OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

Peterson, Stephen J.; Choudhary, Abu; Kalsi, Amardeep; Zhao, Shuyang; Alex, Ragin; Abraham, Nader G.

doi:10.3390/diagnostics10110976

Cited by 8 publications

(6 citation statements)

References 170 publications

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“…We propose that various post-translational modifications (for example, MPO adducts) might alter specific ox-HDL characteristics (for example, higher vs. lower affinity toward SR-BI); nonetheless, renal dysfunction can contribute toward "dysfunctional" HDL particles. Moreover, ox-HDL exhibits diminished endothelial nitric oxide synthase (eNOS) mediated endothelial protective function as well as anti-apoptotic activity, which leads to impaired endothelial repair and increased proinflammatory activation (84)(85)(86).…”

Section: Effects Of Chronic Inflammation On Hdlmentioning

confidence: 99%

HDL Composition, Heart Failure, and Its Comorbidities

Diab

Ripoll

Guo

et al. 2022

Front. Cardiovasc. Med.

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Although research on high-density lipoprotein (HDL) has historically focused on atherosclerotic coronary disease, there exists untapped potential of HDL biology for the treatment of heart failure. Anti-oxidant, anti-inflammatory, and endothelial protective properties of HDL could impact heart failure pathogenesis. HDL-associated proteins such as apolipoprotein A-I and M may have significant therapeutic effects on the myocardium, in part by modulating signal transduction pathways and sphingosine-1-phosphate biology. Furthermore, because heart failure is a complex syndrome characterized by multiple comorbidities, there are complex interactions between heart failure, its comorbidities, and lipoprotein homeostatic mechanisms. In this review, we will discuss the effects of heart failure and associated comorbidities on HDL, explore potential cardioprotective properties of HDL, and review novel HDL therapeutic targets in heart failure.

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Section: Effects Of Chronic Inflammation On Hdlmentioning

confidence: 99%

HDL Composition, Heart Failure, and Its Comorbidities

Diab

Ripoll

Guo

et al. 2022

Front. Cardiovasc. Med.

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“…The pathophysiological mechanism for cardiorenal syndrome has not been completely established, but in all its types, oxidative stress and inflammation appear to play an important role [ 93 ]. Given the high prevalence of CVD and CKD, the potential interest of several biomarkers for cardiorenal syndrome, pertinent for both conditions, has been investigated and a few renocardiovascular biomarkers have emerged.…”

Section: The Concept Of Hdl Dysfunctionality In Ckdmentioning

confidence: 99%

“…Given the high prevalence of CVD and CKD, the potential interest of several biomarkers for cardiorenal syndrome, pertinent for both conditions, has been investigated and a few renocardiovascular biomarkers have emerged. HDL alterations and dysfunction have been suggested to contribute to increase cardiorenal syndrome risk [ 93 ]. Oxidation of HDL (oxHDL) has been pointed to as a cause for dysfunctional HDL and as one potential renocardiovascular biomarker [ 93 ].…”

Section: The Concept Of Hdl Dysfunctionality In Ckdmentioning

confidence: 99%

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Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular Disease Risk in Chronic Kidney Disease?

et al. 2021

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Dyslipidemia is a major traditional risk factor for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients, although the altered lipid profile does not explain the number and severity of CVD events. High-density lipoprotein (HDL) is a heterogeneous (size, composition, and functionality) population of particles with different atherogenic or atheroprotective properties. HDL-cholesterol concentrations per se may not entirely reflect a beneficial or a risk profile for CVD. Large HDL in CKD patients may have a unique proteome and lipid composition, impairing their cholesterol efflux capacity. This lack of HDL functionality may contribute to the paradoxical coexistence of increased large HDL and enhanced risk for CVD events. Moreover, CKD is associated with inflammation, oxidative stress, diabetes, and/or hypertension that are able to interfere with the anti-inflammatory, antioxidative, and antithrombotic properties of HDL subpopulations. How these changes interfere with HDL functions in CKD is still poorly understood. Further studies are warranted to fully clarify if different HDL subpopulations present different functionalities and/or atheroprotective effects. To achieve this goal, the standardization of techniques would be valuable.

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“…White adipose tissue has higher NOV levels than beige and brown adipose tissue [15]. In addition, the inflammatory state is destructive to mitochondria and contributes to multiorgan dysfunction [30][31][32]. The ability to generate thermogenesis via mitochondrial electron transport chain (ETC) uncoupling is highest in brown fat, followed by beige, and finally least in white fat [19,20].…”

mentioning

confidence: 99%

The Association of Nephroblastoma Overexpressed (NOV) and Endothelial Progenitor Cells with Oxidative Stress in Obstructive Sleep Apnea

Fakhouri

Weingarten

Singh

et al. 2021

Oxidative Medicine and Cellular Longevity

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Objective. Obstructive sleep apnea (OSA) is a sleep disorder characterized by intermittent hypoxia, chronic inflammation, and oxidative stress and is associated with cardiometabolic disease. Several biological substrates have been associated with OSA such as nephroblastoma overexpressed (NOV), endothelial progenitor cells (EPC), and circulating endothelial cells (CEC). Few studies have looked at the association of NOV with OSA while the EPC/CEC relationships with OSA are unclear. In this study, we hypothesize that (1) NOV is associated with the severity of OSA independent of BMI, identifying a protein that may play a role in the biogenesis of OSA complications, and (2) EPCs and CECs are also associated with the severity of OSA and are biomarkers of endothelial dysfunction in OSA. Methods. 61 subjects underwent overnight polysomnography (PSG), clinical evaluation, and blood analysis for NOV, EPC, CEC, interleukin 6 (IL-6), and other potential biomarkers. Results. NOV and EPCs were independently associated with the oxygen desaturation index (ODI) after adjusting for potential confounders including body mass index (BMI), age, and sex (NOV p = 0.032 ; EPC p = 0.001 ). EPC was also independently associated with AHI after adjusting for BMI, age, and sex ( p = 0.017 ). IL-6 was independently associated with AHI, but not with ODI. Conclusion. NOV and EPC levels correlate with the degree of OSA independent of BMI, indicating that these biomarkers could potentially further elucidate the relationship between OSA patients and their risk of the subsequent development of cardiovascular disease.

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OX-HDL: A Starring Role in Cardiorenal Syndrome and the Effects of Heme Oxygenase-1 Intervention

Cited by 8 publications

References 170 publications

HDL Composition, Heart Failure, and Its Comorbidities

HDL Composition, Heart Failure, and Its Comorbidities

Subpopulations of High-Density Lipoprotein: Friends or Foes in Cardiovascular Disease Risk in Chronic Kidney Disease?

The Association of Nephroblastoma Overexpressed (NOV) and Endothelial Progenitor Cells with Oxidative Stress in Obstructive Sleep Apnea

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