Carvacrol (Origanum vulgare): Therapeutic Properties and Molecular Mechanisms

Mondal, Arijit; Bose, Sankhadip; Mazumder, Kamalika; Khanra, Ritu

doi:10.1007/978-3-030-54027-2_13

Cited by 5 publications

(2 citation statements)

References 90 publications

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“…Another natural product is carvacrol (CAR), the phenolic monoterpenoid found in essential oils of oregano ( Origanum vulgare ), thyme ( Thymus vulgaris ), pepperwort ( Lepidium flavum ), wild bergamot ( Citrus aurantium bergamia ), and other plants (Sharifi-Rad et al 2018 ). The high antioxidant activity of CAR is due to the hydroxyl group (OH), linked to the aromatic ring (Mondal et al 2021 ). The present experiment aims to assist the ani-aging protective effect of EU and CAR in experimentally induced aging in rats’ brains by d -gal.…”

Section: Introductionmentioning

confidence: 99%

Eugenol and carvacrol attenuate brain d-galactose-induced aging-related oxidative alterations in rats

El‐Far

Mohamed

Elsabagh

et al. 2022

Environ Sci Pollut Res

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Aging represents the accumulation of progressive changes in a human being over time and can cover physical, psychological, and social changes. It is an oxidative stress-associated process that progresses with age. The antioxidant activity of either eugenol (EU) or carvacrol (CAR) for aging in rats induced by d-gal for 42 days was investigated in the current study using 10 and 20 mg of EU/kg/day/orally, while CAR was supplemented by 40 and 80 mg /kg/day/orally. Biochemical, mRNA expression, and histopathological assessments of brain samples evaluated the oxidative alterations induced by d-gal and the protective role of EU and CAR. Results showed that d-gal was causing oxidative alternation of the brain that was recognized via upregulation of p53 and p21 mRNA expression levels, as aging markers and Bax mRNA expression level, as an apoptotic marker. Also, the results observed alterations in the levels of biochemical markers as creatine phosphokinase (CPK) and triacylglycerol (TAG), besides, enhancement of brain antioxidant capacity. Finally, these results compared with the groups treated with EU and CAR to observe that the EU and CAR potentially attenuate these aging-related oxidative alterations in a dose-dependent manner. Finally, we can conclude that EU and CAR supplementations are considered promising natural protective compounds that could delay aging and maintain health.

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Section: Introductionmentioning

confidence: 99%

Eugenol and carvacrol attenuate brain d-galactose-induced aging-related oxidative alterations in rats

El‐Far

Mohamed

Elsabagh

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…39 It is widely used in different biological applications to prevent the proliferation of chemotherapy-resistant cells such as human ovarian adenocarcinoma cells and tumor cells. 40,41 Compared to single drug-loaded nanoparticles, human serum albumin particles, when loaded with carvacrol and a chemotherapy agent, yield better activity in treating gastric cancer in vitro. 42 It was found to induce cell death by directly activating the mitochondrial pathway.…”

Section: Monoterpenesmentioning

confidence: 99%