Cardiovascular risk factors and hemorheology Physical fitness, stress and obesity

Ernst, Edzard; T, Weihmayr; Schmid, Michael; Baumann, Matt; Matral, A.

doi:10.1016/0021-9150(86)90121-8

Cited by 100 publications

(39 citation statements)

References 39 publications

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“…24 The increased RCA in the overweight (Figure 1) as compared with a subset of the Third north Glasgow MONICA survey population is in agreement with previous studies in overweight NIDDM, 9 adults and children. 11,29,30 The overall 13% reduction achieved in this study is comparable with the results of other studies in healthy overweight subjects. 11 The association between reduced abdominal fat distribution and RCA could suggest a mechanism related to insulin resistance.…”

Section: Discussionsupporting

confidence: 88%

“…However other workers have found no clear evidence of a relationship between changes in haemorheological and WHR values. 11 Elevated whole blood and plasma viscosities have been shown in overweight subjects when compared with those within the range of 20±25 kgam 2 BMI, 29 and also in overweight subjects with an elevated WHR compared with those with an acceptable ratio (`0.8 for women,`1.0 for men). 31 Raised plasma and whole blood viscosities have been reported in studies of the overweight.…”

Section: Discussionmentioning

confidence: 99%

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Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

et al. 1997

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OBJECTIVE: To investigate the effect of a dietary intervention to reduce body weight on red cell aggregation (RCA), factor VII activity, plasminogen activator inhibitor (PAI) activity, tissue plasminogen activator (t-PA) antigen, ®brino-gen, whole blood and plasma viscosity, haematocrit and lipids. DESIGN: Open single stranded study of dietary intervention for weight loss in a volunteer sample. SUBJECTS: Forty-®ve subjects whose BMI exceeded 26 kgam 2 were recruited and received dietetic advice designed to reduce body weight by 0.5 kg per week. MEASUREMENTS: Body weight and waist and hip circumferences, dietary intake by seven day weighed inventory, RCA, factor VII activity, PAI activity, t-PA antigen, ®brinogen, whole blood and plasma viscosity, haematocrit and lipids. RESULTS: After 12 weeks of dietary intervention there were reductions in body weight and BMI by 5.9 (s.d. 3.3) kg and 1.9 (s.d. 1.0) kgam 2 respectively in males, and 4.1 (s.d. 2.9) kg and 1.6 (s.d. 1.1) kgam 2 in females (P`0.0001). Factor VII activity (P 0.0043), RCA (P 0.01) and t-PA antigen (P 0.016) were reduced in females after weight reduction but no differences were found in PAI activity, whole blood, plasma viscosity or haematocrit. The changes in factor VII activity and RCA were appropriate for the changes in BMI on the basis of the relationships of the risk factors with BMI in a cross sectional survey of a representative Scottish population. Plasma total cholesterol was reduced (P 0.016) but HDL cholesterol and triglycerides remained unchanged. There were signi®cant associations between the reductions in factor VII activity and BMI (r 0.395, P 0.013) and between the reductions in RCA and waist to hip ratio (r 0.350, P 0.04). No relationship was seen between changes in serum cholesterol and changes in factor VII activity or RCA. CONCLUSIONS: Modest weight loss, of 5% body weight, with conventional dietary intervention reduces two established risk factors for ischaemic heart disease (factor VII activity and RCA) which are generally elevated in those with increased body weight.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

et al. 1997

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“…25,26 Moreover the alteration of high shear rate blood viscosity may re¯ect a disorder of the normal erythrocyte deformability that was found to be very reduced in central obesity. 10,12 The coexistence of plasma hyperviscosity, reduced red cell deformability and increased erythrocyte aggregation (derived from the high values of blood viscosity at 1/200 ratio) 38 is more relevant in patients with central obesity, characterizing a deep rheological derangement in these subjects and an incipient risk of macrovascular and microvascular complications. The demonstration of increased plasma ®bronectin concentrations in our patients with central obesity may already identify early endothelial functional damage, since ®bronectin is a glycoprotein mainly derived from endothelial cells, during physiological and pathological conditions.…”

