Cartilage Tissue Engineering Using Electrospun PCL Nanofiber Meshes and MSCs

Silva, Marta Alves da; Martins, Albino; Costa-Pinto, Ana Rita; Costa, Pedro da; Faria, Susana; Gomes, Manuela E.; Reis, Rui L.; Neves, Nuno M.

doi:10.1021/bm100476r

Cited by 153 publications

(81 citation statements)

References 45 publications

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“…By contrast, melt electrospinning generates a liquid polymer by heating the material until it liquifies [53]. Both electrospinning techniques have been successfully applied to the field of tissue engineering as way to produce a variety of tissue types [65][66][67][68].…”

Section: Fabrication Of Fibrous Scaffolds Using Solution and Melt Elementioning

confidence: 99%

Commercializing Electrospun Scaffolds For Pluripotent Stem Cell-Based Tissue Engineering Applications

Mohtaram¹,

Karamzadeh

Shafieyan³

et al. 2017

Electrospinning

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Tissue engineering, the process of combining bioactive scaffolds often with cells to produce replacements for damaged organs, represents an enormous market opportunity. This review critically evaluates the commercialization potential of electrospun scaffolds for applications in stem cell biology, including tissue engineering. First, it provides an overview of pluripotent stem cells (PSCs) and their defining properties, pluripotency and the ability to self-renew. These cells serve as an important tool for engineering tissues, including for clinical applications. Next, we review the technique of electrospinning and its promise for fabricating cell culture substrates and scaffolds for directing tissue formation from stem cells and compare these scaffolds to existing technologies, such as hydrogels. We address the associated market for electrospun scaffolds for PSCs and its potential for growth along with highlighting the importance of 3D cell culture substrates for PSCs by analyzing the net capital invested in this market and the associated growth rate. This review finishes by detailing the current state of commercializing electrospun scaffolds along with pathways for translating these scaffolds from research laboratories into successful start-up companies and the associated challenges with this process.

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Section: Fabrication Of Fibrous Scaffolds Using Solution and Melt Elementioning

confidence: 99%

Commercializing Electrospun Scaffolds For Pluripotent Stem Cell-Based Tissue Engineering Applications

Mohtaram¹,

Karamzadeh

Shafieyan³

et al. 2017

Electrospinning

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“…Reprinted with permission from [15], Copyright could also be a reason for regeneration issues [12]. Da Silva et al [116] used PCL nanofiber meshes to culture mesenchymal stem cells in a multichamber flow perfusion bioreactor. They showed that there was an increased rate of differentiation of MSCs into chondroitic cells.…”

Section: Musculoskeletal Tissuementioning

confidence: 99%

Multifunctional Nanofibers towards Active Biomedical Therapeutics

et al. 2015

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One-dimensional (1-D) nanostructures have attracted enormous research interest due to their unique physicochemical properties and wide application potential. These 1-D nanofibers are being increasingly applied to biomedical fields owing to their high surface area-to-volume ratio, high porosity, and the ease of tuning their structures, functionalities, and properties. Many biomedical nanofiber reviews have focused on tissue engineering and drug delivery applications but have very rarely discussed their use as wound dressings. However, nanofibers have enormous potential as wound dressings and other clinical applications that could have wide impacts on the treatment of wounds. Herein, the authors review the main fabrication methods of nanofibers as well as requirements, strategies, and recent applications of nanofibers, and provide perspectives of the challenges and opportunities that face multifunctional nanofibers for active therapeutic applications.

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“…Poly(ε-caprolactone) (PCL) is an FDA approved biodegradable polymer used for a wide range of biomaterial applications [24,27,[34][35][36]. Moreover, it is easily electrospun into nanofiber using a range of solvents and preparation parameters [34][35][36][37][38][39][40]. Electrospinning has a wide range of uses due to the customization available.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

Garrett

Niiyama

Kotsuchibashi

et al. 2015

Fibers

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Abstract:In this paper we investigate a potential new treatment option for basal cell carcinoma using electrospun polymer nanofibers. Poly(ε-caprolactone) fibers incorporated with the anti-cancer drug imiquimod were successfully produced for the first time. These fibers were characterized and their diffusion release profile tested in vitro. A range of different electrospinning parameters were investigated in order to determine the most effective approach in optimizing the fibers for future in vivo testing. Characterization showed stable and homogeneous distribution of imiquimod. Although the drug was released faster than what would be needed to replicate the current treatment model, this system would ideally allow for a treatment option which reduces side effects and is more convenient for the patient than the current topical treatment.

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Cartilage Tissue Engineering Using Electrospun PCL Nanofiber Meshes and MSCs

Cited by 153 publications

References 45 publications

Commercializing Electrospun Scaffolds For Pluripotent Stem Cell-Based Tissue Engineering Applications

Commercializing Electrospun Scaffolds For Pluripotent Stem Cell-Based Tissue Engineering Applications

Multifunctional Nanofibers towards Active Biomedical Therapeutics

Biodegradable Nanofiber for Delivery of Immunomodulating Agent in the Treatment of Basal Cell Carcinoma

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