Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Barcellos, Cristiano Roberto Grimaldi; Rocha, Marco; Hayashida, Sylvia Asaka Yamashita; Dantas, Wagner Silva; Yance, Viviane Dos Reis Vieira; Marcondes, José Antônio Miguel

doi:10.14310/horm.2002.1584

Cited by 14 publications

(12 citation statements)

References 49 publications

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“…Circulating IL-6 was measured in 16 articles, of which five reported significantly higher levels in PCOS women compared to healthy controls (Table 3) [53,55,70,73,116]. The remaining 11 studies found no significant difference in circulating IL-6 between PCOS and non-PCOS women [45,[48][49][50]56,59,63,67,82,92,96].…”

Section: Il-6 Resultsmentioning

confidence: 99%

“…Of these, 45 studies provided data on other inflammatory markers such as IL-6, TNF-α, adiponectin, etc., as summarised in Table 2. Mean ± SD CRP values were not provided in 22 studies [42,46,60,62,63,65,66,68,72,73,78,82,83,92,93,99,108,110,112,118,119,121]. Authors of these articles were contacted to provide the missing data, but no response was received despite several reminders.…”

Section: Included Studiesmentioning

confidence: 99%

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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

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Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle–Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation.

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Section: Il-6 Resultsmentioning

confidence: 99%

Section: Included Studiesmentioning

confidence: 99%

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

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“…IL-6 and CRP were significantly higher in women with overweight/obesity than in normal-weight women (8.7 vs 2.0 pg/mL, P < 0.001, and 1.4 vs 0.2 ng/mL, P < 0.001). The authors concluded that obesity, but not PCOS itself, affects the levels of circulating markers of a chronic low-grade inflammation in young carriers of the syndrome without major CVD risk factors [183].…”

Section: Tumor Necrosis Factor α (Tnf-α) and Interleukin-6 (Il-6)mentioning

confidence: 99%

Clinical Impact of Insulin Resistance in Women with Polycystic Ovary Syndrome

Orbetzova¹

2020

Polycystic Ovarian Syndrome

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Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder characterized by multiple hormonal imbalances, reflecting on the clinical presentation. Among them, the insulin resistance (IR), defined as a metabolic state characterized by a decrease in cellular ability to respond to insulin signaling, is a key feature of PCOS independently of obesity. Thus, IR occurs in more than 70% of obese PCOS women and in 30-50% of lean ones. Compensatory high insulin levels are both a symptom and an underlying physiopathological driver of PCOS. Insulin appears to disrupt all components of the hypothalamic-pituitary-ovarian axis, and ovarian tissue IR results in impaired metabolic signaling but intact mitogenic and steroidogenic activity, favoring hyperandrogenemia. The latter is the main culprit of the clinical picture in PCOS. Testing for IR can be helpful to rule out other conditions that are commonly misdiagnosed as PCOS and to recommend an appropriate treatment for the different PCOS phenotypes.

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“…There is evidence that PCOS is also a proinflammatory disorder, characterized by the presence of chronic lowgrade inflammation and there is increased level of several inflammatory cytokines that are associated with insulin resistance (IR). Obesity and diabetes mellitus have also been found to be associated with the syndrome [12].…”

Section: Issn: 0067-2904mentioning

confidence: 99%

Serum level evaluation of interleukin-18 in obese women with polycystic ovary syndrome

Ibrahim

Al-saffar

2018

ijs

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This study is designed to measure the level of interleukin (IL) 18 in polycystic ovary women and its association with obesity. In this study, blood samples from 50 women with PCOS and 30 healthy control women were collected from AL-Yarmouk Teaching, Baghdad Teaching hospitals During January 2018-March 2018 for estimation of their serum level of IL18 by using enzyme-linked immunosorbent assay (ELISA) technique and evaluation serum levels of luteinizing hormone (LH), Follicle-stimulating hormone (FSH), Testosterone, prolactin (PRL) and Estradiol (E2) by using Electrochemiluminescence immunoassay (ECLIA). The results showed that there is a highly significant increase (P < 0.001) in serum level of IL18 in PCOS women than in healthy control group. As well as, the results of IL-18 value according to Body mass index (BMI) showed significant difference (P<0.05) between BMI and IL-18 level in all the PCOS patient subgroups (normal weight, overweight and obesity). Also, there was a significant increase in LH, FSH, PRL and T, and significant decrease in E2 was detected in PCOS patients.

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Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Cited by 14 publications

References 49 publications

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Clinical Impact of Insulin Resistance in Women with Polycystic Ovary Syndrome

Serum level evaluation of interleukin-18 in obese women with polycystic ovary syndrome

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