Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

Hankey, Catherine; Rumley, Ann; Lowe, G. D. O.; Woodward, Mark; Lean, Michael E. J.

doi:10.1038/sj.ijo.0800453

Cited by 18 publications

(12 citation statements)

References 28 publications

(40 reference statements)

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“…Hemorheological alterations have been described in overweight and obesity [6,13,17,35,49,54]. These hemorheological alterations are thought to cause cardiovascular disorders in overweight and obese individuals.…”

Section: Introductionmentioning

confidence: 99%

Overweight explains the increased red blood cell aggregation in patients with obstructive sleep apnea

Sinnapah

Cadelis

Waltz

et al. 2015

Clinical Hemorheology and Microcirculation

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Sleep apnea patients and obese subjects are overexposed to cardiovascular diseases. These two health conditions may be associated with hemorheological alterations which could increase the cardiovascular risk. The present study investigated the hemorheological characteristics in patients with overweight and/or sleep apnea to identify the main predictor of red blood cell (RBC) abnormalities in sleep apnea patients.Ninety-seven patients were subjected to one night sleep polygraphy to determine their sleep apnea status. Body mass index (BMI) and the apnea/hypopnea index (AHI) were determined for categorization of obesity and sleep apnea status. Blood was sampled for hematocrit, blood viscosity, RBC deformability, aggregation and disaggregation threshold measurements.BMI and AHI were positively associated and were both positively associated with RBC aggregation. Analyses of covariance and multiple regression analyses revealed that BMI was more predictive of RBC aggregation than AHI. No association of BMI classes and AHI classes with RBC deformability or blood viscosity was observed.This study shows that increased RBC aggregation in sleep apnea patients is caused by overweight. Therapies to improve blood rheology in sleep apnea patients, and therefore reduce the risk for cardiovascular disorders, should focus on weight-loss.

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Section: Introductionmentioning

confidence: 99%

Overweight explains the increased red blood cell aggregation in patients with obstructive sleep apnea

Sinnapah

Cadelis

Waltz

et al. 2015

Clinical Hemorheology and Microcirculation

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“…The risk for overweight smokers rises more steeply with BMI, to reach a 12-fold risk at BMI > 29 kg/m 2 . Obesity is undoubtedly an important primary cause of IHD and stroke, operating through the effects of weight gain on hypertension (Dyer et al 1994), hyperlipidaemia (Bjorntorp, 1990;Denke et al 1993Denke et al , 1994, NIDDM and increased blood coagulability (Hankey et al 1997). These metabolic effects relate specifically to the intra-abdominal fat accumulation, so although elevated BMI brings increased cardiovascular risk, at least in younger individuals, more apple-shaped ('android') fat distribution is a stronger risk factor.…”

Section: Obesity and Cardiovascular Diseasementioning

confidence: 99%

Pathophysiology of obesity

Lean

2000

Proc. Nutr. Soc.

122

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The rapidly rising prevalence of obesity, worldwide, has prompted re-evaluations of the definitions and diagnostic criteria, and of the extent of the burden it contributes to health care services. Although categorized arbitrarily for epidemiological purposes according to BMI > 25 kg/m2 (‘overweight’) and BMI > 30 kg/m2 (‘obese’), the disease itself (ICD code E.66) is the process of excess fat accumulation. It leads to multiple organ-specific pathological consequences, particularly if there is a tendency to intra-abdominal fat accumulation. The simplest field method to identify obesity and risk of medical problems is the waist circumference, and this method has found a special role in health promotion. Risks begin with waist > 80 cm (women) or > 94 cm (men). As a broad generalization, obesity produces few symptoms below the age of 40 years, but then several symptoms often develop; tiredness, breathlessness, back pain, arthritis, sweatiness, poor sleeping, depression and menstrual disorders all being common. The symptoms are often attributed to diseases in other body systems. Metabolic diseases like diabetes, hyperlipidaemia and, hypertension develop later, but the mean BMI at diagnosis of diabetes is 28 kg/m2. Ultimately, obesity increases the likelihood of myocardial infarction, stroke and several major cancers, but its biggest impact on health, especially in the elderly, is probably the multiplicity of effects on other body systems. The greatest challenge for public health is to develop effective preventive measures, recognizing that BMI > 25 kg/m2 before the age of 20 years is a very strong predictor of obesity and ill health in adulthood.

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“…14 The plan is based on an exchange system for three groups of food 'bread', 'meat' and 'fruit'. The 'bread' exchanges comprise foods rich in complex carbohydrates such as bread, cereals, rice, pasta and potatoes.…”

Section: Detailed Dietary Advicementioning

confidence: 99%

Weight management: a comparison of existing dietary approaches in a work-site setting

et al. 2002

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OBJECTIVES:(1) To compare the effectiveness a 2512 kJ (600 kcal) daily energy deficit diet (ED) with a 6279 kJ (1500 kcal) generalized low-calorie diet (GLC) over a 24 week period (12 weeks weight loss plus 12 weeks weight maintenance). (2) To determine if the inclusion of lean red meat at least five times per week as part of a slimming diet is compatible with weight loss in comparison with a diet that excludes lean red meat. DESIGN: Randomized controlled trial. SETTING: Large petrochemical work-site. PARTICIPANTS: One-hundred and twenty-two men aged between 18 and 55 y. MAIN OUTCOME MEASURES: Weight loss and maintenance of weight loss. INTERVENTION: Eligible volunteers were randomized to one of the four diet=meat combinations (ED meat, ED no meat, GLC meat, GLC no meat). One-third of subjects in each diet=meat combination were randomized to an initial control period prior to receiving dietary advice. All subjects attended for review every 2 weeks during the weight loss period. For the 12 week structured weight maintenance phase, individualized energy prescriptions were re-calculated for the ED group as 1.4 (activity factor)Â basal metabolic rate. Healthy eating advice was reviewed with subjects in the GLC group. All subjects were contacted by electronic mail at 2 week intervals and anthropometric and dietary information requested. RESULTS: No difference was evident between diet groups in mean weight loss at 12 weeks (4.3 (s.d. 3.4) kg ED group vs 5.0 (s.d. 3.5) kg GLC group, P ¼ 0.34). Mean weight loss was closer to the intended weight loss in the 2512 kJ (600 kcal) ED group. The dropout rate was also lower than the GLC group. The inclusion of lean red meat in the diet on at least five occasions per week did not impair weight loss. Mean weight gain following 12 weeks weight maintenance was þ 1.1 (s.d. 1.8) kg, P < 0.0001. No differences were found between groups. CONCLUSIONS: This study has shown that the individualized 2512 kJ (600 kcal) ED approach was no more effective in terms of weight loss than the 6279 kJ (1500 kcal) GLC approach. However the ED approach might be considered preferable as compliance was better with this less demanding prescription. In terms of weight loss the elimination of red meat from the diet is unnecessary. The weight maintenance intervention was designed as a low-input approach, however weight regain was significant and weight maintenance strategies require further development.

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Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

Cited by 18 publications

References 28 publications

Overweight explains the increased red blood cell aggregation in patients with obstructive sleep apnea

Overweight explains the increased red blood cell aggregation in patients with obstructive sleep apnea

Pathophysiology of obesity

Weight management: a comparison of existing dietary approaches in a work-site setting

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