Associations between cardiovascular disease and its risk factors with hearing loss—A cross‐sectional analysis

Tan, Hsern Ern I.; Lan, N.; Knuiman, Matthew; Divitini, Mark; Swanepoel, De Wet; Hunter, Michael; Brennan‐Jones, Christopher G.; Hung, Joseph; Eikelboom, Robert H.; Maria, Peter L. Santa

doi:10.1111/coa.12936

Cited by 73 publications

(77 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first hypothesis is that hyperlipidaemia is related to hearing preservation. However, previous studies have demonstrated that hyperlipidaemia itself is a risk factor for hearing loss, especially in noise‐induced hearing loss . Therefore, the drugs used for hyperlipidaemia treatment, rather than the condition itself, may prevent or reduce the progression of hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Drugs for hyperlipidaemia may slow down the progression of hearing loss in the elderly: A drug repurposing study

Choo

Yoon

Choi

et al. 2018

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Hearing loss in the elderly causes communication difficulties, decreased quality of life, isolation, loneliness and frustration. The aim of this study was to identify the modifiable variables that may affect the progression of hearing loss in the elderly.A case-control study was conducted using two data sets. Data were extracted from the health examination survey of Ajou University Hospital (2010-2014) and the Korea National Health and Nutrition Examination Survey (2009-2012) data sets.Audiometry data were evaluated according to variables such as age, sex and drug use for underlying diseases. Logistic regression analysis was performed on the entire study population, and middle-aged and elderly groups using odds ratios (ORs). Factors including older age, female gender and diabetes mellitus were significantly associated with hearing levels in all age groups (OR [95% confidence interval, 95% CI], 0.375 [0.388-0.415], 1.202 [1.195-1.208], and 1.427 [1.183-1.721], respectively). However, when the results from the middle-aged and elderly groups were compared, medication for hyperlipidaemia had a significantly positive effect on the preservation of hearing in the elderly group (OR [95% CI], 0.713 [0.567-0.897]), but not in the middle-aged group (OR [95% CI], 0.967 [0.791-1.183]). People, especially those in the elderly group, exposed to medication for hyperlipidaemia are likely to have better hearing than those not exposed to such drugs. Thus, drugs prescribed for hyperlipidaemia may maintain hearing in the elderly. However, to overcome potential confounding-by unmeasured variables -that is present in this study, further studies must be performed with more elaborate research design and methodology. K E Y W O R D Sdrug repurposing, hearing loss, hearing loss in elderly, hyperlipidemia

show abstract

Section: Discussionmentioning

confidence: 99%

Drugs for hyperlipidaemia may slow down the progression of hearing loss in the elderly: A drug repurposing study

Choo

Yoon

Choi

et al. 2018

Basic Clin Pharma Tox

View full text Add to dashboard Cite

show abstract

“…However, the results of these studies were inconsistent. 12–17 Cross-sectional studies reported a positive association between hypertension and HI in Korea and in Indian workers in the iron and steel industries. 13 14 The same association was observed in a case-control study in Brazil, which also reported a positive association between hypertension and hearing loss.…”

Section: Introductionmentioning

confidence: 99%

“… 11 A recent study in Australia reported that current smoking, obesity, high serum triglycerides and brachial-ankle pulse wave velocity were positively associated with hearing loss in addition to diabetic condition and serum HDL cholesterol levels. 12 Regarding hypertension, several epidemiological studies examined the association between hypertension and HI. However, the results of these studies were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Association between hypertension and hearing impairment in health check-ups among Japanese workers: a cross-sectional study

