Cardiovascular actions and therapeutic potential of tanshinone IIA

Gao, Si; Liu, Zhiping; Li, Hong; Little, Peter J.; Liu, Peiqing; Xu, Suowen

doi:10.1016/j.atherosclerosis.2011.06.041

Cited by 301 publications

(203 citation statements)

References 72 publications

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“…Tan, one of the most bioactive constituents isolated from Salvia miltiorrhiza Bunge, has long been clinically used in Asian countries for the prevention and treatment of CVDs (8)(9)(10). Accumulating evidence suggests that Tan prevents the development of atherosclerosis by inhibiting LDL oxidation ( 28 ), scavenger receptor expression ( 21 ), matrix metalloproteinase expression and activity ( 11 ), pro-infl ammatory cytokine expression ( 29 ), and smooth muscle cell proliferation ( 30 ) and migration ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…I), a lipophilic pharmacologically active compound derived from the Chinese herb Salvia miltiorrhiza Bunge (Danshen), exerts multiple cardioprotective effects ( 8 ). Tan has long been used clinically in Asian countries for the prevention and treatment of several CVDs, such as coronary heart disease, angina pectoris, and myocardial infarction (8)(9)(10).…”

Section: Oil Red O Stainingmentioning

confidence: 99%

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Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

Liu

Wang

Huang

et al. 2014

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

Section: Oil Red O Stainingmentioning

confidence: 99%

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

Liu

Wang

Huang

et al. 2014

Journal of Lipid Research

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“…Danshen and its various formula products in numerous pharmaceutical dosage forms are commercially available and are commonly administered to treat inflammatory and cardiovascular diseases in the clinics in China with negligible adverse effects (14)(15)(16)(17). STS has been clinically used in Asian countries for the prevention and treatment of coronary heart disease (18). Recent studies indicated that STS exerts protective effects on hypoxic pulmonary hypertension, including lowering pulmonary artery pressure and decreasing pulmonary artery thickness and right ventricular hypertrophy (19).…”

Section: Abstract: Sts; Trpc; Soce; Pulmonary Hypertensionmentioning

confidence: 99%

Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats

Wang

Qian

Wan

et al. 2013

Am J Respir Cell Mol Biol

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Danshen, the dried root of Salvia miltiorrhiza, is widely used in clinics in China for treating various diseases, including cardiovascular diseases. Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA isolated as the major active component from Danshen, was recently reported to be effective in attenuating the characteristic pulmonary vascular changes associated with chronically hypoxic pulmonary hypertension (CHPH); however, the underlying detailed mechanisms are poorly understood. In this study, we investigated the effects of STS on basal intracellular Ca 21 concentration ([Ca 21 ] i ) and store-operated Ca 21 entry (SOCE) in distal pulmonary arterial smooth muscle cells (PASMCs) exposed to prolonged hypoxia or isolated from CHPH rats. SOCE measured by Mn 21 quenching of Fura-2 fluorescence in PASMCs from rats exposed to chronic hypoxia (10% O 2 , 21 d) was increased by 59%, and basal [Ca 21 ] i was increased by 119%; this effect was inhibited by intraperitoneal injection of STS. These inhibitory effects of STS on hypoxic increases of SOCE and basal [Ca 21 ] i were associated with reduced expression of canonical transient receptor potential (TRPC)1 and TRPC6 in distal pulmonary arterial smooth muscle and decreases on right ventricular pressure, right ventricular hypertrophy, and peripheral pulmonary vessel thickening. In ex vivo cultured distal PASMCs from normoxic rats, STS (0-25 mM) dose-dependently inhibited hypoxiainduced cell proliferation and migration, paralleled with attenuation in increases of basal [Ca 21 ] i , SOCE, mRNA, and protein expression of TRPC1 and TRPC6. STS also relieved right ventricular systolic pressure, right ventricular hypertrophy, and TRPC1 and TRPC6 protein expression in distal pulmonary arteries in a monocrotaline-induced rat model of pulmonary arterial hypertension. These results indicate that STS prevents pulmonary arterial hypertension development likely by inhibiting TRPC1 and TRPC6 expression, resulting in normalized basal [Ca 21 ] i and attenuated proliferation and migration of PASMCs.Keywords: STS; TRPC; SOCE; pulmonary hypertension Pulmonary arterial hypertension (PAH) is a rare yet life-threatening disease that affects 15 per 1 million adults, according to the most recent estimation in 2008 (1). It is physiologically defined by mean pulmonary arterial pressure of 25 mm Hg or greater at rest and is pathologically characterized by pulmonary vascular remodeling, including smooth muscle hypertrophy and intima thickening. Although significant progress has been made in the past decades in our understanding of PAH and in disease management, the prognosis is still poor, with a 1-year survival rate of 91.0% (2) and 3-year survival rate of 77% or less according to recent investigations (3-5). The principal treatments for PAH rely on approaches targeting the prostacyclin, endothelin, or NO pathways (phosphodiesterase inhibition) or, increasingly, on a combination of them (6-11). Few patients show indication for treatment with calcium channel...

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“…TSA has been shown to possess anti-infl ammatory and anti-oxidative properties, and proposed as a potential therapeutic agent in heart disease, liver disease, and cancer treatment (7,8). However, the neuroprotective mechanism of TSA on lead-induced defi cits has never been investigated.…”

Section: Introductionmentioning

confidence: 99%

Tanshinone IIA ameliorates lead (Pb)-induced cognitive deficits and oxidative stress in a rat pup model

Lm¹,

Lx²,

Wang³

et al. 2017

BLL

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OBJECTIVE: Chronic lead (Pb) exposure affects the developing central nervous system, whereas Tanshinone IIA (TSA) improves cognitive defi cits. METHODS: In this study, we investigated the effects of TSA against lead-induced neurotoxicity in a rat pup model. A total of thirty two healthy male Wistar rats were randomly divided into four groups: lead-treated group, lead plus TSA-treated 1 group, lead plus TSA-treated 2 group, and controls. After a 4-week lead exposure, memory function was determined using Morris water maze and the concentration of lead was measured in blood. Total superoxide dismutase (T-SOD), glutathione (GSH), malonaldehyde (MDA) and brain-derived neurotrophic factor (BDNF) activities were determined in hippocampus samples. RESULTS: Lead exposure causes decrease of body weight; increase of the blood lead concentration; decrease of antioxidant activities and BDNF content. However, co-administration of TSA with lead ameliorated the weight loss. Furthermore, TSA inhibited neurotoxicity as evidenced by decreased latency period and increase in percentage of time spent in the target quadrant. Administration of TSA also improved antioxidant activities by increased T-SOD, GSH, and decreased MDA activities compared to lead-treated group. CONCLUSION: This study provides evidence of that TSA has a neuroprotective effect against lead-induced cognitive defi cit by enhancing antioxidant activities in the brain (Tab. 2, Fig. 3, Ref. 27). Text in PDF www.elis.sk.

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Cardiovascular actions and therapeutic potential of tanshinone IIA

Cited by 301 publications

References 72 publications

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats

Tanshinone IIA ameliorates lead (Pb)-induced cognitive deficits and oxidative stress in a rat pup model

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