Carotid Intima-Media Thickness as a Predictor of Response to Cholinesterase Inhibitors in Alzheimerʼs Disease

Modrego, Pedro J.; Ríos, C; Trullen, J.M. Pérez; García-Gomara, María José; Errea, José M.

doi:10.2165/00023210-200923030-00006

Cited by 9 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IMT-dependent regional cerebral blood flow (rCBF) differences have been identified 42 , and neuronal viability suffers with presence of subclinical atherosclerosis 43 . Carotid IMT has also been increasingly linked with future dementia, both due to Alzheimer’s disease and vascular causes 13, 44, 45 , and IMT has been shown to predict response to cholinesterase inhibitors in Alzheimer’s disease 46 . While there is no shortage of explanatory hypotheses, the specific interrelations and pathways are yet to be understood, especially in relation to demographic subgroups.…”

Section: Discussionmentioning

confidence: 99%

Subclinical carotid atherosclerosis and neurocognitive function in an urban population

et al. 2016

View full text Add to dashboard Cite

Background and aims Examine age, sex, race, and socioeconomic status as modifiers of the association between carotid intimal medial thickness (IMT) and neurocognitive performance in a socioeconomically diverse, biracial, urban, adult population. Methods Participants were 1,712 community-dwelling adults (45% men, 56% African-American, 38% below poverty threshold, aged 30-64 years) enrolled in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Participants underwent initial carotid ultrasonography followed by cognitive testing on up to two occasions over 4 years. Mixed-effects regression analyses were adjusted for demographic, behavioral, and biomedical covariates. Results Significant cross-sectional IMT × race × poverty interactions were identified for measures of delayed recall memory, auditory-verbal attention, and working memory. An IMT × race interaction also appeared for auditory-verbal learning. Higher IMT was generally associated with worse cognitive performance, but the disadvantage was most pronounced among those with higher socioeconomic status and white participants. No longitudinal associations were identified. Conclusions Carotid IMT-cognition associations differed as a function of race and socioeconomic status and were most compelling for measures of attention, executive function, and memory. These findings highlight the possibility that subclinical atherosclerosis may be differentially informative as a predictor of cognitive performance among varied demographic subgroups.

show abstract

Section: Discussionmentioning

confidence: 99%

Subclinical carotid atherosclerosis and neurocognitive function in an urban population

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Abnormal values of IMT also significantly increase the risk of conversion from amnestic MCI to AD (Viticchi et al, 2012). In a longitudinal study involving a 6-month galantamine treatment of AD, the patients with lower values of IMT at baseline had better response to treatment (Modrego et al, 2009), which suggests that AD patients with lower cerebrovascular burden have slower progression of disease. Details of ultrasound projects focused on IMT and carotid atherosclerosis in AD are listed in Table 1.…”

Section: Extracranial Ultrasound In Admentioning

confidence: 99%

Neurosonological Examination: A Non-Invasive Approach for the Detection of Cerebrovascular Impairment in AD

Urbanová

Tomek

Mikulík

et al. 2014

Front. Behav. Neurosci.

View full text Add to dashboard Cite

There has been a growing interest in vascular impairment associated with Alzheimer's disease (AD). This interest was stimulated by the findings of higher incidence of vascular risk factors in AD. Signs of vascular impairment were investigated notably in the field of imaging methods. Our aim was to explore ultrasonographic studies of extra-and intracranial vessels in patients with AD and mild cognitive impairment (MCI) and define implications for diagnosis, treatment, and prevention of the disease. The most frequently studied parameters with extracranial ultrasound are intima-media thickness in common carotid artery, carotid atherosclerosis, and total cerebral blood flow. The transcranial ultrasound concentrates mostly on flow velocities, pulsatility indices, cerebrovascular reserve capacity, and cerebral microembolization. Studies suggest that there is morphological and functional impairment of cerebral circulation in AD compared to healthy subjects. Ultrasound as a non-invasive method could be potentially useful in identifying individuals in a higher risk of progression of cognitive decline.

