Carotid Artery Intima-Media Thickness, Carotid Plaque and Coronary Heart Disease and Stroke in Chinese

Chien, Kuo–Liong; Su, Ta‐Chen; Jeng, Jiann‐Shing; Hsu, Hsiu-Ching; Chang, Wei‐Tien; Chen, Ming-Fong; Lee, Yuan‐Teh; Hu, Frank B.

doi:10.1371/journal.pone.0003435

Cited by 65 publications

(63 citation statements)

References 56 publications

(66 reference statements)

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“…The normal human serum visfatin level is 15.8 ± 16.7 ng/mL. (16) CCA-IMT was determined using standard procedures, (17) with…”

Section: Methodsmentioning

confidence: 99%

Increased serum visfatin as a risk factor for atherosclerosis in patients with ischaemic cerebrovascular disease

Kong¹,

Xia²,

Liang³

et al. 2014

smedj

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RESULTSThe mean serum visfatin level of the patients in Group B was higher than that in Group A (75.5 ± 77.80 ng/mL vs.8.6 ± 4.69 ng/mL; p < 0.05) and the level was higher in patients from Group B2 than those from Group B1 (89.0 ± 80.68 ng/mL vs. 50.4 ± 72.44 ng/mL; p < 0.05). Multivariate regression analysis showed that CCA-IMT values were not significantly associated with visfatin levels. However, logistic regression analysis showed that serum visfatin was an independent risk factor for atherosclerosis (odds ratio 37.80; p = 0.004).CONCLUSION Serum visfatin may be an independent risk factor for cerebral infarction, as high serum visfatin levels are positively associated with the underlying pathogenic mechanisms of ischaemic cerebrovascular disease.

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“…The normal human serum visfatin level is 15.8 ± 16.7 ng/mL. (16) CCA-IMT was determined using standard procedures, (17) with…”

Section: Methodsmentioning

confidence: 99%

Increased serum visfatin as a risk factor for atherosclerosis in patients with ischaemic cerebrovascular disease

Kong¹,

Xia²,

Liang³

et al. 2014

smedj

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“…18,19,26 Participants with a baseline history of stroke events (nϭ89) were excluded from this study. Incident stroke cases were ascertained according to the following criteria: a sudden neurological symptom of vascular origin that lasted Ͼ24 hours with supporting evidence from the image study; fatal stroke cases were included.…”

Section: Follow-up Strategy and Outcome Ascertainmentmentioning

confidence: 99%

Constructing the Prediction Model for the Risk of Stroke in a Chinese Population

Chien

Hsu

et al. 2010

Stroke

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Background and Purpose-Prediction rules for the risk of stroke have been proposed. However, most studies were conducted with whites or for secondary prevention, and it is not clear whether these models apply to the Chinese population. The purpose of this study was to construct a simple points-based clinical model for predicting incident stroke among Chinese adults in Taiwan. Methods-We estimated the 10-year risk of stroke in a cohort study of middle-aged and elderly participants who were free from stroke at baseline. Multivariate Cox model-derived coefficients were used to construct the simple points-based clinical and biochemical model and the prediction measures using the area under the receive operating characteristic curve, net reclassification improvement, and integrated discrimination improvement statistics were applied. Results-Of the 3513 participants without stroke at baseline, 240 incident cases of stroke were documented for a median 15.9-year follow-up. Age (8 points), gender (1 point), systolic blood pressure (3 points), diastolic blood pressure (2 points), family history of stroke (1 point), atrial fibrillation (3 points), and diabetes (1 point) were found to significantly predict stroke events. The estimated area under the receive operating characteristic curve for this clinical points-based model was 0.772 (95% CI, 0.744 to 0.799). The discrimination ability of this clinical model was similar to the coefficients-based models and better than available stroke models. Conclusions-We

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“…In a communitybased cohort study in a Chinese population a significant association was found between carotid IMT and incidence of CHD and stroke in Chinese adults, but neither the AUC for CHD nor that for stroke significantly improved after IMT addition to the TRF model (103). Also the NRI was not significantly increased, although a modest but significant increase in the IDI was evident (103). In the MultiEthnic Study of Atherosclerosis (MESA), evaluating incident CVD events (CHD, stroke, and fatal CVD) over a maximum of 5.3 years of follow-up, not only was coronary artery calcium (CAC) associated more strongly than carotid IMT with the risk of incident CVD, but a ROC analysis also suggested that CAC score was a better predictor of incident CVD than was IMT, with AUC of 0.81 versus 0.78, respectively, after adjustment for TRFs (102).…”

Section: Intima -Media Thicknessmentioning

confidence: 89%

Section: Intima -Media Thicknessmentioning

confidence: 90%

“…In numerous population-based prospective studies carotid IMT, other than carotid plaque, was significantly (or border-line significantly) associated to incident coronary and cerebrovascular events, even after TRF adjustment (Supplementary Table III) (24,25, 90 -107), but as for circulating biomarkers there is seldom evidence of an increase in discrimination and reclassification (24,90,94,102,103,108). In a communitybased cohort study in a Chinese population a significant association was found between carotid IMT and incidence of CHD and stroke in Chinese adults, but neither the AUC for CHD nor that for stroke significantly improved after IMT addition to the TRF model (103).…”

Section: Intima -Media Thicknessmentioning

confidence: 99%

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From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population

et al. 2011

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From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Abstract Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. In the last decades numerous markers have been considered and investigated for the prediction of CV events, but only a few of them resulted in improved global risk assessment beyond traditional risk factors when incorporated into coronary evaluation scores. Recent genetic studies have pointed out a few but consistent loci or genes which are independently associated with CV risk. The idea is fascinating that these genetic markers could lead to improved individual CV risk assessment and tailored pharmacological interventions. In this brief review we will not make a systematic review of all non-genetic and genetic markers of CV risk but we will try to make a brief overview of the most interesting ones with the aim to underline potential ' pros ' and ' cons ' of their implementation in clinical practice. From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population

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Carotid Artery Intima-Media Thickness, Carotid Plaque and Coronary Heart Disease and Stroke in Chinese

Cited by 65 publications

References 56 publications

Increased serum visfatin as a risk factor for atherosclerosis in patients with ischaemic cerebrovascular disease

Increased serum visfatin as a risk factor for atherosclerosis in patients with ischaemic cerebrovascular disease

Constructing the Prediction Model for the Risk of Stroke in a Chinese Population

From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population

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