Increased serum visfatin as a risk factor for atherosclerosis in patients with ischaemic cerebrovascular disease

Kong, Qingxia; Xia, Min; Liang, Ru-qing; Li, Lei; Cu, Xu; Sun, Zhuo-xiang; Hu, Junli

doi:10.11622/smedj.2014091

Cited by 21 publications

(12 citation statements)

References 23 publications

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“…NAMPT is elevated in symptomatic atherosclerotic carotid plaque [13], and increased serum levels of NAMPT have been associated with recent ischemic cerebral events in patients with carotid atherosclerosis [27]. Our findings in the present study suggest that increased NAMPT expression in atherosclerotic disorders is not restricted to immune cells within the atherosclerotic lesion, but is also found in circulating mononuclear cells.…”

Section: Discussionsupporting

confidence: 58%

Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages

et al. 2015

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Section: Discussionsupporting

confidence: 58%

Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages

et al. 2015

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“…ischemic cerebrovascular events associated with carotid atherosclerosi. 13) In this study, we found that NAMPT is expressed not only in atherosclerotic plaques, but also it increased in the PBMC and the plasma in the patients with ACS compared with the normal subjects. Moreover, the expression of extracellular NAMPT (eNAMPT) was related to the M2 polarization of peripheral blood macrophages in patients with ACS; eNAMPT is associated with immunosuppressive M2 macrophages.…”

Section: Discussionmentioning

confidence: 53%

Nicotinamide Phosphate Transferase (NAMPT) Increases in Plasma in Patients with Acute Coronary Syndromes, and Promotes Macrophages to M2 Polarization

et al. 2018

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Atherosclerosis is an inflammatory disease; monocytes and macrophages play an important role in the progression of this disease. However, the mechanisms are not fully understood yet. Nicotinamide phosphate transferase (NAMPT) is the rate limiting enzyme in the synthesis of NAD, but extracellular NAMPT shows the characteristics of cytokines/adipokines, suggesting that it may be a link between metabolism and inflammation. In this study, we compared the expression levels of the NAMPT/NAD+/Sirt1 signaling pathway as well as NAMPT, CRP and IL-6 in the peripheral blood mononuclear cell (PBMC), and plasma in patients with acute coronary syndromes and healthy subjects, and analyzed their association with macrophage polarization. The relationship between eNAMPT and iNAMPT and the polarization of macrophages was analyzed by NAD+, NAMPT blocker, and neutralizing antibody treatment. The results showed that the expression of the NAMPT/NAD+/Sirt1 signaling pathway was up-regulated in the peripheral blood of patients with ACS. Inhibition of iNAMPT expression can reduce M1 polarization; however, there was no significant effect on eNAMPT secretion and M2 polarization. Neutralizing eNAMPT by neutralizing antibodies can reduce M2 polarization and decrease the expression levels of IL-10, IL-13, IL-4 and IL-1ra. The addition of NAD+ in the cell culture supernatant had no significant effect on the polarization of M1 but increased the M2 polarization and the expression levels of IL-10 and IL-1ra. Our findings suggested that NAMPT is involved in the pathogenesis of atherosclerosis; the increased expression of eNAMPT in ACS patients may play a protective role by the up regulation of the NAMPT/NAD+/Sirt1 signaling pathway.

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“…Increased visfatin promotes the proliferation of vascular smooth muscle cells and of fibroblasts, and plays a part in myocardial fibrosis and cardiac remodeling, which is an important process of hypertension [43]. Kong et al proved that increased serum visfatin levels were associated with the occurrence of atherosclerosis in patients with ischemic cerebral infarction [44]. These funding might suggest a potential role of this adipokine in vascular function.…”

Section: Discussionmentioning

confidence: 99%

Visfatin Level and The Risk of Hypertension and Cerebrovascular Accident: A Systematic Review and Meta-Analysis

Wang

et al. 2019

Horm Metab Res

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High blood pressure is related with increased cerebrovascular accident. High visfatin / NAMPT(nicotinamide phosphoribosyltransferase) plasma levels may promote vascular inflammation and atherosclerotic plaque destabilization and have been evaluated as a marker for identifying stages of essential hypertension. However, its role in the pathogenesis of hypertension and cerebrovascular accident (CVA) is still uncertain. In order to review and meta-analyze observational studies investigating visfatin concentration and the risk for hypertension or CVA, a systematic search of PubMed, ovid EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) until December 07, 2016 was performed. After data extraction and quality assessment, a meta-analysis was performed using RevMan 5.3 and STATA 14.0. A total of 1693 adults from 8 studies for hypertension (974 with hypertension) and 1696 adults from 7 CVA studies (957 with CVA) were enrolled in the current meta-analysis. Cochran’s Q-statistic and I2 test were applied to estimate the heterogeneity of the studies. The fixed-effects were used to compute the weighted mean difference in visfatin levels. Plasma visfatin concentration was much higher in hypertension and CVA patients than in healthy individuals. These evidences suggested the association of hypertension and CVA with higher plasma visfatin level.

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Increased serum visfatin as a risk factor for atherosclerosis in patients with ischaemic cerebrovascular disease

Cited by 21 publications

References 23 publications

Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages

Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages

Nicotinamide Phosphate Transferase (NAMPT) Increases in Plasma in Patients with Acute Coronary Syndromes, and Promotes Macrophages to M2 Polarization

Visfatin Level and The Risk of Hypertension and Cerebrovascular Accident: A Systematic Review and Meta-Analysis

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