Subclinical carotid atherosclerosis and neurocognitive function in an urban population

Wendell, Carrington R.; Waldstein, Shari R.; Evans, Michele K.; Zonderman, Alan B.

doi:10.1016/j.atherosclerosis.2016.04.009

Cited by 16 publications

(17 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, subclinical atherosclerosis was not associated with NCI; however, participants with subclinical atherosclerosis showed significantly lower capacity for DR. This study and others 35,36 suggest that CMI thickness could be associated with neurocognitive impairment in PLWHIV.…”

Section: Discussionsupporting

confidence: 64%

Neurocognitive Impairment in Well-Controlled HIV-Infected Patients: A Cross-Sectional Study

Portilla

Reus

León

et al. 2019

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

Background. The reported prevalence of HIV-associated neurocognitive disorders in HIVpeople depends on the population studied and the methodology used. We analyze the prevalence of neurocognitive impairment (NCI) and associated factors in patients on successful antiretroviral therapy (ART), without comorbidities. Matherial and methods. Cross-sectional observational study in HIV-subjects, ≥18 yearsold, on stable ART and HIV viral load <50copies/mL. Patients with medical or psychiatric comorbidities and substance abuse were excluded. NCI was diagnosed using Frascati criteria, examining seven neurocognitive domains. We analyzed the association between NCI and: HIV-related clinical variables, carotid intima media thickness, bacterial traslocation, and plasma inflammatory biomarkers (soluble CD14, Interleukin-6 [IL-6], and tumor necrosis factor-α). The prevalence of NCI was calculated with a 95%CI. We fitted a logistic regression model to assess the strength of the associations. Results. Eighty-four patients were included with an observed NCI prevalence of 29.8% (95%CI: 21.0-40.2): 19% had asymptomatic neurocognitive impairment; 8.3%, mild neurocognitive disorder; 2.4%, HIV-associated dementia. Delayed recall was the most commonly affected neurocognitive domain (27.4%). People diagnosed at least 10 years ago (OR:6.5, 95%CI: 1.6-21.7) and those with IL-6 levels above 1.8 pg/mL (OR:6.0, 95%CI 1.1-31.3.3) showed higher odds of NCI in adjusted analyses. Participants with carotid plaques had lower scores for delayed recall: −0.9±1.1 versus −0.2±1.1 (p=0.04). Conclusions. Prevalence of NCI is high in otherwise healthy adults with HIV-infection. In this population, more than 10 years since HIV diagnosis and high IL-6 levels are associated with NCI. Delayed recall neurocognitive domain is worse in patients with subclinical atherosclerosis.

show abstract

Section: Discussionsupporting

confidence: 64%

Neurocognitive Impairment in Well-Controlled HIV-Infected Patients: A Cross-Sectional Study

Portilla

Reus

León

et al. 2019

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

show abstract

“…The literature search retrieved 6879 studies, of which 19 cross‐sectional and 15 longitudinal studies were included in this systematic review and meta‐analysis 15 , 22 , 23 , 24 , 25 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 (Figure S1 ). The studies included a total of 50 779 participants aged 45.3 to 78.0 years.…”

Section: Resultsmentioning

confidence: 99%

Intima Media Thickness and Cognitive Function Among Adults: Meta‐Analysis of Observational and Longitudinal Studies

Álvarez‐Bueno

Cavero‐Redondo

Bruno

et al. 2022

JAHA

View full text Add to dashboard Cite

Background Carotid structural changes measured by intima media thickness (IMT) have been related to cognitive complaints during aging. Therefore, the aims of this meta‐analysis were (1) to elucidate the relationship between vascular status, measured as IMT, and cognitive domains distinguishing between global cognition, executive functions, memory and attention; and (2) to explore whether demographic (ie, age and sex), clinical (ie, body mass index and IMT baseline values), and procedure characteristics influence this association. Methods and Results We performed a systematic review of MEDLINE (via PubMed), Scopus, and Web of Science databases from their inception to June 2021. Studies meeting the following inclusion criteria were included: (1) the participants were adults; (2) the exposure was carotid IMT; (3) the outcome was cognitive function, including global cognition, executive function, memory, and attention measured using standardized tests; and (4) the study design was cross‐sectional or longitudinal including unadjusted and adjusted analyses. A total of 19 cross‐sectional and 15 longitudinal studies were included and demographic (age and sex), clinical (body mass index and baseline IMT values), and procedure characteristics were analyzed as potential mediator or moderators of the association. Conclusions Our data support negative associations between IMT and cognitive function in cross‐sectional studies. The association between IMT and cognition lost significance in longitudinal studies and when controlling for covariates in cross‐sectional studies. Finally, the strength of these associations seems not to be modified by age, sex, body mass index, and baseline IMT values. This systematic review and meta‐analysis adds to the evidence supporting the use of IMT as a measure for identifying patients at risk of cognitive decline.

show abstract

“…Adjusting for cardiovascular and lifestyle variables resulted in a change in effect estimate and loss of significance. However, previous studies have shown that atherosclerosis is independently associated with reduced cognitive performance, but these studies have used other neuropsychological tests and different definitions of atherosclerosis, or have failed to perform multiple adjustments [11,15,20,21,35,36]. The heterogeneity in available data complicates comparison between studies.…”

Section: Discussionmentioning

confidence: 99%

Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study

Ihle‐Hansen

Vigen

Berge

et al. 2019

JAD

View full text Add to dashboard Cite

BACKGROUND: Studies on the relationship between carotid atherosclerosis and cognitive function in subjects from the general population are few and results have been inconsistent. OBJECTIVES:We aimed to investigate the association between carotid atherosclerotic burden and cognitive function in a cross-sectional analysis of a population-based cohort aged 63-65 years.. METHODS:All habitants born in 1950 from Akershus County, Norway were invited to participate.A linear regression model was used to assess the association between carotid atherosclerosis and cognitive function. We used carotid plaque score as a measure of carotid atherosclerotic burden and the Montreal Cognitive Assessment (MoCA) for global cognitive function. RESULTS:We analysed 3,413 individuals aged 63-65 with mean MoCA score 25.3±2.9 and 87% visible carotid plaques. We found a negative correlation between carotid plaque score and MoCA score (r=-0.14, p<0.001), but this association was lost in multivariable analysis. In contrast, diameter or area of the thickest plaque was independently associated with MoCA score. Lower educational level, male sex, current smoking and diabetes were also associated with lower MoCA score in multivariable analysis. CONCLUSION:Carotid atherosclerotic burden was, unlike other measures of advanced carotid atherosclerosis, not independently associated with global cognitive function.

show abstract

Subclinical carotid atherosclerosis and neurocognitive function in an urban population

Cited by 16 publications

References 39 publications

Neurocognitive Impairment in Well-Controlled HIV-Infected Patients: A Cross-Sectional Study

Neurocognitive Impairment in Well-Controlled HIV-Infected Patients: A Cross-Sectional Study

Intima Media Thickness and Cognitive Function Among Adults: Meta‐Analysis of Observational and Longitudinal Studies

Carotid Atherosclerosis and Cognitive Function in a General Population Aged 63-65 Years: Data from the Akershus Cardiac Examination (ACE) 1950 Study

Contact Info

Product

Resources

About