Carotenoids modulate the hallmarks of cancer cells

Niranjana, R.; Gayathri, R.; Mol, Stephen Nimish; Sugawara, Tatsuya; Hirata, Takashi; Miyashita, Kazuo; Ganesan, Palanivel

doi:10.1016/j.jff.2014.10.017

Cited by 98 publications

(70 citation statements)

References 145 publications

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“…β-Cryptoxanthin (β-Cx) is a major dietary pro-vitamin A carotenoid provided by citrus juices (Granado-Lorencio, Olmedilla, Blanco, & Rojas-Hidalgo, 1996). There are scarce data about its potential to modulate the growth of cancer cells (Niranjana et al, 2014). Likewise, a few in vivo and in vitro studies suggest that β-Cx might prevent colon cancer.…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative effect of main dietary phytosterols and β-cryptoxanthin alone or combined in human colon cancer Caco-2 cells through cytosolic Ca+2 – and oxidative stress-induced apoptosis

Cilla

Attanzio

Barberá

et al. 2015

Journal of Functional Foods

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Section: Introductionmentioning

confidence: 99%

Anti-proliferative effect of main dietary phytosterols and β-cryptoxanthin alone or combined in human colon cancer Caco-2 cells through cytosolic Ca+2 – and oxidative stress-induced apoptosis

Cilla

Attanzio

Barberá

et al. 2015

Journal of Functional Foods

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“…It is one of the most abundant carotenoids (Kameji, Mochizuki, Miyoshi, & Goda, 2010;Lakshminarayana, Raju, Krishnakantha, & Baskaran, 2005;Priyadarshani & Jansz, 2014). As a precursor of vitamin A, β-carotene exhibits antioxidant, anti-inflammatory, and anti-cancer activities (Guo et al, 2015;Niranjana et al, 2015), and has been shown to play a role in the prevention of cardiovascular disease (Gaziano et al, 1995). β-carotene has been reported to suppress LPS-induced inflammatory responses by inhibiting nuclear factor kappa B (NF-κB) translocation in RAW264.7 cell lines (Bai et al, 2005).…”

mentioning

confidence: 99%

β‐carotene attenuates lipopolysaccharide‐induced inflammation via inhibition of the NF‐κB, JAK2/STAT3 and JNK/p38 MAPK signaling pathways in macrophages

Pan

Zheng

2018

Animal Science Journal

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β-carotene is one of the most abundant carotenoids, has potential anti-inflammatory effect, it has been reported that β-carotene could suppress LPS-induced inflammatory responses by inhibiting nuclear factor kappa B (NF-κB) translocation, but the more detailed molecular mechanisms underlying the anti-inflammatory action of βcarotene remain to be fully understood. In this study, we investigated the influence of β-carotene on the activation of JAK2/STAT3, MAPK, and NF-κB signaling pathway induced by LPS in RAW264.7 cells and peritoneal macrophages. Cells were treated with different concentrations of β-carotene for 3 hr after LPS treatment for 24 hr. The mRNA expression and the release of IL-1β, IL-6, and TNF-α were evaluated by RT-PCR and ELISA, and the level of signaling proteins of JAK2/STAT3, MAPK, and NF-κB signaling pathway were detected by Western blot. The results showed that β-carotene significantly suppressed (p < 0.05) LPS-induced release of IL-1β, IL-6, and TNF-α and their mRNA expression. LPS-induced JAK2/STAT3, IκB/ NF-κB p65, JNK/p38 MAPK signal activation were significantly attenuated (p < 0.05) by β-carotene in a dose-dependent manner. In conclusion, β-carotene could attenuate LPS-induced inflammation via inhibition of the NF-κB, JAK2/STAT3, and JNK/p38 MAPK signaling pathways in macrophages.

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“…Tomato lipophilic compounds exert a beneficial effect on humans, as carotenoids possess an apoptotic inducing effect in cancer cells (reviewed in Niranjana et al, 2015), and lycopene has been demonstrated to reduce oxidized-LDL cholesterol levels (Abete et al, 2013).…”

mentioning

confidence: 99%

Antioxidant bioactive compounds in tomato fruits at different ripening stages and their effects on normal and cancer cells

Giudice

Raiola

Tenore

et al. 2015

Journal of Functional Foods

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Carotenoids modulate the hallmarks of cancer cells

Cited by 98 publications

References 145 publications

Anti-proliferative effect of main dietary phytosterols and β-cryptoxanthin alone or combined in human colon cancer Caco-2 cells through cytosolic Ca+2 – and oxidative stress-induced apoptosis

Anti-proliferative effect of main dietary phytosterols and β-cryptoxanthin alone or combined in human colon cancer Caco-2 cells through cytosolic Ca+2 – and oxidative stress-induced apoptosis

β‐carotene attenuates lipopolysaccharide‐induced inflammation via inhibition of the NF‐κB, JAK2/STAT3 and JNK/p38 MAPK signaling pathways in macrophages

Antioxidant bioactive compounds in tomato fruits at different ripening stages and their effects on normal and cancer cells

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