Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis

Meyer, Michelle L.; Malek, Angela M.; Wild, Robert A.; Korytkowski, Mary T.; Talbott, Evelyn O.

doi:10.1093/humupd/dmr046

Cited by 136 publications

(99 citation statements)

References 73 publications

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“…42,44 As for the inflammatory molecules, data on the relationship between PCOS and carotid intima-media wall thickness (cIMT), a marker of preclinical atherosclerosis, are not conclusive. In a previous study, 25 in this same cohort of women, we have demonstrated that by adopting stricter diagnostic criteria and excluding major CV risk factors 25,45 no differences were evident in vascular parameters related to early atherosclerosis in women with PCOS. This was also shown by Kahal et al 46 by studying obese women with PCOS diagnosed by strict diagnostic criteria and matched not only for BMI but also for abdominal obesity, blood pressure, lipid profile and smoking history.…”

Section: Declaration Of Interestmentioning

confidence: 58%

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Barcellos¹,

Rocha²,

Hayashida³

et al. 2015

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obJectIve: the aim of this study was to evaluate the influence of polycystic ovary syndrome (pcos) and obesity on circulating markers of low-grade inflammation-tumor necrosis factoralpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (cv) risk factors (diabetes, dyslipidemia and arterial hypertension). desIGn: twenty-five young women with pcos and 23 eumenorrheic women without major cv risk factors and matched for body mass index (bmI) were studied. they were subdivided according to bmI and pcos status and comparisons were made between the pcos and control groups, regardless of bmI, and between the obese and Lean groups, regardless of the presence of PCOS. RESULTS: Levels of TNF-α, IL-6 and hsCRP were similar between the pcos group and the control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-α were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hscrp were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively). concLusIon: obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cv risk factors.

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Section: Declaration Of Interestmentioning

confidence: 58%

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Barcellos¹,

Rocha²,

Hayashida³

et al. 2015

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“…About 60%-70% of PCOS patients present central obesity that is well known to be associated with insulin resistance and increased risk of type 2 diabetes mellitus, hypertension, dyslipidemia, endothelial dysfunction and heart disease (25). In association with insulin resistance, obesity contributes to the 40% prevalence of the metabolic syndrome in PCOS (26)(27)(28)(29)(30)(31)(32)(33). Recent data have shown a complex correlation between insulin resistance and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid Concentration in Overweight and Obese Women with Polycystic Ovary Syndrome / Nivelul acidului uric la femeile supraponderale și obeze cu sindromul ovarelor polichistice

Leuștean¹,

Dimitriu²,

Fica³

et al. 2015

Romanian Review of Laboratory Medicine

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“…PCOS affects 6-15% of reproductive-age women (2,3). PCOS is often associated with obesity (4), increased oxidative stress (5), systemic chronic inflammation (6), elevated prevalences of metabolic syndrome and type 2 diabetes (7), and potentially increased risks of atherosclerosis and cardiovascular disease (8,9). The etiology of PCOS remains unclear, but studies have suggested that PCOS appears to have a complex, multifactorial etiology in which a variety of predisposing genes interact with environmental factors to produce the disease (10,11).…”

Section: Introductionmentioning

confidence: 99%

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Zhang

Liu

et al. 2015

European Journal of Endocrinology

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Objective: To study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the PON1 genetic polymorphisms in women with polycystic ovarian syndrome (PCOS). Design: A case-control study. Methods: A total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) respectively. A normalized lactonase activity (NLA) was estimated based on the ratio of TBBLase:DEPCyMCase activity. The PON1 genotypes, serum malondialdehyde (MDA) levels and total antioxidant capacity were analyzed. Results: The lactonase activities and levels of PON1 were higher in PCOS patients than in the control women. However, the NLA did not significantly differ between groups. The K108C/T variation of the PON1 gene showed decreased lactonase activities and levels of PON1 in a genotype-dependent manner (CCOCTOTT); the 192Q/R variation of the PON1 gene showed increased PON1 lactonase activities and NLA; and the 55L/M variation of the PON1 gene showed decreased lactonase activities and levels of PON1 but an increased NLA. A multivariable regression analysis showed that the K108C/T, 192Q/R, and 55L/M variations of the PON1 gene, serum apolipoprotein A1, and MDA levels were significant predictors of PON1 lactonase activity, PON1 level, and NLA. Conclusions: The serum lactonase activities and concentrations of PON1 are increased in PCOS patients. The increased oxidative stress and the K108C/T, 192Q/R, and 55L/M genetic polymorphisms of PON1 may be associated with these changes.

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Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis

Cited by 136 publications

References 73 publications

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Serum Uric Acid Concentration in Overweight and Obese Women with Polycystic Ovary Syndrome / Nivelul acidului uric la femeile supraponderale și obeze cu sindromul ovarelor polichistice

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

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