Carvacrol-loaded liposome suspension: optimization, characterization and incorporation into poly(vinyl alcohol) films

Tavares, Adassa Gama; Andrade, João Sousa; Silva, Rafael Resende Assis; Marques, Clara Suprani; Silva, José Osvaldo Ramos da; Vanetti, Maria Cristina Dantas; Melo, Nathália Ramos de; Soares, Nilda de Fátima Ferreira

doi:10.1039/d1fo00479d

Cited by 18 publications

(4 citation statements)

References 36 publications

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“…Furthermore, carvacrol at high concentrations may be toxic to many cells [ 11 ]. Thus, to enhance carvacrol bioavailability and stability, while at the same time limiting potential negative side-effects, different nano-formulations have been proposed for its delivery to be applied as food preservative [ 12 , 13 , 14 ] or to contrast bacterial strains [ 15 , 16 ]. Chitosan (Cs), a polymer obtained for deacetylation of the natural compound chitin, is greatly consolidated in nano- and micro-delivery applications, due to its characteristics of biocompatibility, biodegradability, low toxicity, and high hydrophilicity [ 17 , 18 ], and because of the relative ease in preparing nano or microparticles [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Carvacrol Loaded Chitosan Nanoparticles

Vitali¹,

Stringaro

Colone

et al. 2021

Antibiotics

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The increased prevalence and incidence of fungal infections, of which Candida albicans represents one of the most life-threatening organisms, is prompting the scientific community to develop novel antifungal molecules. Many essential oils components are attracting attention for their interesting antifungal activities. Given the chemical and physical characteristics of these compounds, the use of appropriate nanodelivery systems is becoming increasingly widespread. In this study, chitosan nanoparticles were prepared using an ionic gelation procedure and loaded with the phenolic monoterpene carvacrol. After a bioassay guided optimization, the best nanoparticle formulation was structurally characterized by means of different spectroscopic (UV, FTIR and DLS) and microscopy techniques (SEM) and described for their functional features (encapsulation efficiency, loading capacity and release kinetics). The antifungal activity of this formulation was assayed with different Candida spp., both in planktonic and biofilm forms. From these studies, it emerged that the carvacrol loaded nanoparticles were particularly active against planktonic forms and that the antibiofilm activity was highly dependent on the species tested, with the C. tropicalis and C. krusei strains resulting as the most susceptible.

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Section: Introductionmentioning

confidence: 99%

Antifungal Carvacrol Loaded Chitosan Nanoparticles

Vitali¹,

Stringaro

Colone

et al. 2021

Antibiotics

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“…Obtained liposomes were stable after long-term storage at 4 °C and an exhibited EE >60%. Tavares et al 92 formulated carvacrolloaded liposome suspension. Liposomes with an EE of 60% with 4 mg/mL carvacrol were found to be the most optimum for encapsulation application.…”

Section: Different Nanocarriers Employed For the Encapsulation Of Eosmentioning

confidence: 99%

Recent Development in Essential Oil-Based Nanocarriers for Eco-Friendly and Sustainable Agri-Food Applications: A Review

Kumar

Kanwar

Mehta

2022

ACS Agric. Sci. Technol.

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The demand for greener agrochemicals and food preservatives has risen significantly during the last few decades to combat the harmful effects of conventional agrochemicals on the environment and human health. Essential oils (EOs) with their natural origin and potent antimicrobial, antibacterial, antifungal, and insect-repellant activities have appeared as a greener and biocompatible alternatives for sustainable agri-food applications. Their use in free form is limited, due to high volatile nature, poor aqueous solubility and therefore, various nanocarriers have been successfully employed for the encapsulation of EOs. These nanocarriers not only prevent the EOs from harsh external environmental conditions but also enhance their efficacy in agri-food applications. Here, we review the different nanocarriers such as emulsions, lipid nanoparticles, biopolymeric nanoparticles, clay-based nanoparticles, and inclusion complexes, which are being extensively used to encapsulate EOs with their respective applications in the food and agriculture sector. Some major recent research attempts being made by researchers to formulate different essential oilloaded nanocarriers and their potential activity in agri-food-based applications have been discussed.

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“…Liposomes are widely acknowledged for their efficacy as a delivery system (Andresen et al ., 2005), proficient in encapsulating a wide array of functional ingredients (Vikbjerg et al ., 2007; Tan et al ., 2013; Pan et al ., 2018; Gonzalez‐Ortega et al ., 2021; Sepulveda et al ., 2021; Tavares et al ., 2021; Chen & Fang, 2022; Lv et al ., 2023), ranging from hydrophilic to lipophilic components (Esposto et al ., 2021). They boast several advantages, including biocompatibility, biodegradability, amphiphilicity, non‐toxicity and non‐immunogenicity (Jesorka & Orwar, 2008; Khezri et al ., 2018; Feng et al ., 2020).…”

Section: Introductionmentioning

confidence: 99%

Modification of liposomes: preparation, purpose, methods and the application in food

Liu,

Zan,

et al. 2024

Int J of Food Sci Tech

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SummaryThe use of liposomes as an effective delivery system has been well documented. This system offers protection to functional components from various environmental factors such as light, oxygen, temperature and pH. However, liposomes also present certain limitations, including poor targeting, instability, short in vivo circulation time and low utilisation of encapsulated substances. These drawbacks can be addressed through the modification of liposomes. This review article examines the preparation of modified liposomes using methods such as the thin‐film method, reverse evaporation method and injection method. The purpose of liposome modification and its application in food are discussed, with a focus on enhancing targeting, prolonging in vivo circulation time, improving stability and ensuring the stability of encapsulated substances during storage. Additionally, the article explores modification methods such as polyethylene glycol modification, peptide and protein modification and polysaccharide modification. This comprehensive review aims to contribute to a better understanding of liposome modification and provide valuable references for the development of novel modified liposomes.

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Carvacrol-loaded liposome suspension: optimization, characterization and incorporation into poly(vinyl alcohol) films

Abstract: The purpose of this study was to encapsulate carvacrol in liposomes in order to promote its application in food preservation. Response surface methodology was used to evaluate the effect of...

Cited by 18 publications

References 36 publications

Antifungal Carvacrol Loaded Chitosan Nanoparticles

Antifungal Carvacrol Loaded Chitosan Nanoparticles

Recent Development in Essential Oil-Based Nanocarriers for Eco-Friendly and Sustainable Agri-Food Applications: A Review

Modification of liposomes: preparation, purpose, methods and the application in food

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