5-10 mg/kg daily i.p.) alleviated inflammation of the airways and histopathological changes in the lungs of mice with ovalbumin-induced asthma; this was associated with the suppression of IL-4, IL-5, IL5Rα, and immunoglobulin E (IgE) [13]. Eosinophils have an important role in asthma and release toxic products at the sites of inflammation leading to airway remodeling and epithelial damage [18].…”

Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 99%

“…Eosinophils have an important role in asthma and release toxic products at the sites of inflammation leading to airway remodeling and epithelial damage [18]. Catalpol reduced pulmonary eosinophil infiltration and suppressed OVA-induced elevation of the eosinophil chemokine and its receptor CCR3, suggesting that catalpol hindered eosinophil recruitment and activation in asthmatic mice [13]. This antiasthmatic effect of catalpol in ovalbumin-induced asthma in mice was confirmed by Zou and colleagues who showed that in addition to preventing symptoms, catalpol treatment significantly reduced the total number of inflammatory cells and eosinophils in broncheoalveolar fluid; this was accompanied by a marked reduction in immunoglobin E (IgE) and inflammatory cytokines (IL-1 and IL-4) and a marked increase in interferon-γ (IN-γ).…”

Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 99%

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Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

et al. 2019

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Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very commonly used in Chinese and Korean traditional medicine for various disorders, including diabetes mellitus, neuronal disorders, and inflammation. Catalpol has been studied extensively for its biological properties both in vitro and in vivo. This review aims to appraise the biological effects of catalpol and their underlying mechanisms. An extensive literature search was conducted using the keyword “Catalpol” in the public domains of Google scholar, PubMed, and Scifinder. Catalpol exhibits anti-diabetic, cardiovascular protective, neuroprotective, anticancer, hepatoprotective, anti-inflammatory, and anti-oxidant effects in experimental studies. Anti-inflammatory and antioxidant properties are mostly related for its biological effect. However, some specific mechanisms are also elucidated. Elevated serotonin and BDNF level by catalpol significantly protect against depression and neurodegeneration. Catalpol demonstrated an increased mitochondrial biogenesis and activation of PI3K/Akt pathway for insulin sensitizing effect. Further, its cardiovascular protective effect was linked to PI3K/Akt, apelin/APJ and Jak-Stat pathway. Catalpol produced a significant reduction in cell proliferation and an increase in apoptosis in different cancer conditions. Overall, catalpol demonstrated multiple biological effects due to its numerous mechanisms including anti-inflammatory and antioxidant effects.

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Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 99%

Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 99%

Section: Effects Of Catalpol In Inflammatory and Oxidative Stress Conmentioning

confidence: 99%

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Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

et al. 2019

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“…In agreement with our findings Ma et al [34], Wu et al [22] and Malmström et al [35] who found significantly higher peripheral eosinophil counts in asthmatic group. Also, Chen et al [27] reported that there were statistically significant increase in the numbers of total leukocytes, lymphocytes, monocytes, eosinophils and basophils in the asthmatic group in comparison to control one.…”

Section: Discussionmentioning

confidence: 94%

“…IgE binds to the high-affinity IgE receptor FcεRI on mast cells and basophils, and antigen cross linking of IgE leads to degranulation and release of inflammatory mediators, including histamine, prostaglandins, and pro-inflammatory cytokines (IL-4, IL-5, IL-13). In the lower airways, this activity may result in eosinophilia, increased mucus production, and enhanced smooth muscle contractility [27].…”

Section: Discussionmentioning

confidence: 99%

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

El-Gohary¹,

Wagih²,

Hamouda³

et al. 2018

Biochem Mol biol J

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Background: Bronchial asthma is a common disease with multiple determinants that include genetic variation. Signal transducer and activator of transcription 6 (STAT6) is a central molecule in the signal transduction pathway used by interleukin-4 (IL-4) in immunoglobulin E (IgE) isotype switching. Study Objective was to investigate whether single nucleotide polymorphism (SNP) in STAT6 is associated with atopic asthma susceptibility in Egyptian children and to correlate the effect of STAT6 gene polymorphism on IL-4 and total IgE levels.

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Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases

Liu

et al. 2023

Drug Development Research

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Catalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted from the rhizome of the traditional medicinal herb rehmanniae. It has various biological activities such as anti‐inflammatory, antioxidant, and antitumor. The anti‐inflammatory effects of catalpol have been demonstrated in a variety of diseases, such as neurological diseases, atherosclerosis, renal diseases, respiratory diseases, digestive diseases, bone and joint diseases, eye diseases, and periodontitis. The purpose of this review is to summarize the existing literature on the anti‐inflammatory effects of catalpol in a variety of inflammatory diseases over the last decade and to focus on the anti‐inflammatory mechanisms of catalpol.

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Catalpol alleviates ovalbumin-induced asthma in mice: Reduced eosinophil infiltration in the lung

Cited by 31 publications

References 35 publications

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases

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