Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA

Park, Sook‐Young; Cho, Seong‐Jun; Kwon, Hak-chul; Lee, Kang-Ro; Rhee, Dong‐Kwon; Pyo, Suhkneung

doi:10.1016/j.canlet.2004.10.009

Cited by 137 publications

(83 citation statements)

References 23 publications

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“…MAPKs are comprised of the three parallel kinase modules, including p38-MAPK, ERK and JNK, especially the MAPK/ERK signaling pathway involved in cell survival and proliferation. Some active components from garlic have anti-cancer effects through the ERK1/2 and p38-MAPK signaling pathways (20,39,40). In the present study, the level of ERK phosphorylation was increased, and allicin-induced apoptosis was prevented by a pre-treatment with U0126, an ERK inhibitor (Fig.…”

Section: Discussionsupporting

confidence: 57%

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Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

et al. 2012

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Abstract. Allicin, the main flavor compound in garlic, has anti-carcinogenic activities in a range of cancer cells, however, the underlying molecular mechanisms are not completely understood. This study examined the effect of allicin on the cell viability of U87MG human glioma cells along with its molecular mechanisms of induction of cell death. Apoptosis was determined by TUNEL and Hoechst 33258 staining as well as by western blot analysis. Allicin inhibited the cell viability of U87MG human glioma cells in a dose-and time-dependent manner. Allicin-induced inhibition of cell viability was due to apoptosis of cells. The mechanisms of apoptosis were found to involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ ERK signaling pathway and antioxidant enzyme systems. These results suggest that allicin can serve as a novel chemotherapeutic candidate for the treatment of glioblastoma multiforme.

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Section: Discussionsupporting

confidence: 57%

“…Allicin-induced apoptosis was reported to be regulated through the caspase-dependent or -independent pathway (20,21). Fig.…”

Section: Allicin-induced Apoptosis Is Not Regulated By the Caspase Camentioning

confidence: 99%

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

et al. 2012

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“…Caspase-8 and -9 are self-activating initiators of apoptosis, whereas caspase-3 and -6 are believed to be executors of apoptosis through the decomposition of cellular proteins. Caspase-3 is present in many cells and induces apoptosis via different mechanisms (Park et al, 2005). In this study, caspase-3 was activated by treating the cells with sodium acetate for 6h; caspase-3 was significantly activated in the presence of 50 mM sodium acetate.…”

Section: Discussionmentioning

confidence: 69%

Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line

Yuan

Zhang

Jin³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The objective of this study was to investigate the effect of sodium acetate on the viability of the human gastric adenocarcinoma (AGS) epithelial cell line. AGS cells were exposed to a range of concentrations of sodium acetate for different periods of time, and the sodium acetate-induced cytotoxic effects, including cell viability, DNA fragmentation, apoptotic gene expression, and caspase activity, were assessed. The changes in these phenotypes were quantified by performing a lactate dehydrogenase cell viability assay, annexin V staining, terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL), and several caspase activity assays. In vitro studies demonstrated that the cytotoxicity of sodium acetate on the AGS cell line were dose-and time-dependent manners. No differences 2 Y. Xia et al. Genetics and Molecular Research 15 (4): gmr.15048375 were found between the negative control and sodium acetate-treated cells stained with annexin V and subjected to the TUNEL assay. However, caspase-3 activity was increased in AGS cells exposed to sodium acetate. Overall, it was concluded that sodium acetate exerted an apoptotic effect in AGS cells via a caspase-dependent apoptotic pathway.

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“…The antimicrobial [8,9], antitumor [10][11][12], antifungal [13], and antigenotoxic [14], activities of allicin have been reported. Meanwhile, various researches have indicated that garlic and allicin have inhibitory immunomodulatory action [15], they modulate immune responses, enhance humoral immunity and minimize immunological stress, and thus affect growth performance most positively [15].…”

Section: Introductionmentioning

confidence: 99%

Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

Osman

Adnan

Bakar

et al. 2012

pjp

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The research purpose was to experimentally investigate the effect of allicin administration on the levels of main type 1 diabetes (IDDM) autoantibodies which are antiislet cell antibodies (ICA) with an attempt to find a relation between this immunological effect and histological and/or biochemical findings. We have evaluated, with the help of ELISA kits, the levels of ICA and serum insulin in male Sprague-Dawley rats with Streptozotocin-induced IDDM in addition to pancreatic histological findings. The four groups (6 rats each) under study received or not different intraperitoneal doses of allicin for a period of 30 days. Daily intraperitoneal administration of allicin (either at as low dose of 8 mg/kg or high dose of 16 mg/kg) for up to 30 days to type 1 diabetic rats effectively reduces levels of anti-islet cell antibodies and in addition, reduced the level of insulin due to damaged Langerhans islet cell was significantly increased in the serum due to a repairing tissue process in pancreatic tissues. These experimental results suggest that allicin treatment has a therapeutic protective effect against autoimmune reactions occurring in IDDM. The data may provide new strategies for using allicin to be recommended as an excellent candidate in the clinical management, control, and prevention of IDDM.

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Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA

Cited by 137 publications

References 23 publications

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

Apoptotic effect of sodium acetate on a human gastric adenocarcinoma epithelial cell line

Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats

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