Cardiorespiratory Effects of the Intravenous Administration of Tiletamine‐Zolazepam to Dogs

Abstract

The anesthetic, hemodynamic, and respiratory effects of an intravenously administered 1:1 combination of tiletamine and zolazepam were evaluated in dogs. Each dog received tiletamine-zolazepam (6.6, 13.2, 19.8 mg/kg) on two occasions, once when awake and a second time with residual isoflurane anesthesia while instrumented for the recording of hemodynamic data. Tiletamine-zolazepam administered to conscious dogs resulted in good, rapid induction of anesthesia. Time to sternal recumbency (recovery) was dose-dependent. Character of recovery tended to be better with the lower dose. Tiletamine-zolazepam caused significant increases in heart rate after all doses and significant increases in cardiac output after the two larger doses. All doses caused significant decreases in arterial blood pressure at 1 minute. Arterial blood pressures returned to baseline and then increased significantly above baseline values. The rate of development of left ventricular pressure was significantly decreased 1 minute after the two higher doses, returned to normal, and then was significantly increased above baseline for all doses. Peripheral vascular resistance increased transiently 1 minute after the 6.6 mg/kg dose. Peripheral vascular resistance decreased significantly after the 13.2 and 19.8 mg/kg doses. Minute ventilation was significantly decreased only after the 19.8 mg/kg dose.

O butorfanol na anestesia pela romifidina-tiletamina-zolazepam em gatos

“…A associação de agonistas adrenérgicos alfa-2 à tiletamina-zolazepam resulta em importante decréscimo de freqüência cardíaca (WILSON et al, 1993;DEEM et al, 1998), fato observado somente após 90 minutos de anestesia no grupo RTZ, o que indica predomínio da ação cardioestimulatória da tiletamina em grande parte do tempo de anestesia (HELLYER et al, 1989 ;WILSON et al, 1993). A utilização de butorfanol associado à tiletamina-zolazepam promove Tabela 3 -Médias e desvios-padrão dos valores de freqüência cardíaca (FC), pressão arterial sistólica (PAS), diastólica (PAD), média (PAM), freqüência respiratória (FR), saturação parcial de oxihemoglobina (SpO2) e temperatura retal (TR) em gatos anestesiados com romifidina-tiletamina-zolazepam (RTZ) ou romifidina-tiletamina-zolazepam-butorfanol (RTZB).…”

“…Os efeitos sobre a função cardiovascular são mínimos, ocorrendo depressão inicial seguida pelo aumento da freqüência cardíaca, pressão arterial e resistência vascular, provavelmente resultado da ação inotrópica negativa da tiletamina e posterior aumento indireto do tono simpático (HELLYER et al, 1988;HELLYER et al, 1989;WILSON et al, 1993). Após a administração da associação, observa-se transitório decréscimo da freqüência respiratória e aumento da PaCO 2 , (HELLYER et al, 1988).…”

Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bears

“…are known to be affected by anesthetics (19,36). Even though the use of unanesthetized bears is challenging, it is clear that the echocardiography of conscious, well-adjusted subjects more accurately represents true cardiac physiology.…”

The Effects of Different Anesthetic Agents on Short Electroretinography Protocol in Dogs

“…It is a mix of 2 drugs, tiletamine and zolazepam, similar to the combination of ketamine and diazepam. In recent years, tiletamine-zolazepam has been the preferred choice for use in conducting clinical examinations and short duration surgeries due to its rapid induction and short recovery time [6]. To the best of the authors' knowledge no previous studies have been conducted to investigate whether tiletamine-zolazepam affects the result of ERG examination in veterinary medicine.…”