Cardiovascular Benefits of Black Cumin (Nigella sativa)

Shabana, Adel; El‐Menyar, Ayman; Asim, Mohammad; Al-Azzeh, Hiba; Thani, Hassan Al

doi:10.1007/s12012-012-9181-z

Cited by 74 publications

(65 citation statements)

References 78 publications

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“…Antioxidant agents are effective to combat excessive ROS activity and thus minimize lipid peroxidation [22,25]. TQ has shown to improve endothelial function by reducing oxidative stress [36]. However, its antiangiogenic effect is probably stronger in decelerating wound healing.…”

Section: Discussionmentioning

confidence: 99%

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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Objective: Nigella sativa and its active constituent thymoquinone (TQ) have been extensively documented for its pharmacological values, but its application in wound healing in particular in a diabetic wound healing model is less documented. Methods:In our study, alloxan-induced diabetic rats were used as a chronic delayed wound model and topical administration of TQ 10% w/v were used to assess the role and function of TQ in wound healing through wound contraction and histological analysis.Results: Although statistically insignificant, we found out that TQ accelerated wound healing in post-wounding day 3 (inflammatory phase), whereas aggressively decelerating wound healing in post-wounding day 7 (proliferation phase). In addition, our histological analyses of wound granulation tissues at post-wounding day 14 substantiate our claim by showing that TQ treatment had delayed wound healing progression of the diabetic rats. Conclusions:Our study shows that TQ accelerates wound healing during the inflammatory phase; however, decelerate rapidly during the proliferation phase. We speculate the acceleration of wound healing during the inflammatory phase was due to its well-documented antioxidant, anti-inflammatory, and antimicrobial properties while its deceleration of wound healing during the proliferation phase was due to its well-documented antiangiogenic effect.

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Section: Discussionmentioning

confidence: 99%

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Yusmin

Ahmad

2017

Asian J Pharm Clin Res

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“…NS has also been cited as an Islamic traditional medicine. It has been quoted by Prophet Muhammad (PBUH) that NS seeds are a remedy for all diseases except death [20]. Ibn Sina (Avicenna) has referred to NS in his book "the Canon of Medicine" as an energizer agent and a cure for fatigue [21].…”

Section: Methodsmentioning

confidence: 99%

“…Another major ingredient of NS volatile oil is the terpenoid derivative thymoquinone (18.4-24 %), which is the main biologically active ingredient of the plant [27]. Phytochemical analysis of NS fixed oil has revealed a rich content of unsaturated fatty acids including linoleic, oleic, linolenic, arachidic, palmitoleic, eicosadienoic, palmitic, stearic, and myristic acid [20].…”

Section: Phytochemistry Of Nsmentioning

confidence: 99%

“…These pharmacological effects include hypoglycemic [28][29][30][31], antihypertensive [32], antiinflammatory [33,34], and antioxidant [35,36] actions. Besides, there has been a surge of interest in studying the beneficial effects of NS in the treatment of cardiovascular diseases [20], cancer [37], [38] and gastrointestinal disorders [39]. There is also evidence showing that NS, both in the raw powdered and extract forms, has antimicrobial and antifungal actions [40,41].…”

Section: Biological Activitiesmentioning

confidence: 99%

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Ameliorative effects of Nigella sativa on dyslipidemia

Asgary

Sahebkar

Goli-malekabadi

2015

J Endocrinol Invest

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“…In last fi ve decades, many active ingredients have been extracted from Nigella sativa seeds and their pharmacological effects have been studied (7). In recent years, many studies have revealed the benefi ts of extraction used in a spectrum from infectious diseases to cardiovascular system diseases (8,9). The studies relevant to pharmacological properties of TQ have suggested that antioxidant and antiinfl ammatory effects can be effective but research on the subject has not been suffi ciently illuminated (10).…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory and antioxidant effects of thymoquinone on ceruleine induced acute pancreatitis in rats

Dur¹,

Kose²,

Kocyigit³

et al. 2017

BLL

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The aim of this study is to investigate the potential antioxidant and anti-infl ammatory effects of thymoquinone (TQ) on ceruleine-induced acute pancreatitis. MATERIAL AND METHODS: A total of 14 male Wistar albino rats were divided into 2 groups as follows: (1) normal saline-treated group and (2) thymoquinone-treated groups. For achieving acute pancreatitis, intraperitoneal (IP) cerulein, a stable cholecystokinin (CCK) analogue, was applied in a 50 mcg/kg dose 2 times in onehour interval in total. One hour after last ceruleine injection, IP 2 ml/kg isotonic saline solution was applied to the saline group and IP 5 mg/kg TQ was applied. The rats were sacrifi ced by decapitation 12 h after the last injection of last medication. Blood samples were taken, and serum interleukin-1β (IL-1β), amylase, lipase pancreatic, total antioxidant capacity (TAC), total oxidant status (TOS), and pancreatic Schoenberg scores were determined. Oxidative stress index (OSI) was calculated for each group. Results are given as mean ± SD. A value of p < 0.05 was accepted as statistically signifi cant. SPSS for Windows v15.0 was used for statistical analyses. RESULTS: The increased serum amylase, lipase levels and histopathological scoring of pancreatic tissue showed that acute pancreatitis was present in both groups. Furthermore, serum IL-1β level was signifi cantly reduced in TQ-administered group (p < 0.05). Although serum TAC level was high and TOS level was low, those changes were not statistically signifi cant. Nevertheless, OSI index, which was driven from TOS/TAC, was signifi cantly low in TQ groups (p < 0.05). Although TQ partially ameliorated the acute pancreatitis in terms of histopathological evaluations, the main effect of it was brought about by reducing the hemorrhage in acute pancreatitis (p < 0.05). CONCLUSION: In this study, it was shown that TQ can reduce the infl ammation and has a positive effect on the oxidative status of organism in infl ammatory cases such as acute pancreatitis. This is consistent with partial amelioration of acute pancreatitis in rats given TQ (Tab. 2, Fig. 4, Ref. 31). Text in PDF www.elis.sk.

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Cardiovascular Benefits of Black Cumin (Nigella sativa)

Cited by 74 publications

References 78 publications

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Effect of Thymoquinone on Wound Healing in Alloxan-Induced Diabetic Rats

Ameliorative effects of Nigella sativa on dyslipidemia

The anti-inflammatory and antioxidant effects of thymoquinone on ceruleine induced acute pancreatitis in rats

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