Diabetes mellitus affects the duration of action of vecuronium in dogs

Clark, Louise; Leece, Elizabeth A; Brearley, J.C.

doi:10.1111/j.1467-2995.2012.00714.x

Cited by 13 publications

(5 citation statements)

References 26 publications

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“…; Clark et al. ). This technique measures the compound motor action potential produced in muscles after electrical stimulation of a peripheral nerve.…”

Section: Introductionmentioning

confidence: 98%

Differences between acceleromyography and electromyography during neuromuscular function monitoring in anesthetized Beagle dogs

Sakai

Martin‐Flores

Tomak

et al. 2015

Veterinary Anaesthesia and Analgesia

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“…; Clark et al. ). This technique measures the compound motor action potential produced in muscles after electrical stimulation of a peripheral nerve.…”

Section: Introductionmentioning

confidence: 98%

Differences between acceleromyography and electromyography during neuromuscular function monitoring in anesthetized Beagle dogs

Sakai

Martin‐Flores

Tomak

et al. 2015

Veterinary Anaesthesia and Analgesia

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“…The duration of action of atracurium, a benzylisoquinolinium and parent compound to cisatracurium, was not different between non‐diabetic and diabetic dogs 23 . However, use of vecuronium and rocuronium in diabetics, both steroidal NMBAs, resulted in a shorter duration of action and necessitated higher rate of infusion 24,25 . Unfortunately, the number of diabetic dogs in our study is too small to examine any possible associations.…”

Section: Discussionmentioning

confidence: 75%

“…23 However, use of vecuronium and rocuronium in diabetics, both steroidal NMBAs, resulted in a shorter duration of action and necessitated higher rate of infusion. 24,25 Unfortunately, the number of diabetic dogs in our study is too small to examine any possible associations.…”

Section: F I G U R Ementioning

confidence: 94%

Duration of neuromuscular block is more variable and recovery time is shorter with rocuronium than cisatracurium in anesthetized dogs

Martin‐Flores

Hackman

Araos

et al. 2023

Veterinary Ophthalmology

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ObjectiveTo compare the variability in the duration of action of a single dose of rocuronium or cisatracurium, and duration of subsequent top‐up doses in anesthetized dogs.AnimalsThirty dogs requiring ophthalmic surgery with neuromuscular block.ProceduresNeuromuscular function was monitored with train‐of‐four (TOF) and acceleromyography. Dogs received an initial dose of rocuronium 0.6 mg/kg, or cisatracurium 0.15 mg/kg IV, which produced complete neuromuscular block. Upon return of the first response (T1) of TOF, a third of the initial dose was repeated. The duration of the initial dose and its variability were compared between agents. Duration of subsequent top‐up doses was assessed with mixed effect models. Spontaneous (from last return of T1) or neostigmine‐enhanced (from administration to complete recovery) recovery times were measured for each agent.ResultsDuration of action of the initial dose was [median (range)] 25 (10–60) min with rocuronium and 35 (15–45) min with cisatracurium (p = .231). The variability of rocuronium was 3.25 times larger than cisatracurium (p = .034). Duration of top‐up doses did not vary for either agent. Spontaneous recovery was shorter for rocuronium [15 (10–20) min] than cisatracurium [25 (15–45) min] (p = .02). Neostigmine‐enhanced recovery times were 5 (5–25) for rocuronium and 10 (5–10) for cisatracurium (p = .491).ConclusionsDuration of action for a single dose is significantly more variable with rocuronium than cisatracurium. Time to spontaneous recovery was longer for cisatracurium, and cases of unexpectedly long recovery times were observed with both agents. Objective monitoring is recommended.

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“…The amount of benzodiazepines, as well as the total dose of fentanyl, lidocaine, cis-atracurium and dexamethasone administered were not correlated with the duration of the NMB. The age and sex,39 bodyweight and number of diabetic dogs40–42 were not significantly different between groups and had no correlation with the NMB duration. No pregnant43 dogs or those with renal and hepatic disease44 45 were included in the study.…”

Section: Discussionmentioning

confidence: 82%

Onset and duration of cis‐atracurium neuromuscular block during fentanyl and lidocaine infusions in isoflurane‐anaesthetised dogs

Ida¹,

Van-Wijnsberghe²,

Tutunaru³

et al. 2020

Veterinary Record

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BackgroundThis retrospective study assessed the onset and duration of the neuromuscular block (NMB) induced by cis-atracurium 0.15 mg/kg intravenously with and without fentanyl or lidocaine infusions in 45 isoflurane-anaesthetised dogs.MethodsDogs with neuromuscular function assessed by a calibrated train-of-four (TOF) monitor with stimulation (every 13 s) of the peroneal nerve were included. The onset and duration of the NMB were defined as the time from cis-atracurium administration until TOF=0 and the time during TOF=0 display, respectively.ResultsThe NMB onset was shorter during fentanyl (mean±sd) (1.9±0.7 minutes; P=0.0042) and lidocaine (2.0±0.7 minutes; P=0.0154) compared with control (2.9±0.8 minutes). The NMB duration was shorter in the fentanyl (27.5±7.3 minutes; P=0.0491), but not in the lidocaine group (32.3±6.9 minutes; P=0.0790), compared with control (33.7±9.1 minutes). The NMB onset was poorly but significantly correlated with the dose of fentanyl and lidocaine administered before cis-atracurium (r=−0.3396; P=0.0225). The fentanyl and lidocaine groups received more crystalloid and colloid boluses than the control.ConclusionsFentanyl and lidocaine shortened the NMB onset and the former decreased the NMB duration. Further prospective studies are required to clarify whether this was associated with an indirect decrease in blood pressure or a direct interaction between cis-atracurium and fentanyl and lidocaine.

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Diabetes mellitus affects the duration of action of vecuronium in dogs

Cited by 13 publications

References 26 publications

Differences between acceleromyography and electromyography during neuromuscular function monitoring in anesthetized Beagle dogs

Differences between acceleromyography and electromyography during neuromuscular function monitoring in anesthetized Beagle dogs

Duration of neuromuscular block is more variable and recovery time is shorter with rocuronium than cisatracurium in anesthetized dogs

Onset and duration of cis‐atracurium neuromuscular block during fentanyl and lidocaine infusions in isoflurane‐anaesthetised dogs

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