Ubiquitous Aspirin: A Systematic Review of Its Impact on Sensorineural Hearing Loss

Kyle, Meghann E.; Wang, James C.; Shin, Jennifer J.

doi:10.1177/0194599814541627a219

Cited by 12 publications

(18 citation statements)

References 25 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 For example, in the case reported here, the aspirin therapy was discontinued due to ototoxicity concerns, but a systematic review found the hearing loss associated with aspirin to be dose dependent only for doses exceeding 325 mg daily. 9 The authors of the review were not able to rule out lower-dose, longer-term aspirin therapy as a possible causative or contributing factor to hearing loss, but the risk of cardiovascular disease without aspirin is an important consideration in the decision-making process.…”

Section: Autoimmune Inner Ear Diseasementioning

confidence: 99%

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy

et al. 2017

View full text Add to dashboard Cite

Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric assessment in order to categorize the hearing loss as conductive, sensorineural, or mixed. Sudden sensorineural hearing loss and autoimmune inner ear disease are acute and subacute forms of sensorineural hypoacusia most likely to be reversed with prompt pharmacological intervention. Systemic or local corticosteroid therapy has the most evidence of benefit in patients with sudden sensorineural hypoacusia and is the best available first line therapy noted in clinical practice guidelines. Alternative immunosuppressant therapies have not been well studied, and many have serious toxicities that further complicate the benefit-risk assessment. There are no randomized comparisons of corticosteroid dosing regimens that evaluated clinically important outcomes, so expert opinion must serve as the basis for dosing recommendations. Clinicians need to involve patients with hypoacusia in the shared decision-making process, since partial or complete reversal of hearing loss can have substantial quality-of-life implications for affected patients.

show abstract

Section: Autoimmune Inner Ear Diseasementioning

confidence: 99%

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The likewise old remedy aspirin is known to cause tinnitus and impaired hearing when taken in overdose. A systematic review involving 185,000 individuals extracted from 37 publications has recently been published with the main aim to evaluate the effect on audiometric measurements in different dose ranges . The authors found sensorineural hearing loss documented for daily doses from 4 to 10 g per day with a reported threshold shift of 15–112 dB.…”

Section: Other Audiological Responses: Comparison Between Quinine Andmentioning

confidence: 99%

Concentration–Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms

Alván

Berninger

Gustafsson

et al. 2016

Basic Clin Pharma Tox

View full text Add to dashboard Cite

This review has the purpose to summarize concentration-effect studies made with quinine and to compare the effects on hearing between quinine and salicylate. Quinine and salicylate have roles in experimental hearing research and may induce pronounced and reversible hearing impairment when administered in sizeable doses. The quinine-induced increase in hearing threshold and its recovery can be analysed according to 'the psychophysical power function'. The power function is a special case of the Hill equation when the stimulus (e.g. a drug concentration) is exceedingly small compared with the concentration that would elicit a half-maximum response. Quinine and salicylate induce sensorineural hearing impairment and tinnitus when given in higher dose ranges in man. The drugs influence the presence, magnitude, and quality of audiological responses, such as spontaneous and evoked otoacoustic emissions. Quinine reversibly reduces frequency selectivity and hearing sensitivity, whereas the self-attained most comfortable speech level and the acoustic stapedius reflex are not affected, that is the dynamic range of hearing is reversibly reduced. This observation supports the view that quinine acts on the outer hair cell of the cochlea. Both drugs share a protective effect against the permanent hearing damages caused by gentamicin. This action is interpreted as a request for functioning mechanoelectric transducer (MET) channels to elicit the ill effect of aminoglycosides. Both drugs may interfere with the cochlear amplifier through blocking MET channels and the motor protein prestin. This review finds considerable overlap between type and extent of pharmacological actions of quinine and salicylate, supposedly caused by partly shared mechanisms of action but performed with different molecular mechanisms.The aim of this MiniReview was to explore key findings from the few concentration-effect (pharmacokinetic-pharmacodynamic, PK-PD) studies that have been performed with quinine, to understand the extent and mechanisms of reversibly impaired hearing. With respect to salicylate, concentration-effect studies are scarce. Considering the overlap of sensorineural effects of quinine and aspirin, we have compared studies on their respective mechanisms to interfere with hearing. Quinine has been used as a drug since the 17th century, in the beginning as bark from the cinchona tree. The most significant medical indication is severe malaria where it still has a role. It has been argued that the availability of quinine was a key factor in making Africa safe for non-immune Europeans as malaria was a deadly threat [1]. Quinine has been used to induce abortion and has killed many women because of its general toxicity. Both quinine and its isomer quinidine affect ion channels and cause life-threatening arrhythmia taken in overdose. Salicylate was known to the ancients and manufactured synthetically in the 19th century. Its neuropharmacological effects on hearing both peripherally and centrally have recently been updated [2].The heari...

show abstract

“…3 However, studies show that administration of high doses Aspirin (325 mg) had an ototoxic effect leading to hearing loss. 4 On the other hand, studies have shown that co-administration of Aspirin with gentamicin, which is considered to be ototoxic, had a protective effect against hearing loss, 5 also animal studies have shown that NSAIDs in low doses can protect against cochlear injury due to noise and aging, but the effect on human is yet to be determined. 6 In our study, we aimed to find out if administration of low dose Aspirin (81 mg) had a protective impact against hearing loss due to aging.…”

Section: Introductionmentioning

confidence: 99%

The effect of low dose Aspirin on age-related hearing loss

Al-Khatib

Alqarni

Aashi

et al. 2018

JOENTR

View full text Add to dashboard Cite

show abstract

Ubiquitous Aspirin: A Systematic Review of Its Impact on Sensorineural Hearing Loss

Cited by 12 publications

References 25 publications

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy

Concentration–Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms

The effect of low dose Aspirin on age-related hearing loss

Contact Info

Product

Resources

About