Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity

Anna, Maurício de Sant; Carneiro, João Régis Ivar; Carvalhal, Renata Ferreira; Torres, Diego de Faria Magalhães; Cruz, Gustavo Gavina da; Quaresma, José Carlos do Vale; Lugon, Jocemir Ronaldo; Guimarães, Fernando Silva

doi:10.5935/abc.20150125

Cited by 10 publications

(14 citation statements)

References 35 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies show that obesity leads to the development of noncommunicable diseases such as hypertension, hypercholesterolemia, insulin resistance, and type 2 diabetes [1][2][3], and also several previous studies have found changes in cardiac autonomic modulation in overweight and obese individuals [4][5][6][7][8], which may be more affected in obese individuals (body mass index (BMI) ≥35.0 kg/m 2 ) [9]. is impairment occurs through an imbalance in the autonomic nervous system (ANS), especially in increased sympathetic modulation and decreased vagal tone leading to decreased heart rate variability (HRV) [5,7,10].…”

Section: Introductionmentioning

confidence: 99%

“…is impairment occurs through an imbalance in the autonomic nervous system (ANS), especially in increased sympathetic modulation and decreased vagal tone leading to decreased heart rate variability (HRV) [5,7,10]. e measurement of these patterns can provide a sensitive and early indicator of serious health impairment in obese individuals with a higher risk of multimorbidity and early mortality [9], as they can be indicators of risk of death and cardiovascular disease [2,11,12], such as coronary artery disease, myocardial infarction, sudden death, heart failure and arrhythmias [7,13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals

et al. 2020

View full text Add to dashboard Cite

Obesity leads to an imbalance in the autonomic nervous system, especially in increased sympathetic modulation and decreased vagal tone, and some anthropometric, metabolic, and lifestyle variables may increase the risk of developing cardiovascular disease. Objective. To analyze the association between cardiovascular autonomic modulation and biochemical and anthropometric markers, food intake, and physical activity level in severely obese individuals. Methodology. The present study is a cutout of a randomized clinical trial “Effect of nutritional intervention and olive oil in severe obesity” (DieTBra Trial), where the baseline data were analyzed. Anthropometric data, biochemical exams, heart rate variability (HRV), accelerometry, and 24 h recall (R24H) of obese patients (body mass index BMI ≥35 kg/m2) were collected. Results. 64 obese patients were analyzed, with a mean age of 39.10 ± 7.74 years (27 to 58 years). By HRV analysis, in the frequency domain, the obese had a higher predominance of sympathetic autonomic modulation (low frequency (LF) 56.44 ± 20.31 nu) and lower parasympathetic modulation (high frequency (HF) 42.52 ± 19.18 nu). A negative association was observed between the variables Homeostasis Evaluation Model (HOMA-IR) and HF (p=0.049). In the physical activity analysis, there was a negative association between moderate to vigorous physical activity and the sympathetic component (p=0.043), and for sedentary time (ST), there was a negative association with HF (p=0.049) and LF/HF (p=0.036) and a positive association with LF (p=0.014). For multiple linear regression, waist circumference (WC) and HOMA-IR values were negatively associated with HF (β = −0.685, p=0.010; β = −14.989, p=0.010; respectively). HOMA-IR (β = 0.141, p=0.003) and the percentage of lipids ingested (β = −0.030, p=0.043) were negatively associated with LF/HF. Conclusion. Among the cardiovascular risk variables studied, insulin resistance and central adiposity showed the greatest influence on cardiac autonomic modulation of obese, increasing the risk for cardiovascular disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals

et al. 2020

View full text Add to dashboard Cite

show abstract

“…For example, obese pregnant women are more likely to give birth to heavier babies (Carolina, 2014; Sebire, et al., 2001). Obesity has been found to be associated with significantly lower heart rate variability in adult women (Karason, Molgaard, Wikstrand, & Sjostrom, 1999; Rossi, 2015; Sant Anna Junior, 2015). Dragan and Akhtar-Danesh (2007) report that higher body mass index (BMI) may also be associated with more severe forms of depression.…”

mentioning

confidence: 99%

Maternal depression during pregnancy is associated with increased birth weight in term infants

Ecklund‐Flores

Myers

Monk

et al. 2017

Developmental Psychobiology

View full text Add to dashboard Cite

Previous research of maternal depression during pregnancy suggests an association with low birth weight in newborns. Review of these studies reveals predominant comorbidity with premature birth. This current study examines antenatal depression and birth weight in term, medically low-risk pregnancies. Maternal physiological and demographic measures were collected as well. In total, 227 pregnant women were recruited to participate in four experimental protocols at Columbia University Medical Center. Results indicate that depressed pregnant women who carry to term had significantly higher heart rates, lower heart rate variability, and gave birth to heavier babies than those of pregnant women who were not depressed. Low income participants had significantly higher levels of depression, as well as significantly higher heart rates and lower heart rate variability, than those in higher income groups. In full-term infants, maternal prenatal depression appears to promote higher birth weight, with elevated maternal heart rate as a likely mediating mechanism.

show abstract

“…Вегетативний профіль у осіб похилого та старечого віку з нормальною вагою тіла характеризується зниженням парасимпатичної активності протягом доби при нормальній симпатичній активності [4]. При цьому в ряді робіт показано зниження активності обох ланок: як симпатичної, так і парасимпатичної нервової системи [6,7]. Розуміння особливостей вегетативної дисфункції при ожирінні має як тера-певтичне, так і профілактичне значення і дозволить проводити ефективну профілактику ускладнень при ожирінні у осіб усіх вікових груп.…”

Section: обґрунтування дослідженняunclassified