Hyperviscosity and microproteinuria in central obesity: relevance to cardiovascular risk

Abstract

OBJECTIVES: To investigate the role of blood rheology changes in the occurrence of glomerular proteinuria in obese patients with central fat distribution. SUBJECTS: Fifty-nine obese out-patients (31 with central and 28 with peripheral body fat distribution) and 24 healthy subjects. MEASUREMENTS: Blood and plasma viscosity (Rotational viscometer CV100 HAAKE), erythrocyte deformability (whole-blood ®ltration time), ®brinogen (nephelometry), urinary excretion rates of albumin, IgG, transferrin and IgA (nephelometry). RESULTS: Higher blood viscosity (at low and high shear-rates), plasma viscosity, ®brinogen, erythrocyte aggregability and lower erythrocyte deformability were found in patients with central obesity than in patients with peripheral obesity (P`0.01) and in healthy subjects (P`0.001). Furthermore an increased urinary excretion rate of albumin (P`0.001), IgG (P`0.001), transferrin (P`0.01) and IgA (P`0.05) was found in patients with central obesity than in the other two groups. Blood hyperviscosity (at shear-rate 1 s 71 and 1/200 ratio) signi®cantly correlated with the amount of urinary excretion of proteins independently of the other clinical and metabolic variables. CONCLUSIONS: The data demonstrated haemorheologic disorders related to pathologic proteinuria in patients with central obesity. The interaction between these two components may increase the risk of widespread cardiovascular disease.

Association between Serum C-reactive Protein Levels and Microalbuminuria: A Population-Based Cross-Sectional Study in Northern Iwate, Japan

“…This observation suggests that low-grade inflammation as assessed by high serum sensitive CRP levels may play a role in the induction of microalbuminuria, and that urinary albumin excretion rate reflects not only established cardiovascular risk factors but also systemic low-grade inflammation in an apparently healthy population. In fact, several studies have shown that microalbuminuria is evident in subjects with central obesity without an apparent relationship to hypertension and diabetes (27,28).…”

Grupo sanguíneo, alimentación y sobrepeso/obesidad: Una Miscelánea

“…Un total de 11 artículos fueron identificados en la búsqueda, cinco fueron científicos 11,12,13,14,15 de los cuales de eliminaron tres 11,12,13 por no incluir una de las tres variables y seis estudios teóricos 6,7,8,16,17,18 de los cuales se excluyeron dos 6,8 por no contar con los criterios de inclusión de la relación entre el grupo sanguíneo con al menos una de las dos variables (Figura 1.1).…”

“…En base a lo anterior, el autor del artículo "Diet analysis: The ABO blood type diet" menciona que los alimentos incompatibles con su grupo sanguíneo desordenan la digestión, aglutinan su sangre, producen más residuos tóxicos y enfermedades, aceleran la acumulación de grasa corporal y con ello la OB 8 . Otros autores concuerdan con esta teoría de alimentación de acuerdo al grupo sanguíneo que se tenga y que el consumo de aquellos alimentos no compatibles con su grupo sanguíneo potencializan el desarrollo de múltiples enfermedades 16 , infecciones, alergias 17 y falla de ciertos órganos como el corazón 14 y propician el SP y OB 7,15,18 .…”

“…Se han encontrado pocos estudios científicos que han definido aquellos alimentos adecuados a su química sanguínea como alimentos que tienden a mejorar la digestión, evitan la inflamación abdominal, nutren de manera más eficiente, engordan menos, hacen que la persona sea menos propensa a enfermedades y generan mucha mas energía que los menos compatibles. Por su parte, los alimentos incompatibles con su grupo sanguíneo desordenan la digestión, aglutinan su sangre, producen más residuos tóxicos y enfermedades, aceleran la acumulación de grasa corporal y con ello la OB 7,8 .…”

Intra-Abdominal Fat and Elevated Urine Albumin Excretion in Men With Type 1 Diabetes

“…arlier studies documented associations between central obesity and elevated albumin excretion rate or other renal injury indicators in nondiabetic subjects (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). A retrospective study conducted in a Kaiser Permanente mixed diabetic-nondiabetic cohort suggested that obesity increased risk for progression to end-stage renal disease (12).…”