et al. 2019

View full text Add to dashboard Cite

ObjectivesPrevention of hearing impairment (HI) is important because recovery of hearing is typically difficult. Epidemiological studies have examined the risk factors for HI. However, the association between hypertension and HI remains unclear. We aimed to clarify the association between hypertension and HI.DesignCross-sectional study.SettingJapanese workers in an information and communication technologies company.ParticipantsOf 24 823 employees of the same company, we recruited 13 475 participants who underwent hearing testing by audiometry in annual health check-ups and did not have missing data regarding body measurement, blood test results and drinking/smoking status (mean age: 49.4 years; males: 86.4%).Primary outcomesHearing tests were performed at two frequencies (1 kHz, 4 kHz). We defined the inability of participants to respond to 30 dB at 1 kHz and/or 40 dB at 4 kHz as overall moderate HI. We also defined moderate HI at 1 or 4 kHz as an abnormal finding at 1 or 4 kHz. We defined hypertension as ≥140 mm Hg systolic blood pressure and/or ≥90 mm Hg diastolic blood pressure and/or taking medication for hypertension. We examined the association between hypertension and HI after adjusting for age, sex, body mass index, smoking/drinking status, diabetes mellitus, hyperlipidaemia and proteinuria.ResultsModerate HI was identified in 980 participants (7.3%). Of these, 441 participants (3.3%) exhibited moderate HI at 1 kHz, and 787 participants (5.8%) exhibited moderate HI at 4 kHz. Subjects with hypertension showed a higher prevalence of any HI. The prevalence of overall moderate HI, moderate HI at 1 kHz and moderate HI at 4 kHz among subjects with hypertension was 8.7%, 4.3% and 6.8%, while those among subjects without hypertension was 6.9%, 3.0% and 5.6% (p<0.01, p<0.01 and p=0.01, respectively).ConclusionsHypertension was associated with moderate HI in Japanese workers.

show abstract

“…The literature provides data on the relationship between hearing loss and clinical manifestations of coronary heart disease [3]. Studies have also been conducted to identify the risk of cardiovascular disease in people with various hearing impairments [4]. Earlier, we discovered the influence of severe hearing pathology on the indicators of cardiac output and stroke volume [5,6].…”

Section: Introductionmentioning

confidence: 99%

The Aortic Elasticity in Hearing-Impaired Girls After Dynamic Load

2020

jcr

View full text Add to dashboard Cite

Persons with hearing impairments are a fairly large group of people whose physiological characteristics are poorly understood. Particular attention should be paid to the state of their cardiovascular system due to the fact that the body of a hearing-impaired person develops in reduced motor activity. When measuring hemodynamic parameters in real-time using an ultrasound monitor in girls with varying degrees of hearing loss, differences were revealed compared with those of normally hearing girls. We analyzed the following hemodynamic parameters at rest and after dynamic loading: aortic compliance (C), mean pressure gradient in aorta (Pmn), pulse arterial pressure (BPp), peak velocity (Vpk), and stroke volume variation (SVV). Higher values of mean pressure gradient in aorta, pulse blood pressure, and peak velocity after dynamic loading were obtained. Differences in the dynamics of aortic compliance indicator values were revealed. An assessment of aortic elasticity in girls with hearing impairment is given. These studies can be used during medical examinations in people with disabilities; when compiling guides for doctors and specialists in cardiology and functional diagnostics; in the preparation of teaching aids for specialists in age and sports physiology, teachers and trainers of specialized boarding schools for hearing-impaired and deaf children.

show abstract

Associations between cardiovascular disease and its risk factors with hearing loss—A cross‐sectional analysis

Abstract: Established cardiovascular disease and individual and combined cardiovascular disease risk factors were found to be associated with hearing loss. Future research should prospectively investigate whether targeting cardiovascular disease can prevent hearing loss.

Cited by 73 publications

References 30 publications

Drugs for hyperlipidaemia may slow down the progression of hearing loss in the elderly: A drug repurposing study

Drugs for hyperlipidaemia may slow down the progression of hearing loss in the elderly: A drug repurposing study

Association between hypertension and hearing impairment in health check-ups among Japanese workers: a cross-sectional study

The Aortic Elasticity in Hearing-Impaired Girls After Dynamic Load

Contact Info

Product

Resources

About