Ameliorative effects of Nigella sativa on dyslipidemia

Asgary, Sedigheh; Sahebkar, Amirhossein; Goli-malekabadi, Najmeh

doi:10.1007/s40618-015-0337-0

Cited by 45 publications

(24 citation statements)

References 62 publications

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“…Unlike pervasive evidence for the effects of NS use on the lipid profile, the administration of powdered NS seeds was reported to have had no significant effect on BP, serum lipid levels, blood sugar, or body weight in adults [73]. According to some meta-analyses, overall, the use of NS was shown to reduce the plasma levels of TC, LDL-C and TG, but its effect on HDL-C was not significant [74, 75]. Whereas the use of NS seed oil was observed to have greater effects on the serum TC and the LDL-C levels, versus the use of seed powder, elevation of the HDL-C levels was found only after supplementation with NS seed powder [75].…”

Section: Resultsmentioning

confidence: 99%

“…This finding shows that the use of NS supplements can improve the lipid profile and prevent CVDs both in healthy people and hyperlipidemic patients. The exact mechanisms of the lipid-modifying effects of NS are not known, but might be associated with the inhibition of intestinal cholesterol absorption, decreased hepatic cholesterol synthesis, and up-regulation of LDL receptors [74]. …”

Section: Discussionmentioning

confidence: 99%

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Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Mahdian²,

et al. 2017

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ObjectivesNigella sativa (black seed or black cumin), which belongs to the Ranunculacea family, is an annual herb with many pharmacological properties. Among its many active constituents, thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa (N. sativa) seeds, and it is the constituent to which most properties of this herb are attributed.MethodsPubMed-Medline, Scopus, and Web of Science databases were searched to identify randomized control trials (RCTs) investigating the therapeutic effects of N. sativa and/or TQ. In this review, we investigated the clinical uses of N. sativa and TQ in the prevention and the treatment of different diseases and morbidity conditions in humans.ResultsBlack seed and TQ are shown to possess multiple useful effects for the treatment of patients with several diseases, such as inflammatory and auto-immune disorders, as well as metabolic syndrome. Also, other advantages, including antimicrobial, anti-nociceptive and anti-epileptic properties, have been documented. The side effects of this herbal medicine appear not to be serious, so it can be applied in clinical trials because of its many advantages.ConclusionSome effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to allow for the next phase of clinical trials or drug developments. However, most of its other effects and applications require further clinical and animal studies.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Mahdian²,

et al. 2017

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“…The seeds of NS are claimed to play antibacterial [1,2], anti-inflammatory [3], immune-potentiating [4], antioxidant [5,6], hypoglycemic [7,8], antihypertensive [9], anti-obesity [10], bronchodilatory [11], neuro-and cardio-protective [12,13], and antidiarrhoic effects [14], Increasing evidence also supports hypolipidemic properties of NS [13,[15][16][17][18]. The NS seeds contain many bioactive constituents, such as antioxidant compounds (mainly represented by thymoquinone and dithymoquinone), flavonoids, sterols, and polyunsaturated fatty acids [15], and the lipid-lowering effect is likely mediated by a synergistic action of its different components.…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials

Sahebkar

Beccuti

Simental‐Mendía

et al. 2016

Pharmacological Research

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The effects of Nigella sativa (NS) on plasma lipid concentrations are controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to obtain a conclusive result in humans. PubMed-Medline, SCOPUS, Web of Science, and Google Scholar databases were searched (up to August 2015) to identify RCTs investigating the impact of NS on total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglycerides concentrations. A random-effects model and the generic inverse variance weighting method were used for quantitative data synthesis. Meta-regression, sensitivity analysis, and publication bias assessments were performed using standard methods. A total of 17 RCTs examining the effects of NS on plasma lipid concentrations were included. Meta-analysis suggested a significant association between NS supplementation and a reduction in total cholesterol (weighed-mean-difference [WMD]: -15.65mg/dL, 95% CI: -24.67, -6.63, p=0.001), LDL-C (WMD: -14.10mg/dL, 95% CI: -19.32, -8.88, p<0.001), and triglyceride levels (WMD: -20.64mg/dL, 95% CI: -30.29, -11.00, p<0.001). No significant effect on HDL-C concentrations (WMD: 0.28mg/dL, 95% CI: -1.96, 2.53, p=0.804) was found. A greater effect of NS seed oil versus seed powder was observed on serum total cholesterol and LDL-C levels, and an increase in HDL-C levels was found only after NS seed powder supplementation. NS has a significant impact on plasma lipid concentrations, leading to lower total cholesterol, LDL-C, and TG levels while increased HDL-C is associated with NS powder only. Further RCTs are needed to explore the NS benefits on cardiovascular outcomes.

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“…In previous studies, many effects of TQ including antioxidant,5 anti-inflammatory,6 analgesic,7 anti-asthmatic,8 and antimicrobial9 effects were found, and a cell reproduction inhibitory effect in many types of cancer was also detected 10,11. It has very few documented side effects 12. In recent years, studies13 have suggested that TQ has a neuroprotective effect on the CNS.…”

mentioning

confidence: 99%

Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats

Beyazçiçek

Ankaralı

Beyazçiçek

et al. 2016

NSJ

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Objective:To investigate the effects of thymoquinone (TQ) in a penicillin-induced epilepsy model in rats.Methods:This experimental study included 56 adult male Wistar rats. Experiments were performed in the Research Laboratory of the Department of Physiology, Medical School, Duzce University, Duzce, Turkey, between October 2013 and December 2014. Animals were divided into the following 7 groups: sham, control, only thymoquinone, vehicle (Dimethylsulfoxide), and doses of 10, 50, and 100 mg/kg of TQ. After rats were anesthetized, the left part of the skull was removed. A pair of silver/silver chloride electrodes was placed on the somatomotor area, and electrocorticographic recording was started. After 5 minutes basal activity was recorded, and TQ was applied intraperitoneally. At the thirtieth minute after TQ, epileptiform activity was induced by intracortical penicillin. The first spike latency, spike frequency, and the amplitude of epileptiform activity were analyzed statistically.Results:The different doses of TQ significantly increased the latency time to onset of first spike wave, and decreased the frequency, and amplitude of epileptiform activity in the first 20 minutes compared with the control group.Conclusion:Thymoquinone shows potential as an antiepileptic drug resulting from its effects of prolonged latency time, and reduced spike wave frequency and amplitude of epileptiform activity.

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Ameliorative effects of Nigella sativa on dyslipidemia

Abstract: Overall, the evidence from experimental and a clinical studies suggests that NS seeds are a promising natural therapy for dyslipidemic patients.

Cited by 45 publications

References 62 publications

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials

Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats

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