Cardioprotective Potential of Ethanol Extract of Sonchus Arvensis L. Leaves on Isoproterenol-Induced Myocardial Infarction in Rat

Abstract

Sonchus arvensis L. leaves have been used traditionally to treat various disease conditions. This study is designed to evaluate cardioprotective potential of ethanol extract of S. arvensis leaves on isoproterenol-induced myocardial infarction in Wistar rat. Male Wistar albino rats were divided into three main groups: negative control (saline only), positive control (isoproterenol only), and S. arvensis extract treated groups. S. arvensis extract was administered in three doses; 50, 100, and 200 mg/kg b.w. p.o for 14 days. On day 13 and 14, isoproterenol (85 mg/kg bw) was given intraperitoneally to positive control and extract treated groups. The parameters studied were cardiac biomarker enzymes which were Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Lactate Dehydrogenase (LDH). The results showed that S. arvensis at dose of 50 mg/kg b.w. could significantly (P<0.05) reduce the level of CK, CK-MB, AST, ALT, and LDH in myocardial infarcted rats compared to positive control. The increase of the dose of S. arvensis extract was not followed by an increase of its cardioprotective activity. In conclusion, Sonchus arvensis L. leaves extract at dose of 50 mg/kg b.w. has potential to be developed as cardioprotective drug.

Water fraction of Sonchus arvensis (Linn.) leaves protects heart upon isoproterenol-induced myocardial infarction in rats and promotes survival of cardiomyocytes in vitro

“…In our previous study, pretreatment with ethanolic extract of S. arvensis (50, 100 and 200 mg/kg bw) daily for a period of 14 days attenuated significantly the serum activities of AST, ALT, CK, CK-MB and LDH enzymes compared to ISO alone treated (positive control) rats [12]. However, increase of the dose did not increase its activities.…”

In Vitro Inhibition Against Angiotensin Converting Enzyme by Sonchus arvensis Water Extract and Fractions as Antihypertension

“…As well as being a potential ACE inhibitor, [35] reported that tempuyung has cardioprotective properties that protect the heart considering hypertension is a cardiovascular disease. Tempuyung leaves are also known to have effectiveness as a diuretic, anti-inflammatory and antipyretic, and contain flavonoids in the form of luteolin [36], and contains kaempferol, orientin, and quercetin [27].…”