Cardiorenal syndrome: Multi‐organ dysfunction involving the heart, kidney and vasculature

Savira, Feby; Magaye, Ruth; Liew, Danny; Reid, Christopher M.; Kelly, Darren J.; Kompa, A.; Sangaralingham, S. Jeson; Burnett, John C.; Kaye, David M.; Wang, Bing Hui

doi:10.1111/bph.15065

Cited by 54 publications

(54 citation statements)

References 153 publications

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“…Pooled frequencies of acute cardiac injury, acute hepatic injury, and acute kidney injury Given the cardio-hepatic and cardio-renal interactions, we also analyzed the pooled frequency of acute liver injury and acute kidney injury in our selected studies [48][49][50][51][52].…”

Section: Elevated Levels Of Cardiac and Inflammatory Biomarkers Levelmentioning

confidence: 99%

Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool

et al. 2020

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Background: Coronavirus disease 2019 (COVID-19) pandemic has drastically affected global health. Despite several studies, there is yet a dearth of data regarding the mechanisms of cardiac injury, clinical presentation, risk factors, and treatment of COVID-19-associated cardiovascular disease. This systematic review and meta-analysis is aimed at defining the clinical, electrocardiographic, and pathologic spectrum of cardiovascular disease (CVD), frequency of elevated cardiac and inflammatory biomarkers, and their frequency and relationship with severity of the disease and mortality in COVID-19 patients and to develop a triage risk stratification tool (TRST) that can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. We conducted an online search in databases of PubMed and Embase to identify relevant studies. Data selection was in concordance with PRISMA guidelines. Results were presented as pooled frequencies, odds ratio, standardized mean difference (SMD), and forest and funnel plots. Results: We gathered a total of 54 studies and included 35 of them in our meta-analysis. Acute cardiac injury occurred in more than 25% of cases, mortality was 20 times higher, and admission to intensive care unit increased by 13.5 times. Hypertension was the most common pre-existing comorbidity with a frequency of 29.2%, followed by diabetes mellitus (13.5%). The deceased group of patients had higher cardiac and inflammatory biomarkers, with statistically significant SMD, compared with survivors. Pediatric patients were predominantly mildly affected. However, less frequently, the presentation was very similar to Kawasaki disease or Kawasaki shock syndrome. This latter presentation hass been called as multisystem inflammatory syndrome in children (MIS-C). Conclusions: There is a wide spectrum of cardiac involvement in COVID-19 patients, and hence a Triage Risk Stratification Tool can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy.

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Section: Elevated Levels Of Cardiac and Inflammatory Biomarkers Levelmentioning

confidence: 99%

Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool

et al. 2020

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“…Derangements in these interactions can initiate multiorgan dysfunction. In particular, heart and kidney functions are closely interrelated through a variety of dynamic and bidirectional mechanisms [ 128 , 129 ]; a pathological alteration in one organ can unfavorably affect function in another distant organ.…”

Section: Cardiorenal Syndrome and Ho-1mentioning

confidence: 99%

OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

et al. 2020

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In this review, we will evaluate how high-density lipoprotein (HDL) and the reverse cholesterol transport (RCT) pathway are critical for proper cardiovascular–renal physiology. We will begin by reviewing the basic concepts of HDL cholesterol synthesis and pathway regulation, followed by cardiorenal syndrome (CRS) pathophysiology. After explaining how the HDL and RCT pathways become dysfunctional through oxidative processes, we will elaborate on the potential role of HDL dysfunction in CRS. We will then present findings on how HDL function and the inducible antioxidant gene heme oxygenase-1 (HO-1) are interconnected and how induction of HO-1 is protective against HDL dysfunction and important for the proper functioning of the cardiovascular–renal system. This will substantiate the proposal of HO-1 as a novel therapeutic target to prevent HDL dysfunction and, consequently, cardiovascular disease, renal dysfunction, and the onset of CRS.

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“…A relação bidirecional e sinérgica entre o coração, os rins e os vasos sanguíneos, na qual falhas em um órgão pode provocar mudanças patológicas no outro é denominada, atualmente, síndrome cardiorrenal. Esta, ocorre na presença de disfunção vascular, causada por hipertensão, sobrecarga de volume e congestão venosa (Savira et al, 2020).…”

Section: Introductionunclassified

“…O Consenso da Iniciativa de Qualidade de Diálise Aguda formalizou uma definição para o termo síndrome cardiorrenal em 2010. Esse sistema de classificação divide a condição clínica em cinco tipos diferentes conforme a disfunção e cronicidade no órgão primário afetado (Savira et al, 2020).…”

Section: Introductionunclassified

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Fatores preditivos para o desenvolvimento da síndrome cardiorrenal em pacientes com insuficiência cardíaca

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2021

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Objetivo: analisar, a partir de uma revisão sistemática da literatura, quais são os fatores preditivos para o desenvolvimento da síndrome cardiorrenal em pacientes com insuficiência cardíaca. Métodos: efetuou-se uma revisão sistemática da literatura a partir da questão de pesquisa “Quais os fatores preditivos para o desenvolvimento da síndrome cardiorrenal em pacientes com insuficiência cardíaca?”. Para a seleção dos artigos que compõem este estudo, realizou-se uma busca nas seguintes bases de dados: Medical Publisher (PUBMED), Biblioteca Virtual em Saúde (BVS), Science Direct (SD) e Semantic Scholar utilizando-se como critérios de elegibilidade apenas estudos observacionais ou ensaios clínicos randomizados, que contemplassem a questão de pesquisa, que fossem relevantes e atuais para abordar o tema. A amostra final é composta por 25 publicações. Resultados: os principais fatores preditivos para o desenvolvimento da síndrome cardiorrenal se associam com os fatores de risco cardiovasculares e às manifestações geradas a partir do comprometimento renal. Conclusão: a junção de comorbidades do paciente, com fatores de risco para desenvolvimento de doença cardiovascular, de injúria renal aguda associado com marcadores laboratoriais de injúria miocárdica e de lesão renal podem atuar como fatores preditivos confiáveis para o desenvolvimento da síndrome cardiorrenal.

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Cardiorenal syndrome: Multi‐organ dysfunction involving the heart, kidney and vasculature

Cited by 54 publications

References 153 publications

Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool

Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool

OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

Fatores preditivos para o desenvolvimento da síndrome cardiorrenal em pacientes com insuficiência cardíaca

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