Case report: Catheter related blood stream infection caused by Candida vulturna

Candida vulturna Fungemia in an Infant With Congenital Megacolon from the Philippines

“…Initial drug of choice for the treatment of infection caused by CHSC or closely related species would be echinocandins because CHSC isolates often have high MICs for fluconazole and AMB [ 6 , 7 ]. Although CLSI clinical breakpoints are not available for this species, the isolates in this study had relatively low MICs against fluconazole (4 μg/mL), in agreement with previous findings [ 2 , 3 ], and the patient improved after fluconazole therapy.…”

“…vulnera [ 1 , 2 ]. Since C. vulturna was first detected in 2016 on an unspecified flower in the Philippines and in the blood of a patient who died of aspiration pneumonia in Malaysia [ 1 ], the organism has been isolated from cultures of blood or other clinical specimens, mostly in Southeast Asia and South America [ 2 - 4 ]. However, no detailed clinical data have been reported, except for one case of catheter-related fungemia in an elderly hospitalized patient [ 3 ].…”

“…As C. vulturna has been newly isolated/defined, it is not included in the databases of commercial identification systems and therefore is likely to be misidentified as a member of the known CHSC or closely related species, such as Candida auris and C. pseudohaemulonii [ 3 - 5 ]. Failed identification of C. vulturna using CHROMagar Candida has been reported [ 4 ].…”

Candida haemulonii Complex and Candida auris: Biology, Virulence Factors, Immune Response, and Multidrug Resistance

“…However, it has also been found in human bloodstream infections. [21][22][23] The occurrence of invasive candidiasis by this fungus makes it an emerging and opportunistic pathogen of clinical importance. Furthermore, it has been shown that some C. vulturna isolates are susceptible to echinocandins and azoles but resistant to amphotericin B.…”

“…Furthermore, it has been shown that some C. vulturna isolates are susceptible to echinocandins and azoles but resistant to amphotericin B. 22,23 The emergence of C. auris and the C. haemulonii complex as causative agents of candidiasis has attracted attention in recent years and exposed the need to increase our knowledge on aspected related to their biology, pathogenesis, interaction with the host, and the correct identification of these organisms. 20%.…”