Objective-This systematic review evaluates the impact of aspirin on audiometric outcomes with respect to: (1) doses exceeding 325 mg daily, (2) doses of 325 mg daily or less, (3) studies applicable to the general populace, and (4) studies applicable to those with inflammatory conditions. It also assesses the impact of aspirin on (a) self-reported hearing loss, (b) noiseinduced audiometric changes, and (c) the adverse otological effects of aminoglycoside therapy.Data Sources-Computerized searches of MEDLINE, PubMed, Cochrane, and EMBASE databases were performed, updated through January 2014, and supplemented by manual searches and inquiries to topic experts.Review Methods-A systematic review was performed according to an a priori protocol. Data extraction was performed by 2 independent parties and focused on relevant audiological measurements, potential confounders, and study design elements associated with risk of bias, including utilization of randomization, prospective/retrospective data collection, and incorporation of blinding.
Results-The
Author ContributionsMeghann Elizabeth Kyle, acquisition of data, analysis and interpretation of data, drafting and editing manuscript, final approval; James C. Wang, acquisition of data, analysis and interpretation of data, contributing to manuscript, final approval; Jennifer J. Shin, analysis and interpretation of data, acquisition of data, drafting and editing manuscript, final approval.
DisclosuresCompeting interests: Jennifer J. Shin receives royalties from book publications: Evidence-based Otolaryngology (Springer International, 2008, Otolaryngology Prep and Practice (Plural Publishing, 2013). Sponsorships: None. Funding source: None.
Supplemental MaterialAdditional supporting information may be found at http://otojournal.org/supplemental. Author Manuscript shift); the effect was dose dependent and reversible in the short term. There were no audiometric data that confirm that long-term doses of 81 mg or 325 mg daily have no hearing consequences. Paradoxically, aspirin (in doses shown to be detrimental in isolation) had a protective effect when co-administered with intravenous gentamicin.
HHS Public AccessConclusions-With the large-scale population utilization of aspirin for cardiovascular prophylaxis, the potential risks to hearing health should be considered for future longitudinal study, particularly given that short-term effects may be reversible.