Cardiovascular Adaptation to High-Altitude Hypoxia

Ji, Ke; Wang, Lei; Xiao, Daliao

doi:10.5772/65354

Cited by 4 publications

(2 citation statements)

References 72 publications

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“…Chronic hypoxia is one of the factors that cause pulmonary hypertension, which affects to a greater degree the lungs of fetuses and newborns compared to adults, and significant effects on cardiovascular function can be seen (Ke et al, 2017). In particular, gestation under high-altitude conditions promotes postnatal pulmonary hypertension, due to cardiopulmonary dysfunction and remodeling with persistent effects even at sea level (Herrera et al, 2010) and risk of heart malformation (Penaloza and Arias-Stella, 2007;Steinhorn, 2010;Fuloria and Aschner, 2017).…”

Section: Introductionmentioning

confidence: 99%

Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

Navarrete

Chen

Aranda

et al. 2020

Front. Bioeng. Biotechnol.

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Section: Introductionmentioning

confidence: 99%

Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

Navarrete

Chen

Aranda

et al. 2020

Front. Bioeng. Biotechnol.

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“…Hypoxia being a potent driver of cardiac remodeling involving cardiomyocyte hypertrophy in mammals and both proliferation and hypertrophy in zebrafish (Jopling et al, 2012;Ke et al, 2017;Sun et al, 2009), we reasoned that it might trigger heart failure in our model. Supporting this hypothesis, hyperventilation and SRB appeared as characteristic manifestations in eng -/-.…”

Section: Early Detection Of Concomitant Hypoxic and Cardiac Stress Responses In Endoglin Deficient Zebrafishmentioning

confidence: 99%

Endoglin deficiency elicits hypoxia-driven congestive heart failure in zebrafish

Lelièvre

Bureau

Bordat

et al. 2021

Preprint

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Hereditary hemorrhagic Telangiectasia (HHT) also known as Rendu-Osler-Weber syndrome is a rare genetic disease relying on mutations affecting components of TGF-β/BMP signaling pathway in endothelial cells. This disorder is characterized by vascular dysplastic lesions or arterio-venous malformations prone to rupture and ensuing hemorrhages are thought to be responsible for iron deficiency anemia. Along with Activin receptor-like kinase ALK1, Endoglin (CD105) is involved in the vast majority of reported HHT cases. Unlike Type-1 TGF-β Receptor ALK1, Endoglin is not endowed with Ser/Thr kinase activity but serves as an ancillary receptor that modulates TGF-β receptor complex signaling. In this report, we characterized zebrafish endoglin locus and demonstrated that it produces two phylogenetically conserved protein isoforms using a distinctive alternative splicing mechanism. This preliminary work served as a base to the establishment of a Crispr/Cas9 engineered Endoglin mutant line from which functional analysis revealed that Endoglin deficiency results in massive fish death during the course from juvenile stage to adulthood. Endoglin deficient fish develop a cardiomegaly resulting in heart failure and hypochromic anemia which both stem from chronic hypoxia. A combination of histological analysis and confocal imaging evidenced structural alterations of the developing gill and its underlying vascular architecture that tally with respiratory distress and hypoxemia/hypoxia occurrence. Finally, phenylhydrazine treatment demonstrated that lowering hematocrit/blood viscosity constraint strongly alleviates heart failure and enhances survival of Endoglin deficient fish. Altogether our data support the notion that zebrafish Endoglin is crucial for gill proper development and respiratory function and that further studies using zebrafish in general and this endoglin mutant in particular will provide crucial hints of molecular and cellular events altered in HHT for the development of new therapeutic strategies.

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Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Kharrati-Koopaee

Ebrahimie

Dadpasand

et al. 2021

Journal of Genetic Engineering and Biotechnology

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Background Hypoxia refers to the condition of low oxygen pressure in the atmosphere and characterization of response to hypoxia as a biological complex puzzle, is challenging. Previously, we carried out a comparative genomic study by whole genome resequencing of highland and lowland Iranian native chickens to identify genomic variants associated with hypoxia conditions. Based on our previous findings, we used chicken as a model and the identified hypoxia-associated genes were converted to human’s orthologs genes to construct the informative gene network. The main goal of this study was to visualize the features of diseases due to hypoxia-associated genes by gene network analysis. Results It was found that hypoxia-associated genes contained several gene networks of disorders such as Parkinson, Alzheimer, cardiomyopathy, drug toxicity, and cancers. We found that biological pathways are involved in mitochondrion dysfunctions including peroxynitrous acid production denoted in brain injuries. Lewy body and neuromelanin were reported as key symptoms in Parkinson disease. Furthermore, calmodulin, and amyloid precursor protein were detected as leader proteins in Alzheimer’s diseases. Dexamethasone was reported as the candidate toxic drug under the hypoxia condition that implicates diabetes, osteoporosis, and neurotoxicity. Our results suggested DNA damages caused by the high doses of UV radiation in high-altitude conditions, were associated with breast cancer, ovarian cancer, and colorectal cancer. Conclusions Our results showed that hypoxia-associated genes were enriched in several gene networks of disorders including Parkinson, Alzheimer, cardiomyopathy, drug toxicity, and different types of cancers. Furthermore, we suggested, UV radiation and low oxygen conditions in high-altitude regions may be responsible for the variety of human diseases.

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Cardiovascular Adaptation to High-Altitude Hypoxia

Cited by 4 publications

References 72 publications

Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic Neonatal Lambs on Residual Strain and Microstructure of the Arteries

Endoglin deficiency elicits hypoxia-driven congestive heart failure in zebrafish

Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

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