Section: Discussionmentioning

confidence: 99%

Hyperviscosity and microproteinuria in central obesity: relevance to cardiovascular risk

et al. 1997

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OBJECTIVES: To investigate the role of blood rheology changes in the occurrence of glomerular proteinuria in obese patients with central fat distribution. SUBJECTS: Fifty-nine obese out-patients (31 with central and 28 with peripheral body fat distribution) and 24 healthy subjects. MEASUREMENTS: Blood and plasma viscosity (Rotational viscometer CV100 HAAKE), erythrocyte deformability (whole-blood ®ltration time), ®brinogen (nephelometry), urinary excretion rates of albumin, IgG, transferrin and IgA (nephelometry). RESULTS: Higher blood viscosity (at low and high shear-rates), plasma viscosity, ®brinogen, erythrocyte aggregability and lower erythrocyte deformability were found in patients with central obesity than in patients with peripheral obesity (P`0.01) and in healthy subjects (P`0.001). Furthermore an increased urinary excretion rate of albumin (P`0.001), IgG (P`0.001), transferrin (P`0.01) and IgA (P`0.05) was found in patients with central obesity than in the other two groups. Blood hyperviscosity (at shear-rate 1 s 71 and 1/200 ratio) signi®cantly correlated with the amount of urinary excretion of proteins independently of the other clinical and metabolic variables. CONCLUSIONS: The data demonstrated haemorheologic disorders related to pathologic proteinuria in patients with central obesity. The interaction between these two components may increase the risk of widespread cardiovascular disease.

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“…13 -15 Nowadays, it has been accepted that MC-FAN is a useful device to analyze hemorheology related to pathophysiology in atherosclerotic disorders. 10 Lifestyle factors, (e.g., smoking 16,17 and physical activity 18 ), whose modification is one of the primary treatments for cardiovascular disease can affect hemorheology. However, unexpectedly, the relationships between common lifestyle habits and hemorheology, especially using MC-FAN, have not been fully confirmed.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Alcohol Habits and Hemorheology by a Micro Channel Method in a General Population

Kotani¹,

Adachi²,

Osaki

et al. 2008

Clinical Cardiology

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Background: Hemorheology plays an important role in the development of cardiovascular disease. The Micro Channel array Flow Analyzer (MC-FAN) (Hitachi Haramachi Electronics Co., Ltd., Bentencho, Japan) is currently considered a useful new device to analyze hemorheology. However, the relationships between various lifestyle habits and hemorheology, especially using MC-FAN, have still not been thoroughly investigated. Hypothesis: The study was undertaken to determine whether there could be some correlations of lifestyle factors to hemorheology by MC-FAN. Methods: A total of 250 asymptomatic Japanese subjects (male:female = 100:150; mean age = 49.7 y) without any medication were enrolled in the present study. Hemorheology was assessed by the whole blood passage time (WBPT) and was corrected by the saline passage time using MC-FAN. Subjects' lifestyle factors, such as smoking habits, alcohol habits, and physical activity, were self-reported. Results: Partial correlation analysis for WBPT, after controlling for age, gender, hematocrit, white blood cell count, body mass index, blood pressure, blood biochemical measures, and all lifestyle habits, revealed a significant and inverse correlation between alcohol habits of 1-3 go (amount of alcohol intake) and WBPT (r = −0.191, p = 0.003), in addition to a significant positive correlation between serum low-density lipoprotein (LDL) cholesterol and WBPT. Conclusions: These data suggest that alcohol habits may beneficially affect hemorheology by MC-FAN, expanding the protective effect of light-to-moderate alcohol consumption against cardiovascular disease.

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Cardiovascular risk factors and hemorheology Physical fitness, stress and obesity

Cited by 100 publications

References 39 publications

Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

Hyperviscosity and microproteinuria in central obesity: relevance to cardiovascular risk

Relationship Between Alcohol Habits and Hemorheology by a Micro Channel Method in a General Population

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