Cardiovascular and Neuromuscular Effects of Org NC 45, Pancuronium, Metocurine, and d-Tubocurarine in Dogs

Effect of neuromuscular blocking agents pancuronium bromide and its monoquaternary analogue Org NC 45 on regional blood flow and cardiac metabolism in pigs

“…As has been usually noted in several previous studies [Saxena and Bonta, 1970;Smith et al, 1970;Seed and Chamberlain, 1977;Roizen and Feeley, 1978;Roizen et al, 1979;Booij et al, 1980;Krieg et al, 19801, we found that pancuronium increased heart rate and cardiac contractility though blood pressure moderately decreased due to peripheral vasodilatation. The increased oxygen demand in these pigs with normal coronary artery was adequately met by a combination of increased blood flow to, and oxygen extraction by, the myocardium.…”

“…However, in these pigs with normal coronary arteries, the increase in the myocardial oxygen demand was adequately met by increased myocardial oxygen supply and extraction. In a dose (300 pg.kg-'), which is about seven to ten times the EDw for muscle paralysis in most species tested [Durant et al, 1979[Durant et al, , 1980Booij et al, 1980;Krieg et al, 1980, and is two to three times that used for tracheal intubation in man [Bowman, 19801, Org NC 45 had no systemic or regional hemodynamic or biochemical effects. Though substantially higher doses (750 and 1500 pg.kg-') did decrease arterial blood pressure, LV dP/dt,,,,, and blood flow to brain, liver, and kidneys in the pig, Org NC 45 appears to be safer than pancuronium in clinically relevant dose range.…”

“…Recent studies have shown that a monoquaternary analogue of pancuronium, Org NC 45, possesses a highly selective neuromuscular blocking activity. This compound, unlike the parent drug, lacks cardiac muscarinolytic activity, does not cause tachycardia [Durant et al, 1979[Durant et al, , 1980Booij et al, 1980;Marshall et al, 1980a,b] and, therefore, would not be expected to increase myocardial oxygen demand.…”

Diabetes mellitus affects the duration of action of vecuronium in dogs

“…Vecuronium (0.1 mg kg )1 ) administered to nondiabetic dogs anaesthetized with isoflurane in the current study produced a duration of blockade of 16.8 ± 4.2 minutes when evaluated by tactile response to TOF stimulation, which is similar to that (Booij et al 1980), as assessed by the dose which produced a 90% depression of twitch tension and 35.8 ± 2.5 lg kg )1 (Thut et al 1994) derived by mathematical techniques. Using the TOF count, Jones (1985a) reported a mean time to T1 reappearance of 13.4 minutes and Sarrafzadeh-Rezaei & Clutton (2009) reported a duration of total blockade of 15.2 minutes for vecuronium 0.05 mg kg )1 when using a TOF method on the ulnar nerve.…”

Alfentanil combined with vecuronium or pancuronium: haemodynamic implications

“…for the inter-group haemodynamic comparisons, and the ~2 test was used for frequencies. P< 0.05 indicates a statistically significant differ-nomic activity (1,2), it may in connection with vagotonizing drugs, e*g* Opiates, induce a in heart rate (3,4), and indeed, numerous cases of bradycardia (5,6 ) and even asystole have been reported (7-1 1). This study heart rate and tion and following endotracheal intubation in patients receiving alfentanil and either vecuronium or pancuronium.…”