Cardiovascular Outcomes and Hospitalizations in Asian Patients Receiving Immune Checkpoint Inhibitors: A Population-based Study

Chan, Jeffrey Shi Kai; Lakhani, Ishan; Lee, Teddy Tai Loy; Chou, Oscar Hou In; Lee, Yan Hiu Athena; Cheung, Yiu Ming; Yeung, Hoi Wa; Tang, Pias; Ng, Kenrick; Dee, Edward Christopher; Liu, Tong; Wong, Wing Tak; Tse, Gary; Leung, Fung Ping

doi:10.1016/j.cpcardiol.2022.101380

Cited by 30 publications

(30 citation statements)

References 24 publications

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“…The ICD-9 codes used for identifying comorbid conditions and the outcome (HF) were summarized in Table S1. CDARS has been extensively used in prior studies and has been shown to have good diagnostic coding accuracy [19][20][21][22]. As only retrospective, deidentified data were used, the requirement for individual patient consent has been waived.…”

Section: Study Design and Populationmentioning

confidence: 99%

Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis

Chan²,

Guan

et al. 2022

Cardiovasc Diabetol

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Background The relationship between triglyceride-glucose (TyG) index, an emerging marker of insulin resistance, and the risk of incident heart failure (HF) was unclear. This study thus aimed to investigate this relationship. Methods Subjects without prevalent cardiovascular diseases from the prospective Kailuan cohort (recruited during 2006–2007) and a retrospective cohort of family medicine patients from Hong Kong (recruited during 2000–2003) were followed up until December 31st, 2019 for the outcome of incident HF. Separate adjusted hazard ratios (aHRs) summarizing the relationship between TyG index and HF risk in the two cohorts were combined using a random-effect meta-analysis. Additionally, a two-sample Mendelian randomization (MR) of published genome-wide association study data was performed to assess the causality of observed associations. Results In total, 95,996 and 19,345 subjects from the Kailuan and Hong Kong cohorts were analyzed, respectively, with 2,726 cases of incident HF in the former and 1,709 in the latter. Subjects in the highest quartile of TyG index had the highest risk of incident HF in both cohorts (Kailuan: aHR 1.23 (95% confidence interval: 1.09–1.39), PTrend <0.001; Hong Kong: aHR 1.21 (1.04–1.40), PTrend =0.007; both compared with the lowest quartile). Meta-analysis showed similar results (highest versus lowest quartile: HR 1.22 (1.11–1.34), P < 0.001). Findings from MR analysis, which included 47,309 cases and 930,014 controls, supported a causal relationship between higher TyG index and increased risk of HF (odds ratio 1.27 (1.15–1.40), P < 0.001). Conclusion A higher TyG index is an independent and causal risk factor for incident HF in the general population. Clinical Trial Registration URL: https://www.chictr.org.cn; Unique identifier: ChiCTR-TNRC-11,001,489.

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Section: Study Design and Populationmentioning

confidence: 99%

Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis

Chan²,

Guan

et al. 2022

Cardiovasc Diabetol

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“…Mortality data were acquired from the linked Hong Kong Death Registry, a governmental mortality registry for Hong Kong citizens which records causes of death in ICD‐9 or ICD‐10 codes. Both databases have been used extensively in research and demonstrated to have good coding accuracy and data completeness 9–12 …”

Section: Figurementioning

confidence: 99%

“…Both databases have been used extensively in research and demonstrated to have good coding accuracy and data completeness. [9][10][11][12] Patients with PCa who received ADT (medical castration or bilateral orchiectomy) between 1 January 1993 and 31 March 2021 were identified. There were no exclusion criteria.…”

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confidence: 99%

Long‐term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy

Chan¹,

Lee

Liu

et al. 2022

Eur J Clin Investigation

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“…Mortality data were acquired from the linked Hong Kong Death Registry, a governmental registry of mortality data for Hong Kong citizens. CDARS and the linked Hong Kong Death Registry have been used extensively in research, and have been demonstrated to have good coding accuracy and data completeness [17] , [18] , [19] , [20] , [21] , [22] .…”

Section: Methodsmentioning

confidence: 99%

HbA1c Variability and Cardiovascular Events in Patients with Prostate Cancer Receiving Androgen Deprivation Therapy

Chan¹,

Lee²,

Liu³

et al. 2023

European Urology Open Science

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Cardiovascular Outcomes and Hospitalizations in Asian Patients Receiving Immune Checkpoint Inhibitors: A Population-based Study

Cited by 30 publications

References 24 publications

Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis

Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis

Long‐term cardiovascular burden in prostate cancer patients receiving androgen deprivation therapy

HbA1c Variability and Cardiovascular Events in Patients with Prostate Cancer Receiving Androgen Deprivation Therapy

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