Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury

Cheng, Yangang; Tan, Jinyan; Li, Huifeng; Kong, Xiangpeng; Liu, Yan; Guo, Rui; Li, Guoyan; Yang, Bing‐You; Miao-rong, Pei

doi:10.1016/j.biopha.2017.12.052

Cited by 22 publications

(21 citation statements)

References 37 publications

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“…The NO signaling dependant effects were confirmed in presence of nonspecific nitric oxide synthase inhibitor, L-NAME with poor outcomes of combination (Khatua et al, 2012). A combination of aged garlic extract along with atenolol exhibited synergistic cardioprotective effects (Avula, Asdaq, & Asad, 2014) (Cheng et al, 2018). Thus, use of this TCM may be further explored clinically for alleviation of MI in patient population.…”

Section: Allium Sativum (Allicin)mentioning

confidence: 91%

“…The preparation exhibited reduction of inflammatory cytokines (IL‐6 and TNF‐α). The intervention exhibited reduction of apoptosis via downregulation of caspase‐3 and Bax, upregulation of Bcl‐2 and elevation of p‐Akt, p‐GSK‐3β, and p‐endothelial nitric oxide synthase (Cheng et al, ). Thus, use of this TCM may be further explored clinically for alleviation of MI in patient population.…”

Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 99%

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Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

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Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant-based interventions screened for cardioprotective effect in ISP-induced cardiotoxicity, and their probable mechanistic profile is summarized.

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Section: Allium Sativum (Allicin)mentioning

confidence: 91%

Section: Natural Products and Their Pharmacological Potential In Allementioning

confidence: 99%

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Allawadhi

Khurana

Sayed

et al. 2018

Phytotherapy Research

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“…A previous study has shown that total flavonoids (TF) reduce the risk of developing chronic diseases, such as cancer and cardiovascular diseases (10). Currently, few studies have investigated the biological activity of TF, particularly in human cancer cells (11)(12)(13). Wang et al (14) revealed that TF extracted from Cotinus coggygria exhibit potential therapeutic effect by reducing the proliferation and inducing apoptosis by regulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/ERK signaling pathway in glioblastoma cancer cells (14).…”

Section: Introductionmentioning

confidence: 99%

Total flavonoids suppress lung cancer growth via the COX‑2‑mediated Wnt/β‑catenin signaling pathway

Han

Fang

et al. 2020

Oncol Lett

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The aim of the present study was to explore the anti-cancer effects of total flavonoids (TF) on lung cancer and to investigate the underlying mechanism. The inhibitory effect of TF on the proliferation of A549 cells in vitro was measured using an MTT assay. The apoptotic rate of TF-treated A549 cells was analyzed using flow cytometry and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling. Migration and invasion assays were performed to investigate the anti-migration effect of TF on A549 cells. Reverse-transcription quantitative PCR was used to analyze BCL2-like 2, BCL2, Bax, Bad, cyclooxygenase 2 (COX-2), Wnt and β-catenin mRNA expression levels in A549 cells. The in vivo anti-cancer effect of TF was investigated in a subcutaneous xenograft model of lung cancer in BALB/c nude mice. The results obtained in the present study revealed that TF exerted a significant inhibitory effect on the proliferation of A549 cells in a dose-dependent manner (P<0.01). TF induced apoptosis of A549 cells, which exhibited increased and decreased expression of pro-and anti-apoptotic genes, respectively. Furthermore, TF had a significant inhibitory effect on the migration and invasion of A549 cells (P<0.01). The mRNA expression levels of COX-2, Wnt and β-catenin were significantly downregulated in TF-treated A549 cells compared with controls. Additionally, treatment with TF inhibited tumor growth in mice, with a tumor inhibition rate of 64.07% compared with the controls. TF exhibited significant tumor inhibitory effects in vivo by promoting the apoptosis of tumor cells. In conclusion, the results suggested that TF may regulate lung cancer growth via the COX-2-Wnt/β-catenin signaling pathway. TF may serve as a novel anti-cancer agent for the treatment of lung cancer.

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“…Flavonoids may facilitate an increase in mitochondrial Ca 2+ concentration by acting on the mitochondrial Ca 2+ uniporter (Montero et al, 2004 ). This may up-regulate the respiratory rate and ATP production and stimulate endothelial nitric oxide synthase (eNOS), increasing nitric oxide (NO) production (Duarte et al, 2014 ; Si et al, 2014 ; Cheng et al, 2018 ). The vasodilation induced by NO may enhance oxygen delivery to the active muscles also helping to improve performance (Calbet and Lundby, 2012 ; Si et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans

Gelabert‐Rebato

Wiebe²,

Martin‐Rincon

et al. 2018

Front. Physiol.

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It remains unknown whether polyphenols such as luteolin (Lut), mangiferin and quercetin (Q) have ergogenic effects during repeated all-out prolonged sprints. Here we tested the effect of Mangifera indica L. leaf extract (MLE) rich in mangiferin (Zynamite®) administered with either quercetin (Q) and tiger nut extract (TNE), or with luteolin (Lut) on sprint performance and recovery from ischemia-reperfusion. Thirty young volunteers were randomly assigned to three treatments 48 h before exercise. Treatment A: placebo (500 mg of maltodextrin/day); B: 140 mg of MLE (60% mangiferin) and 50 mg of Lut/day; and C: 140 mg of MLE, 600 mg of Q and 350 mg of TNE/day. After warm-up, subjects performed two 30 s Wingate tests and a 60 s all-out sprint interspaced by 4 min recovery periods. At the end of the 60 s sprint the circulation of both legs was instantaneously occluded for 20 s. Then, the circulation was re-opened and a 15 s sprint performed, followed by 10 s recovery with open circulation, and another 15 s final sprint. MLE supplements enhanced peak (Wpeak) and mean (Wmean) power output by 5.0–7.0% (P < 0.01). After ischemia, MLE+Q+TNE increased Wpeak by 19.4 and 10.2% compared with the placebo (P < 0.001) and MLE+Lut (P < 0.05), respectively. MLE+Q+TNE increased Wmean post-ischemia by 11.2 and 6.7% compared with the placebo (P < 0.001) and MLE+Lut (P = 0.012). Mean VO2 during the sprints was unchanged, suggesting increased efficiency or recruitment of the anaerobic capacity after MLE ingestion. In women, peak VO2 during the repeated sprints was 5.8% greater after the administration of MLE, coinciding with better brain oxygenation. MLE attenuated the metaboreflex hyperpneic response post-ischemia, may have improved O2 extraction by the Vastus Lateralis (MLE+Q+TNE vs. placebo, P = 0.056), and reduced pain during ischemia (P = 0.068). Blood lactate, acid-base balance, and plasma electrolytes responses were not altered by the supplements. In conclusion, a MLE extract rich in mangiferin combined with either quercetin and tiger nut extract or luteolin exerts a remarkable ergogenic effect, increasing muscle power in fatigued subjects and enhancing peak VO2 and brain oxygenation in women during prolonged sprinting. Importantly, the combination of MLE+Q+TNE improves skeletal muscle contractile function during ischemia/reperfusion.

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Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury

Cited by 22 publications

References 37 publications

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Isoproterenol‐induced cardiac ischemia and fibrosis: Plant‐based approaches for intervention

Total flavonoids suppress lung cancer growth via the COX‑2‑mediated Wnt/β‑catenin signaling pathway

Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans

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