show abstract

“…Modrego and colleagues [1] write: ''IMT is widely recognized as a good marker of atherosclerosis in general and could be a useful surrogate marker of cerebrovascular burden in the brain of patients with Alzheimer's disease y''. It has to be specified that the consensus as to whether to consider increased C-IMT as a marker of subclinical atherosclerosis is still contingent within the scientific community and subject to debate.…”

Section: C-imt As a Surrogate Marker For Atherosclerosismentioning

confidence: 99%

“…Modrego and colleagues [1] write: ''A 12-year study of a population-based cohort of 91 elderly women showed that an increased IMT of the carotid bifurcation was an independent predictor of poor memory and reduced cognitive speed. [7] Likewise, in a cohort of 400 men, increased IMT of the carotid artery was associated with poorer performance on memory tests.…”

Section: C-imt As a Surrogate Marker For Atherosclerosismentioning

confidence: 99%

“…In their open-label trial published in a previous issue of CNS Drugs, Modrego and colleagues [1] investigate whether carotid intima-media thickness (C-IMT) predicts the response to cholinesterase inhibitors in Alzheimer's disease. A series of 54 consecutively enrolled patients with mild to moderate Alzheimer's disease were assessed with a battery of several neuropsychological tests and investigated with brain MRI and carotid artery ultrasonography for the measurement of intimamedia thickness (IMT).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Carotid Intima-Media Thickness

Saleh¹

2010

CNS Drugs

View full text Add to dashboard Cite

Background-Cardiovascular disease in women often develops without conventional risk factors. Prenatal loss is a common pregnancy outcome that may result in physiological changes can increase the potential future risk of cardiovascular disease. Insufficient information exists regarding the impact of pregnancy loss on early markers of cardiovascular disease risk. Methods and Results-Cross-sectional analysis of 1767 disease-free women from the MTC (Mexican Teachers' Cohort) who had been pregnant was used to evaluate the relationship between pregnancy loss and carotid intima-media thickness (IMT). Participants responded to a questionnaire regarding their reproductive history, risk factors, and medical conditions. We defined pregnancy loss as history of miscarriage and/or stillbirth. Trained neurologists measured IMT using ultrasound. We log-transformed IMT and defined subclinical carotid atherosclerosis (SCA) as IMT ≥0.8 mm and/or plaque. We used multivariable linear and logistic regression models to assess the relation of pregnancy loss, IMT, and SCA. The mean age of participants was 49.8AE5.1 years. The prevalence of pregnancy loss was 22%, and we observed SCA in 23% of participants. Comparing participants who reported a pregnancy loss and those who did not, the multivariable-adjusted odds ratio for SCA was 1.52 (95% confidence interval, 1.12-2.06). Women who experienced a stillbirth had 2.32 higher odds (95% confidence interval, 1.03-5.21) of SCA than those who did not. Mean IMT appeared to be higher in women who reported a pregnancy loss relative to those who did not; nevertheless, this was not statistically significant. Conclusions-Pregnancy loss could be linked to cardiovascular disease later in life. The key findings of our study await confirmation and further investigation of the potential underlying mechanisms for this association is required. (J Am Heart Assoc.

show abstract

Carotid Intima-Media Thickness as a Predictor of Response to Cholinesterase Inhibitors in Alzheimerʼs Disease

Abstract: Although the magnitude of effect was moderate, carotid IMT could be a significant predictor of clinical response to cholinesterase inhibitors in patients with Alzheimer's disease.

Cited by 9 publications

References 35 publications

Subclinical carotid atherosclerosis and neurocognitive function in an urban population

Subclinical carotid atherosclerosis and neurocognitive function in an urban population

Neurosonological Examination: A Non-Invasive Approach for the Detection of Cerebrovascular Impairment in AD

Carotid Intima-Media Thickness

Contact Info

Product

Resources

About